ACL4_EMENI
ID ACL4_EMENI Reviewed; 383 AA.
AC C8V3W6; Q5B733;
DT 16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Probable assembly chaperone of rpl4 {ECO:0000305};
GN ORFNames=AN10433;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: Acts as a chaperone for the L4 ribosomal subunit, required
CC for hierarchical ribosome assembly. Shields ribosomal protein L4 until
CC timely release and insertion into the pre-ribosome is possible, once
CC ribosomal protein L18 is present. {ECO:0000250|UniProtKB:Q03771}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q03771}. Nucleus
CC {ECO:0000250|UniProtKB:Q03771}. Note=Distributed throughout the cell
CC but is enriched in the nucleus. {ECO:0000250|UniProtKB:Q03771}.
CC -!- SIMILARITY: Belongs to the ACL4 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAA59855.1; Type=Erroneous gene model prediction; Note=The predicted gene AN3647 has been split into 3 genes: AN10433, AN10449 and AN10450.; Evidence={ECO:0000305};
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DR EMBL; AACD01000061; EAA59855.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BN001302; CBF75703.1; -; Genomic_DNA.
DR AlphaFoldDB; C8V3W6; -.
DR SMR; C8V3W6; -.
DR STRING; 162425.CADANIAP00005091; -.
DR PRIDE; C8V3W6; -.
DR EnsemblFungi; CBF75703; CBF75703; ANIA_10433.
DR EnsemblFungi; EAA59855; EAA59855; AN3647.2.
DR VEuPathDB; FungiDB:AN10433; -.
DR eggNOG; ENOG502QSAH; Eukaryota.
DR HOGENOM; CLU_005651_0_0_1; -.
DR InParanoid; C8V3W6; -.
DR OMA; GGWCLYL; -.
DR OrthoDB; 1515022at2759; -.
DR Proteomes; UP000000560; Chromosome II.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IBA:GO_Central.
DR GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm; Nucleus; Reference proteome; Repeat;
KW Ribosome biogenesis; TPR repeat.
FT CHAIN 1..383
FT /note="Probable assembly chaperone of rpl4"
FT /id="PRO_0000417427"
FT REPEAT 35..68
FT /note="TPR 1"
FT REPEAT 73..106
FT /note="TPR 2"
FT REPEAT 116..147
FT /note="TPR 3"
FT REPEAT 193..226
FT /note="TPR 4"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..375
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 383 AA; 42859 MW; 25F0FB99DF394527 CRC64;
MGKPRPHKKK ASKTREKSVL SAGGSISKRK MNEDPRKLLE QATILLQTGQ ADAALSIAQQ
ALEIATSNSP AQLSSLNTIA EIYVELGEID LARKHFLQAV ELDPTGSIPE SEGGGAEKFL
WLAQLSELGG KDSVQWFEKG VGALRGIFRR SPLFFIAFSR ASYQADIFRW EEDAESRCEN
LITEALLVQP SSPEVLQTLA SIRISQLRED DARAALSRSL ELWKDLPPED PHVPDFPTRI
SLSRLLMEVS MLLEALEVLE RLILEDDQSV EAWYLGGWCL QLLAEIGEAP RDPEAESNET
PESKRHASLV ASREWLKQSL MLYDLVQYED ERLKEHALEL VEAMNKELGE EMEDDSNVED
GEGEGEEEWE GIESDSDHEM ADS
