ID   CNRG_CAVPO              Reviewed;          87 AA.
AC   Q9EQQ8;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma;
DE            Short=GMP-PDE gamma;
DE            EC=3.1.4.35;
GN   Name=PDE6G;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Airway smooth muscle;
RA   Tate R.J., Pyne N.J.;
RT   "Molecular cloning and characterization of an airway smooth muscle cyclic-
RT   GMP phosphodiesterase 6 gamma-subunit.";
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in processes of transmission and amplification
CC       of the visual signal. cGMP-PDEs are the effector molecules in G-
CC       protein-mediated phototransduction in vertebrate rods and cones (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746,
CC         ChEBI:CHEBI:58115; EC=3.1.4.35;
CC   -!- SUBUNIT: Oligomer composed of two catalytic chains (alpha and beta), an
CC       inhibitory chain (gamma) and the delta chain. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the rod/cone cGMP-PDE gamma subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AF132929; AAG43274.1; -; mRNA.
DR   RefSeq; NP_001166467.1; NM_001172996.1.
DR   RefSeq; XP_005001441.1; XM_005001384.2.
DR   AlphaFoldDB; Q9EQQ8; -.
DR   SMR; Q9EQQ8; -.
DR   STRING; 10141.ENSCPOP00000018118; -.
DR   Ensembl; ENSCPOT00000025817; ENSCPOP00000018118; ENSCPOG00000022389.
DR   GeneID; 100135595; -.
DR   KEGG; cpoc:100135595; -.
DR   CTD; 5148; -.
DR   eggNOG; ENOG502S20G; Eukaryota.
DR   GeneTree; ENSGT00390000013260; -.
DR   HOGENOM; CLU_170469_0_0_1; -.
DR   InParanoid; Q9EQQ8; -.
DR   OMA; KGRGWHP; -.
DR   OrthoDB; 1574918at2759; -.
DR   TreeFam; TF333297; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000022389; Expressed in pituitary gland.
DR   GO; GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030553; F:cGMP binding; IEA:InterPro.
DR   GO; GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0045745; P:positive regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.1120.10; -; 1.
DR   InterPro; IPR006952; PDE6_gamma.
DR   InterPro; IPR037030; PDE6_gamma_sf.
DR   PANTHER; PTHR12122; PTHR12122; 1.
DR   Pfam; PF04868; PDE6_gamma; 1.
DR   PIRSF; PIRSF000969; 35-cGMP_Pdiase_g; 1.
PE   3: Inferred from homology;
KW   Acetylation; cGMP; Hydrolase; Reference proteome; Sensory transduction;
KW   Vision.
FT   CHAIN           1..87
FT                   /note="Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic
FT                   phosphodiesterase subunit gamma"
FT                   /id="PRO_0000166115"
FT   REGION          16..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:P04972"
SQ   SEQUENCE   87 AA;  9653 MW;  21BF681796854C5D CRC64;
     MNLELPKAEI RSATRVVGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF GDDIPGMEGL
     GTDITVICPW EAFNHLELHE LAQYGII