CNRP1_MOUSE
ID CNRP1_MOUSE Reviewed; 164 AA.
AC Q5M8N0; Q3TAC7; Q3UFR2;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=CB1 cannabinoid receptor-interacting protein 1;
DE Short=CRIP-1;
GN Name=Cnrip1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=17895407; DOI=10.1124/mol.107.039263;
RA Niehaus J.L., Liu Y., Wallis K.T., Egertova M., Bhartur S.G.,
RA Mukhopadhyay S., Shi S., He H., Selley D.E., Howlett A.C., Elphick M.R.,
RA Lewis D.L.;
RT "CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor
RT interacting protein CRIP 1a.";
RL Mol. Pharmacol. 72:1557-1566(2007).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Suppresses cannabinoid receptor CNR1-mediated tonic
CC inhibition of voltage-gated calcium channels. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with the cannabinoid receptor CNR1 (via C-terminus).
CC Does not interact with cannabinoid receptor CNR2 (By similarity).
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in brain. Also detected in heart,
CC lung, intestine, kidney, testis, spleen, liver and muscle (at protein
CC level). {ECO:0000269|PubMed:17895407}.
CC -!- SIMILARITY: Belongs to the CNRIP family. {ECO:0000305}.
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DR EMBL; AK148349; BAE28498.1; -; mRNA.
DR EMBL; AK171947; BAE42741.1; -; mRNA.
DR EMBL; AL606466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466574; EDL40679.1; -; Genomic_DNA.
DR EMBL; CH466574; EDL40680.1; -; Genomic_DNA.
DR EMBL; BC087946; AAH87946.1; -; mRNA.
DR CCDS; CCDS24447.1; -.
DR RefSeq; NP_084137.1; NM_029861.2.
DR AlphaFoldDB; Q5M8N0; -.
DR SMR; Q5M8N0; -.
DR BioGRID; 237596; 4.
DR IntAct; Q5M8N0; 3.
DR MINT; Q5M8N0; -.
DR STRING; 10090.ENSMUSP00000050036; -.
DR iPTMnet; Q5M8N0; -.
DR PhosphoSitePlus; Q5M8N0; -.
DR SwissPalm; Q5M8N0; -.
DR MaxQB; Q5M8N0; -.
DR PaxDb; Q5M8N0; -.
DR PeptideAtlas; Q5M8N0; -.
DR PRIDE; Q5M8N0; -.
DR ProteomicsDB; 283583; -.
DR Antibodypedia; 30920; 92 antibodies from 24 providers.
DR DNASU; 380686; -.
DR Ensembl; ENSMUST00000058159; ENSMUSP00000050036; ENSMUSG00000044629.
DR GeneID; 380686; -.
DR KEGG; mmu:380686; -.
DR UCSC; uc007iby.1; mouse.
DR CTD; 25927; -.
DR MGI; MGI:1917505; Cnrip1.
DR VEuPathDB; HostDB:ENSMUSG00000044629; -.
DR eggNOG; ENOG502QTXE; Eukaryota.
DR GeneTree; ENSGT00390000004284; -.
DR HOGENOM; CLU_110298_0_0_1; -.
DR InParanoid; Q5M8N0; -.
DR OMA; YCKMETS; -.
DR OrthoDB; 1364162at2759; -.
DR PhylomeDB; Q5M8N0; -.
DR TreeFam; TF332485; -.
DR BioGRID-ORCS; 380686; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Cnrip1; mouse.
DR PRO; PR:Q5M8N0; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5M8N0; protein.
DR Bgee; ENSMUSG00000044629; Expressed in piriform cortex and 213 other tissues.
DR ExpressionAtlas; Q5M8N0; baseline and differential.
DR Genevisible; Q5M8N0; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0043209; C:myelin sheath; HDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0008022; F:protein C-terminus binding; ISO:MGI.
DR GO; GO:0031718; F:type 1 cannabinoid receptor binding; ISO:MGI.
DR GO; GO:2000272; P:negative regulation of signaling receptor activity; ISO:MGI.
DR GO; GO:0010469; P:regulation of signaling receptor activity; ISO:MGI.
DR InterPro; IPR029204; CNRIP1.
DR PANTHER; PTHR31952; PTHR31952; 1.
DR Pfam; PF15043; CNRIP1; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..164
FT /note="CB1 cannabinoid receptor-interacting protein 1"
FT /id="PRO_0000089362"
FT CONFLICT 149
FT /note="P -> H (in Ref. 1; BAE28498)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 164 AA; 18612 MW; 856D3B0E240ACD8D CRC64;
MGDLPGLVRL SIALRIQPND GPVFFKVDGQ RFGQNRTIKL LTGSSYKVEV KIKPTTLQVE
NISIGGVLVP LELKGKEPDG ERVVYTGIYD TEGVAPTKSG ERQPIQITMP FTDIGTFETV
WQVKFYNYHK RDHCQWGSPF SVIEYECKPN ETRSLMWVNK ESFL
