ID   CNRB_DICDI              Reviewed;         619 AA.
AC   Q54RJ1;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=CLPTM1-like membrane protein cnrB;
GN   Name=cnrB; ORFNames=DDB_G0283115;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=16507593; DOI=10.1242/jcs.02819;
RA   Torija P., Vicente J.J., Rodrigues T.B., Robles A., Cerdan S., Sastre L.,
RA   Calvo R.M., Escalante R.;
RT   "Functional genomics in Dictyostelium: midA, a new conserved protein, is
RT   required for mitochondrial function and development.";
RL   J. Cell Sci. 119:1154-1164(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC       {ECO:0000269|PubMed:16507593}.
CC   -!- SIMILARITY: Belongs to the CLPTM1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000050; EAL65887.1; -; Genomic_DNA.
DR   RefSeq; XP_639245.1; XM_634153.1.
DR   AlphaFoldDB; Q54RJ1; -.
DR   STRING; 44689.DDB0229859; -.
DR   PaxDb; Q54RJ1; -.
DR   EnsemblProtists; EAL65887; EAL65887; DDB_G0283115.
DR   GeneID; 8623931; -.
DR   KEGG; ddi:DDB_G0283115; -.
DR   dictyBase; DDB_G0283115; cnrB.
DR   eggNOG; KOG2489; Eukaryota.
DR   HOGENOM; CLU_019907_3_1_1; -.
DR   InParanoid; Q54RJ1; -.
DR   OMA; NMLYGYL; -.
DR   PhylomeDB; Q54RJ1; -.
DR   PRO; PR:Q54RJ1; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   InterPro; IPR008429; CLPTM1.
DR   InterPro; IPR030434; CLPTM1L.
DR   PANTHER; PTHR21347; PTHR21347; 1.
DR   PANTHER; PTHR21347:SF0; PTHR21347:SF0; 1.
DR   Pfam; PF05602; CLPTM1; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..619
FT                   /note="CLPTM1-like membrane protein cnrB"
FT                   /id="PRO_0000331305"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        324..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        384..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        445..465
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        474..496
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          566..619
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        566..588
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   619 AA;  71928 MW;  4E1E72B5BA69AD69 CRC64;
     MNNQGGAVAA NGQRPQAQQQ QQQGGIMGII STLIRFMAIY YIASFAFSKF LGTGNNNNNG
     GVVLNNNNGT TNTSIPSNSV RLANSWPEGI EFNMKVYLST SNETVGDWLV WEQDKLSYDW
     KDSNTIPTKN ITFDTTPYLQ NNGSLFAHII TSRRAYLNQP KSQLHKVHPL IVYLPKPKPK
     GKNLLEEKSK DEPEVEYDPT ELISYWKPTL SLHLIVDHTI YPPDSIPKEI VSYFNITNGF
     YSPIIYCNEF WLYREHLKPV NETVKQLSIE INYSSMGLFK WQLQIQMQKS LDMQESFGGG
     GNSAMGGASV GDEFKRMLTD NDPWILGLTL IVSVLHTIFE FLAFKNDIQF WKNNKSMEGL
     SVKTITLNCV CMGIIFLYLL DNETSYMILA SSGFGFLVEF WKLGKAMTIK ITWMTSLPLP
     KRIEFINKDE YMSKTKQYDD MAMKYLSWLL FPLVIGTSIY SLYYHEHKSW YSWVVSSLVR
     TVYTFEFIMM TPQLFINYKL KSVSHLPWRV FMYRALNTFI DDLFAFIIKM PLLHRLSCLR
     DDIIFIVYLY QRWIYPVDKK RSHYGSEEAE EVQQQDKKEI KEKVEEREEE KQEEEEEEKE
     KEEESTSSSK VTKRKTKKV