CNRP1_HUMAN
ID CNRP1_HUMAN Reviewed; 164 AA.
AC Q96F85; B2R4D0; Q49AN4; Q9UFZ0;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=CB1 cannabinoid receptor-interacting protein 1;
DE Short=CRIP-1;
GN Name=CNRIP1; Synonyms=C2orf32;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH CNR1,
RP AND ALTERNATIVE SPLICING.
RC TISSUE=Brain;
RX PubMed=17895407; DOI=10.1124/mol.107.039263;
RA Niehaus J.L., Liu Y., Wallis K.T., Egertova M., Bhartur S.G.,
RA Mukhopadhyay S., Shi S., He H., Selley D.E., Howlett A.C., Elphick M.R.,
RA Lewis D.L.;
RT "CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor
RT interacting protein CRIP 1a.";
RL Mol. Pharmacol. 72:1557-1566(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-164 (ISOFORM 1).
RC TISSUE=Kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [7]
RP PROTEIN SEQUENCE OF 16-26; 52-74; 83-98 AND 154-160, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Brain, Cajal-Retzius cell, and Fetal brain cortex;
RA Lubec G., Afjehi-Sadat L., Chen W.-Q., Sun Y.;
RL Submitted (DEC-2008) to UniProtKB.
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: [Isoform 1]: Suppresses cannabinoid receptor CNR1-mediated
CC tonic inhibition of voltage-gated calcium channels.
CC {ECO:0000269|PubMed:17895407}.
CC -!- FUNCTION: [Isoform 2]: Does not suppress cannabinoid receptor CNR1-
CC mediated tonic inhibition of voltage-gated calcium channels.
CC {ECO:0000269|PubMed:17895407}.
CC -!- SUBUNIT: Interacts with the cannabinoid receptor CNR1 (via C-terminus).
CC Does not interact with cannabinoid receptor CNR2.
CC {ECO:0000269|PubMed:17895407}.
CC -!- INTERACTION:
CC Q96F85; Q9NRG1: PRTFDC1; NbExp=3; IntAct=EBI-958255, EBI-739759;
CC Q96F85; O95070: YIF1A; NbExp=3; IntAct=EBI-958255, EBI-2799703;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=CRIP1a;
CC IsoId=Q96F85-1; Sequence=Displayed;
CC Name=2; Synonyms=CRIP1b;
CC IsoId=Q96F85-2; Sequence=VSP_035598;
CC -!- SIMILARITY: Belongs to the CNRIP family. {ECO:0000305}.
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DR EMBL; AY144596; AAN41658.1; -; mRNA.
DR EMBL; AK311784; BAG34727.1; -; mRNA.
DR EMBL; AC015969; AAX93120.1; -; Genomic_DNA.
DR EMBL; CH471053; EAW99877.1; -; Genomic_DNA.
DR EMBL; BC011535; AAH11535.1; -; mRNA.
DR EMBL; AL110235; CAB53688.1; -; mRNA.
DR CCDS; CCDS1886.1; -. [Q96F85-1]
DR CCDS; CCDS46311.1; -. [Q96F85-2]
DR PIR; T14768; T14768.
DR RefSeq; NP_001104571.1; NM_001111101.1. [Q96F85-2]
DR RefSeq; NP_056278.1; NM_015463.2. [Q96F85-1]
DR RefSeq; XP_005264306.1; XM_005264249.1.
DR RefSeq; XP_006712047.1; XM_006711984.1.
DR AlphaFoldDB; Q96F85; -.
DR SMR; Q96F85; -.
DR BioGRID; 117427; 21.
DR IntAct; Q96F85; 10.
DR MINT; Q96F85; -.
DR STRING; 9606.ENSP00000263655; -.
DR iPTMnet; Q96F85; -.
DR PhosphoSitePlus; Q96F85; -.
DR BioMuta; CNRIP1; -.
DR UCD-2DPAGE; Q96F85; -.
DR EPD; Q96F85; -.
DR jPOST; Q96F85; -.
DR MassIVE; Q96F85; -.
DR MaxQB; Q96F85; -.
DR PaxDb; Q96F85; -.
DR PeptideAtlas; Q96F85; -.
DR PRIDE; Q96F85; -.
DR ProteomicsDB; 76501; -. [Q96F85-1]
DR ProteomicsDB; 76502; -. [Q96F85-2]
DR Antibodypedia; 30920; 92 antibodies from 24 providers.
DR DNASU; 25927; -.
DR Ensembl; ENST00000263655.4; ENSP00000263655.3; ENSG00000119865.9. [Q96F85-1]
DR Ensembl; ENST00000409559.7; ENSP00000386883.3; ENSG00000119865.9. [Q96F85-2]
DR GeneID; 25927; -.
DR KEGG; hsa:25927; -.
DR MANE-Select; ENST00000263655.4; ENSP00000263655.3; NM_015463.3; NP_056278.1.
DR UCSC; uc002sej.5; human. [Q96F85-1]
DR CTD; 25927; -.
DR DisGeNET; 25927; -.
DR GeneCards; CNRIP1; -.
DR HGNC; HGNC:24546; CNRIP1.
DR HPA; ENSG00000119865; Tissue enhanced (brain).
DR MIM; 618538; gene.
DR neXtProt; NX_Q96F85; -.
DR OpenTargets; ENSG00000119865; -.
DR PharmGKB; PA162382635; -.
DR VEuPathDB; HostDB:ENSG00000119865; -.
DR eggNOG; ENOG502QTXE; Eukaryota.
DR GeneTree; ENSGT00390000004284; -.
DR HOGENOM; CLU_110298_0_0_1; -.
DR InParanoid; Q96F85; -.
DR OMA; YCKMETS; -.
DR OrthoDB; 1364162at2759; -.
DR PhylomeDB; Q96F85; -.
DR TreeFam; TF332485; -.
DR PathwayCommons; Q96F85; -.
DR SignaLink; Q96F85; -.
DR BioGRID-ORCS; 25927; 11 hits in 1077 CRISPR screens.
DR GenomeRNAi; 25927; -.
DR Pharos; Q96F85; Tbio.
DR PRO; PR:Q96F85; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q96F85; protein.
DR Bgee; ENSG00000119865; Expressed in secondary oocyte and 179 other tissues.
DR ExpressionAtlas; Q96F85; baseline and differential.
DR Genevisible; Q96F85; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0008022; F:protein C-terminus binding; IDA:UniProtKB.
DR GO; GO:0031718; F:type 1 cannabinoid receptor binding; IPI:UniProtKB.
DR GO; GO:2000272; P:negative regulation of signaling receptor activity; IDA:UniProtKB.
DR GO; GO:0010469; P:regulation of signaling receptor activity; IDA:UniProtKB.
DR InterPro; IPR029204; CNRIP1.
DR PANTHER; PTHR31952; PTHR31952; 1.
DR Pfam; PF15043; CNRIP1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Direct protein sequencing; Reference proteome.
FT CHAIN 1..164
FT /note="CB1 cannabinoid receptor-interacting protein 1"
FT /id="PRO_0000089360"
FT VAR_SEQ 111..164
FT /note="FTDIGTFETVWQVKFYNYHKRDHCQWGSPFSVIEYECKPNETRSLMWVNKES
FT FL -> ECLEQRPQEISLTYECEE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17895407"
FT /id="VSP_035598"
FT CONFLICT 16
FT /note="I -> T (in Ref. 6; CAB53688)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 164 AA; 18648 MW; AB8432C13F44FF04 CRC64;
MGDLPGLVRL SIALRIQPND GPVFYKVDGQ RFGQNRTIKL LTGSSYKVEV KIKPSTLQVE
NISIGGVLVP LELKSKEPDG DRVVYTGTYD TEGVTPTKSG ERQPIQITMP FTDIGTFETV
WQVKFYNYHK RDHCQWGSPF SVIEYECKPN ETRSLMWVNK ESFL
