CNRP1_RAT
ID CNRP1_RAT Reviewed; 164 AA.
AC Q5M7A7; A2RQR5;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=CB1 cannabinoid receptor-interacting protein 1;
DE Short=CRIP-1;
GN Name=Cnrip1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH CNR1.
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=17895407; DOI=10.1124/mol.107.039263;
RA Niehaus J.L., Liu Y., Wallis K.T., Egertova M., Bhartur S.G.,
RA Mukhopadhyay S., Shi S., He H., Selley D.E., Howlett A.C., Elphick M.R.,
RA Lewis D.L.;
RT "CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor
RT interacting protein CRIP 1a.";
RL Mol. Pharmacol. 72:1557-1566(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 16-26; 52-74 AND 83-98, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=Sprague-Dawley; TISSUE=Brain, and Hippocampus;
RA Lubec G., Chen W.-Q., Kang S.U.;
RL Submitted (JUL-2007) to UniProtKB.
CC -!- FUNCTION: Suppresses cannabinoid receptor CNR1-mediated tonic
CC inhibition of voltage-gated calcium channels. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with the cannabinoid receptor CNR1 (via C-terminus).
CC Does not interact with cannabinoid receptor CNR2.
CC {ECO:0000269|PubMed:17895407}.
CC -!- SIMILARITY: Belongs to the CNRIP family. {ECO:0000305}.
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DR EMBL; AY883936; AAX68416.1; -; mRNA.
DR EMBL; BC088754; AAH88754.1; -; mRNA.
DR RefSeq; NP_001014254.1; NM_001014232.1.
DR PDB; 6WSK; X-ray; 1.55 A; A=1-164.
DR PDBsum; 6WSK; -.
DR AlphaFoldDB; Q5M7A7; -.
DR SMR; Q5M7A7; -.
DR BioGRID; 264650; 2.
DR IntAct; Q5M7A7; 1.
DR MINT; Q5M7A7; -.
DR STRING; 10116.ENSRNOP00000007104; -.
DR iPTMnet; Q5M7A7; -.
DR PhosphoSitePlus; Q5M7A7; -.
DR SwissPalm; Q5M7A7; -.
DR PaxDb; Q5M7A7; -.
DR PRIDE; Q5M7A7; -.
DR Ensembl; ENSRNOT00000007104; ENSRNOP00000007104; ENSRNOG00000005326.
DR GeneID; 364208; -.
DR KEGG; rno:364208; -.
DR UCSC; RGD:1308373; rat.
DR CTD; 25927; -.
DR RGD; 1308373; Cnrip1.
DR eggNOG; ENOG502QTXE; Eukaryota.
DR GeneTree; ENSGT00390000004284; -.
DR HOGENOM; CLU_110298_0_0_1; -.
DR InParanoid; Q5M7A7; -.
DR OMA; YCKMETS; -.
DR OrthoDB; 1364162at2759; -.
DR PRO; PR:Q5M7A7; -.
DR Proteomes; UP000002494; Chromosome 14.
DR Bgee; ENSRNOG00000005326; Expressed in frontal cortex and 20 other tissues.
DR ExpressionAtlas; Q5M7A7; baseline and differential.
DR Genevisible; Q5M7A7; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0008022; F:protein C-terminus binding; IDA:UniProtKB.
DR GO; GO:0031718; F:type 1 cannabinoid receptor binding; IPI:UniProtKB.
DR GO; GO:2000272; P:negative regulation of signaling receptor activity; IBA:GO_Central.
DR InterPro; IPR029204; CNRIP1.
DR PANTHER; PTHR31952; PTHR31952; 1.
DR Pfam; PF15043; CNRIP1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Reference proteome.
FT CHAIN 1..164
FT /note="CB1 cannabinoid receptor-interacting protein 1"
FT /id="PRO_0000089363"
FT STRAND 8..16
FT /evidence="ECO:0007829|PDB:6WSK"
FT TURN 17..20
FT /evidence="ECO:0007829|PDB:6WSK"
FT STRAND 37..43
FT /evidence="ECO:0007829|PDB:6WSK"
FT STRAND 45..54
FT /evidence="ECO:0007829|PDB:6WSK"
FT STRAND 61..64
FT /evidence="ECO:0007829|PDB:6WSK"
FT STRAND 67..70
FT /evidence="ECO:0007829|PDB:6WSK"
FT STRAND 72..74
FT /evidence="ECO:0007829|PDB:6WSK"
FT STRAND 83..90
FT /evidence="ECO:0007829|PDB:6WSK"
FT STRAND 103..114
FT /evidence="ECO:0007829|PDB:6WSK"
FT STRAND 116..126
FT /evidence="ECO:0007829|PDB:6WSK"
FT HELIX 131..134
FT /evidence="ECO:0007829|PDB:6WSK"
FT STRAND 135..139
FT /evidence="ECO:0007829|PDB:6WSK"
FT STRAND 141..148
FT /evidence="ECO:0007829|PDB:6WSK"
FT STRAND 150..152
FT /evidence="ECO:0007829|PDB:6WSK"
FT STRAND 157..164
FT /evidence="ECO:0007829|PDB:6WSK"
SQ SEQUENCE 164 AA; 18658 MW; B3190F0D633CEEE9 CRC64;
MGDLPGIVRL SIALRIQPND GPVFFKVDGQ RFGQNRTIKL LTGSSYKVEV KIKPTTLQVE
NISIGGVLVP LELKCKEPDG ERVVYTGIYD TEGVAPTKSG ERQPIQITMP FTDIGTFETV
WQVKFYNYHK RDHCQWGSPF SVIEYECKPN ETRSLMWVNK ESFL
