ACL4_SCHPO
ID ACL4_SCHPO Reviewed; 336 AA.
AC Q1MTN8;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Probable assembly chaperone of rpl4 {ECO:0000305};
GN ORFNames=SPBC16D10.01c {ECO:0000312|PomBase:SPBC16D10.01c};
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Acts as a chaperone for the L4 ribosomal subunit encoded by
CC rpl4A and rpl4B, required for hierarchical ribosome assembly. Shields
CC ribosomal protein L4 until timely release and insertion into the pre-
CC ribosome is possible, once ribosomal protein L18 is present.
CC {ECO:0000250|UniProtKB:Q03771}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q03771}. Nucleus
CC {ECO:0000250|UniProtKB:Q03771}. Nucleus, nucleolus
CC {ECO:0000269|PubMed:16823372}. Note=Distributed throughout the cell but
CC is enriched in the nucleus. {ECO:0000250|UniProtKB:Q03771}.
CC -!- SIMILARITY: Belongs to the ACL4 family. {ECO:0000305}.
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DR EMBL; CU329671; CAB51354.2; -; Genomic_DNA.
DR RefSeq; NP_596496.2; NM_001022416.3.
DR AlphaFoldDB; Q1MTN8; -.
DR SMR; Q1MTN8; -.
DR BioGRID; 276445; 8.
DR STRING; 4896.SPBC16D10.01c.1; -.
DR MaxQB; Q1MTN8; -.
DR PaxDb; Q1MTN8; -.
DR EnsemblFungi; SPBC16D10.01c.1; SPBC16D10.01c.1:pep; SPBC16D10.01c.
DR GeneID; 2539899; -.
DR KEGG; spo:SPBC16D10.01c; -.
DR PomBase; SPBC16D10.01c; -.
DR VEuPathDB; FungiDB:SPBC16D10.01c; -.
DR eggNOG; ENOG502QSAH; Eukaryota.
DR HOGENOM; CLU_040959_2_0_1; -.
DR InParanoid; Q1MTN8; -.
DR OMA; GGWCLYL; -.
DR PhylomeDB; Q1MTN8; -.
DR PRO; PR:Q1MTN8; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF13181; TPR_8; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm; Nucleus; Reference proteome; Repeat;
KW Ribosome biogenesis; TPR repeat.
FT CHAIN 1..336
FT /note="Probable assembly chaperone of rpl4"
FT /id="PRO_0000351428"
FT REPEAT 39..72
FT /note="TPR 1"
FT REPEAT 75..108
FT /note="TPR 2"
FT REPEAT 110..143
FT /note="TPR 3"
FT REPEAT 162..195
FT /note="TPR 4"
FT REGION 316..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 336 AA; 38108 MW; FF0068F6F7CBA172 CRC64;
MSVTDAELLE IREKLVKDET SEALILAKKA ADKSPKEDGR AFELLGEVYA ELADVKKARS
AFKEAVSRSK NLTNDQGYEK YLWLAQINDN GSKALKLYQK GVTILERLLI DKGEDADLKK
KIQGAYCSIA ELFMTDLCMQ PDAEENCELY TKLALQIDAT NAEALQTLAS MRISQQKIEE
AKDALSKCLQ SISRAATEDS VDLPTYAVRT SIVRLLIEVE MHEEAHQLLV YLQKEDDQIL
DIWYLLGWNC YVEAQNLQEQ GNGSEEEIKE LLMNAKFYFI SALGVYQKIG WDDEGIKSHI
QELLEILNGL GVPNMDEENE EAEWETSENE EEMDED
