ID   CNR2_MAIZE              Reviewed;         181 AA.
AC   B6TYV8;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Cell number regulator 2;
DE   AltName: Full=ZmCNR02;
GN   Name=CNR2;
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, GENE FAMILY, AND
RP   NOMENCLATURE.
RC   STRAIN=cv. B73;
RX   PubMed=20400678; DOI=10.1105/tpc.109.073676;
RA   Guo M., Rupe M.A., Dieter J.A., Zou J., Spielbauer D., Duncan K.E.,
RA   Howard R.J., Hou Z., Simmons C.R.;
RT   "Cell Number Regulator1 affects plant and organ size in maize: implications
RT   for crop yield enhancement and heterosis.";
RL   Plant Cell 22:1057-1073(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=18937034; DOI=10.1007/s11103-008-9415-4;
RA   Alexandrov N.N., Brover V.V., Freidin S., Troukhan M.E., Tatarinova T.V.,
RA   Zhang H., Swaller T.J., Lu Y.-P., Bouck J., Flavell R.B., Feldmann K.A.;
RT   "Insights into corn genes derived from large-scale cDNA sequencing.";
RL   Plant Mol. Biol. 69:179-194(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. B73;
RA   Yu Y., Currie J., Lomeli R., Angelova A., Collura K., Wissotski M.,
RA   Campos D., Kudrna D., Golser W., Ashely E., Haller K., Descour A.,
RA   Fernandes J., Soderlund C., Walbot V.;
RT   "Maize full-length cDNA project.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a negative regulator of cell number.
CC       {ECO:0000269|PubMed:20400678}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in leaves, stalks and tassel spikelets.
CC       Detected in roots, apical meristems and immature ears, but not in
CC       pollen. In leaves, not detected in the cell division zone, expressed at
CC       low levels in the cell expansion and transition zones and at high
CC       levels in the mature or fully grown tissue.
CC       {ECO:0000269|PubMed:20400678}.
CC   -!- DEVELOPMENTAL STAGE: Highly expressed in ovules before fertilization,
CC       but turned off upon fertilization and not expressed in developing
CC       embryos or endosperm. Expression climbs again as the embryos mature.
CC   -!- SIMILARITY: Belongs to the cornifelin family. {ECO:0000305}.
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DR   EMBL; HM008654; ADI48416.1; -; mRNA.
DR   EMBL; EU970173; ACG42291.1; -; mRNA.
DR   EMBL; BT068908; ACN35805.1; -; mRNA.
DR   RefSeq; NP_001144684.1; NM_001151212.1.
DR   AlphaFoldDB; B6TYV8; -.
DR   STRING; 4577.GRMZM2G151230_P01; -.
DR   PaxDb; B6TYV8; -.
DR   PRIDE; B6TYV8; -.
DR   EnsemblPlants; Zm00001eb183220_T001; Zm00001eb183220_P001; Zm00001eb183220.
DR   GeneID; 100277715; -.
DR   Gramene; Zm00001eb183220_T001; Zm00001eb183220_P001; Zm00001eb183220.
DR   KEGG; zma:100277715; -.
DR   eggNOG; ENOG502S7UD; Eukaryota.
DR   HOGENOM; CLU_083147_1_2_1; -.
DR   OMA; CCQCCAL; -.
DR   OrthoDB; 1354725at2759; -.
DR   Proteomes; UP000007305; Chromosome 4.
DR   ExpressionAtlas; B6TYV8; baseline and differential.
DR   Genevisible; B6TYV8; ZM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:UniProtKB.
DR   InterPro; IPR006461; PLAC_motif_containing.
DR   PANTHER; PTHR15907; PTHR15907; 1.
DR   Pfam; PF04749; PLAC8; 1.
DR   TIGRFAMs; TIGR01571; A_thal_Cys_rich; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..181
FT                   /note="Cell number regulator 2"
FT                   /id="PRO_0000407730"
FT   TRANSMEM        88..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   181 AA;  19235 MW;  3402DC3BD421B4F1 CRC64;
     MYPKAADEGA QPLATGIPFS GGGGYYQAGG AMAAAFAVQA QAPVAAWSTG LCNCFDDCHN
     CCVTCVCPCI TFGQTAEIID RGSTSCGTSG ALYALVMLLT GCQCVYSCFY RAKMRAQYGL
     QVSPCSDCCV HCCCQCCALC QEYRELKKRG FDMSIGWHAN MERQGRAAAA VPPHMHPGMT
     R