CNPY4_HUMAN
ID CNPY4_HUMAN Reviewed; 248 AA.
AC Q8N129; Q8WUN9;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Protein canopy homolog 4;
DE Flags: Precursor;
GN Name=CNPY4; ORFNames=PSEC0237, UNQ1909/PRO4354;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION.
RX PubMed=16338228; DOI=10.1016/j.bbrc.2005.11.123;
RA Konno K., Wakabayashi Y., Akashi-Takamura S., Ishii T., Kobayashi M.,
RA Takahashi K., Kusumoto Y., Saitoh S., Yoshizawa Y., Miyake K.;
RT "A molecule that is associated with Toll-like receptor 4 and regulates its
RT cell surface expression.";
RL Biochem. Biophys. Res. Commun. 339:1076-1082(2006).
CC -!- FUNCTION: Plays a role in the regulation of the cell surface expression
CC of TLR4. {ECO:0000269|PubMed:16338228}.
CC -!- SUBUNIT: Interacts with TLR4. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8N129; Q9BRQ8: AIFM2; NbExp=3; IntAct=EBI-723824, EBI-3956936;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the canopy family. {ECO:0000305}.
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DR EMBL; AY359100; AAQ89458.1; -; mRNA.
DR EMBL; AK075537; BAC11680.1; -; mRNA.
DR EMBL; CH236956; EAL23850.1; -; Genomic_DNA.
DR EMBL; BC019903; AAH19903.2; -; mRNA.
DR EMBL; BC032339; AAH32339.1; -; mRNA.
DR CCDS; CCDS34701.1; -.
DR RefSeq; NP_689968.1; NM_152755.1.
DR AlphaFoldDB; Q8N129; -.
DR BioGRID; 128831; 19.
DR IntAct; Q8N129; 9.
DR STRING; 9606.ENSP00000262932; -.
DR iPTMnet; Q8N129; -.
DR PhosphoSitePlus; Q8N129; -.
DR BioMuta; CNPY4; -.
DR DMDM; 74728482; -.
DR EPD; Q8N129; -.
DR jPOST; Q8N129; -.
DR MassIVE; Q8N129; -.
DR MaxQB; Q8N129; -.
DR PaxDb; Q8N129; -.
DR PeptideAtlas; Q8N129; -.
DR PRIDE; Q8N129; -.
DR ProteomicsDB; 71530; -.
DR Antibodypedia; 2588; 53 antibodies from 18 providers.
DR DNASU; 245812; -.
DR Ensembl; ENST00000262932.5; ENSP00000262932.3; ENSG00000166997.8.
DR GeneID; 245812; -.
DR KEGG; hsa:245812; -.
DR MANE-Select; ENST00000262932.5; ENSP00000262932.3; NM_152755.2; NP_689968.1.
DR UCSC; uc003uto.4; human.
DR CTD; 245812; -.
DR DisGeNET; 245812; -.
DR GeneCards; CNPY4; -.
DR HGNC; HGNC:28631; CNPY4.
DR HPA; ENSG00000166997; Low tissue specificity.
DR MIM; 610047; gene.
DR neXtProt; NX_Q8N129; -.
DR OpenTargets; ENSG00000166997; -.
DR PharmGKB; PA162382618; -.
DR VEuPathDB; HostDB:ENSG00000166997; -.
DR eggNOG; KOG4052; Eukaryota.
DR GeneTree; ENSGT00390000014072; -.
DR HOGENOM; CLU_078068_0_1_1; -.
DR InParanoid; Q8N129; -.
DR OMA; TISDWYF; -.
DR OrthoDB; 1412562at2759; -.
DR PhylomeDB; Q8N129; -.
DR TreeFam; TF318951; -.
DR PathwayCommons; Q8N129; -.
DR SignaLink; Q8N129; -.
DR BioGRID-ORCS; 245812; 7 hits in 1075 CRISPR screens.
DR ChiTaRS; CNPY4; human.
DR GenomeRNAi; 245812; -.
DR Pharos; Q8N129; Tdark.
DR PRO; PR:Q8N129; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8N129; protein.
DR Bgee; ENSG00000166997; Expressed in stromal cell of endometrium and 180 other tissues.
DR ExpressionAtlas; Q8N129; baseline and differential.
DR Genevisible; Q8N129; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IMP:UniProtKB.
DR InterPro; IPR021852; DUF3456.
DR Pfam; PF11938; DUF3456; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..248
FT /note="Protein canopy homolog 4"
FT /id="PRO_0000314018"
FT REGION 200..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..230
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 38..196
FT /evidence="ECO:0000250"
FT DISULFID 41..184
FT /evidence="ECO:0000250"
FT DISULFID 94..156
FT /evidence="ECO:0000250"
FT VARIANT 168
FT /note="G -> R (in dbSNP:rs60551236)"
FT /id="VAR_062216"
SQ SEQUENCE 248 AA; 28310 MW; 561CAEB4A0D7B833 CRC64;
MGPVRLGILL FLFLAVHEAW AGMLKEEDDD TERLPSKCEV CKLLSTELQA ELSRTGRSRE
VLELGQVLDT GKRKRHVPYS VSETRLEEAL ENLCERILDY SVHAERKGSL RYAKGQSQTM
ATLKGLVQKG VKVDLGIPLE LWDEPSVEVT YLKKQCETML EEFEDIVGDW YFHHQEQPLQ
NFLCEGHVLP AAETACLQET WTGKEITDGE EKTEGEEEQE EEEEEEEEEG GDKMTKTGSH
PKLDREDL
