CNRG_MOUSE
ID CNRG_MOUSE Reviewed; 87 AA.
AC P09174;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma;
DE Short=GMP-PDE gamma;
DE EC=3.1.4.35;
GN Name=Pde6g; Synonyms=Pdeg;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INVOLVEMENT IN BLINDNESS.
RC TISSUE=Retina;
RX PubMed=2835267; DOI=10.1016/0014-5793(88)80413-7;
RA Tuteja N., Farber D.B.;
RT "Gamma-subunit of mouse retinal cyclic-GMP phosphodiesterase: cDNA and
RT corresponding amino acid sequence.";
RL FEBS Lett. 232:182-186(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Participates in processes of transmission and amplification
CC of the visual signal. cGMP-PDEs are the effector molecules in G-
CC protein-mediated phototransduction in vertebrate rods and cones.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746,
CC ChEBI:CHEBI:58115; EC=3.1.4.35;
CC -!- SUBUNIT: Oligomer composed of two catalytic chains (alpha and beta), an
CC inhibitory chain (gamma) and the delta chain.
CC -!- DISEASE: Note=Deficiency in GMP-PDE activity cause accumulation of cGMP
CC in visual cells. The elevated cGMP levels are associated with
CC degeneration of the photoreceptors and blindness.
CC {ECO:0000303|PubMed:2835267}.
CC -!- SIMILARITY: Belongs to the rod/cone cGMP-PDE gamma subunit family.
CC {ECO:0000305}.
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DR EMBL; Y00746; CAA68714.1; -; mRNA.
DR EMBL; BC082288; AAH82288.1; -; mRNA.
DR CCDS; CCDS36389.1; -.
DR PIR; S00612; ESMSGM.
DR RefSeq; NP_036197.1; NM_012065.3.
DR RefSeq; XP_006532518.1; XM_006532455.3.
DR AlphaFoldDB; P09174; -.
DR BioGRID; 202085; 1.
DR STRING; 10090.ENSMUSP00000026452; -.
DR iPTMnet; P09174; -.
DR PhosphoSitePlus; P09174; -.
DR PaxDb; P09174; -.
DR PRIDE; P09174; -.
DR ProteomicsDB; 283467; -.
DR Antibodypedia; 57116; 130 antibodies from 19 providers.
DR DNASU; 18588; -.
DR Ensembl; ENSMUST00000026452; ENSMUSP00000026452; ENSMUSG00000025386.
DR GeneID; 18588; -.
DR KEGG; mmu:18588; -.
DR UCSC; uc007mss.2; mouse.
DR CTD; 5148; -.
DR MGI; MGI:97526; Pde6g.
DR VEuPathDB; HostDB:ENSMUSG00000025386; -.
DR eggNOG; ENOG502S20G; Eukaryota.
DR GeneTree; ENSGT00390000013260; -.
DR HOGENOM; CLU_170469_0_0_1; -.
DR InParanoid; P09174; -.
DR OMA; KGRGWHP; -.
DR OrthoDB; 1574918at2759; -.
DR PhylomeDB; P09174; -.
DR TreeFam; TF333297; -.
DR Reactome; R-MMU-2485179; Activation of the phototransduction cascade.
DR Reactome; R-MMU-2514859; Inactivation, recovery and regulation of the phototransduction cascade.
DR Reactome; R-MMU-4086398; Ca2+ pathway.
DR BioGRID-ORCS; 18588; 3 hits in 70 CRISPR screens.
DR PRO; PR:P09174; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P09174; protein.
DR Bgee; ENSMUSG00000025386; Expressed in retinal neural layer and 51 other tissues.
DR ExpressionAtlas; P09174; baseline and differential.
DR Genevisible; P09174; MM.
DR GO; GO:0042622; C:photoreceptor outer segment membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:UniProtKB-EC.
DR GO; GO:0030553; F:cGMP binding; IEA:InterPro.
DR GO; GO:0030507; F:spectrin binding; ISO:MGI.
DR GO; GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; IDA:MGI.
DR GO; GO:0045745; P:positive regulation of G protein-coupled receptor signaling pathway; IDA:MGI.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IDA:MGI.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR Gene3D; 4.10.1120.10; -; 1.
DR InterPro; IPR006952; PDE6_gamma.
DR InterPro; IPR037030; PDE6_gamma_sf.
DR PANTHER; PTHR12122; PTHR12122; 1.
DR Pfam; PF04868; PDE6_gamma; 1.
DR PIRSF; PIRSF000969; 35-cGMP_Pdiase_g; 1.
PE 3: Inferred from homology;
KW Acetylation; cGMP; Hydrolase; Reference proteome; Sensory transduction;
KW Vision.
FT CHAIN 1..87
FT /note="Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic
FT phosphodiesterase subunit gamma"
FT /id="PRO_0000166118"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:P04972"
SQ SEQUENCE 87 AA; 9637 MW; 415CE37E2CF14B99 CRC64;
MNLEPPKGEI RSATRVIGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF GDDIPGMEGL
GTDITVICPW EAFNHLELHE LAQYGII
