CNRG_FELCA
ID CNRG_FELCA Reviewed; 87 AA.
AC P61248;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma;
DE Short=GMP-PDE gamma;
DE EC=3.1.4.35;
GN Name=PDE6G; Synonyms=PDEG;
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Gould D.J.;
RT "Molecular genetic investigations into the inherited progressive retinal
RT degenerations of dogs and cats.";
RL Thesis (1997), University of Cambridge, United Kingdom.
CC -!- FUNCTION: Participates in processes of transmission and amplification
CC of the visual signal. cGMP-PDEs are the effector molecules in G-
CC protein-mediated phototransduction in vertebrate rods and cones (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746,
CC ChEBI:CHEBI:58115; EC=3.1.4.35;
CC -!- SUBUNIT: Oligomer composed of two catalytic chains (alpha and beta), an
CC inhibitory chain (gamma) and the delta chain. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the rod/cone cGMP-PDE gamma subunit family.
CC {ECO:0000305}.
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DR EMBL; AJ417434; CAD10146.1; -; Genomic_DNA.
DR RefSeq; XP_019673941.1; XM_019818382.1.
DR AlphaFoldDB; P61248; -.
DR BMRB; P61248; -.
DR SMR; P61248; -.
DR STRING; 9685.ENSFCAP00000011984; -.
DR Ensembl; ENSFCAT00000012926; ENSFCAP00000011984; ENSFCAG00000012923.
DR GeneID; 101088443; -.
DR KEGG; fca:101088443; -.
DR CTD; 5148; -.
DR VGNC; VGNC:68763; PDE6G.
DR eggNOG; ENOG502S20G; Eukaryota.
DR GeneTree; ENSGT00390000013260; -.
DR HOGENOM; CLU_170469_0_0_1; -.
DR InParanoid; P61248; -.
DR OMA; KGRGWHP; -.
DR OrthoDB; 1574918at2759; -.
DR TreeFam; TF333297; -.
DR Proteomes; UP000011712; Chromosome E1.
DR Bgee; ENSFCAG00000012923; Expressed in eyeball of camera-type eye and 8 other tissues.
DR GO; GO:0042622; C:photoreceptor outer segment membrane; IBA:GO_Central.
DR GO; GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:UniProtKB-EC.
DR GO; GO:0030553; F:cGMP binding; IEA:InterPro.
DR GO; GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0045745; P:positive regulation of G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR Gene3D; 4.10.1120.10; -; 1.
DR InterPro; IPR006952; PDE6_gamma.
DR InterPro; IPR037030; PDE6_gamma_sf.
DR PANTHER; PTHR12122; PTHR12122; 1.
DR Pfam; PF04868; PDE6_gamma; 1.
DR PIRSF; PIRSF000969; 35-cGMP_Pdiase_g; 1.
PE 3: Inferred from homology;
KW Acetylation; cGMP; Hydrolase; Reference proteome; Sensory transduction;
KW Vision.
FT CHAIN 1..87
FT /note="Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic
FT phosphodiesterase subunit gamma"
FT /id="PRO_0000166116"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:P04972"
SQ SEQUENCE 87 AA; 9651 MW; 8EA7C7A1D7D14B9E CRC64;
MNLEPPKAEI RSATRVIGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF GDDIPGMEGL
GTDITVICPW EAFNHLELHE LAQYGII
