ID   CNSL_PENEN              Reviewed;         482 AA.
AC   A0A0A2K5R6;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   04-FEB-2015, sequence version 1.
DT   03-AUG-2022, entry version 23.
DE   RecName: Full=MFS-type transporter cnsL {ECO:0000303|PubMed:25571861};
DE   AltName: Full=Communesin biosynthesis cluster protein L {ECO:0000303|PubMed:25571861};
GN   Name=cnsL {ECO:0000303|PubMed:25571861}; ORFNames=PEX2_055460;
OS   Penicillium expansum (Blue mold rot fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=27334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MD-8;
RX   PubMed=25338147; DOI=10.1094/MPMI-09-14-0261-FI;
RA   Ballester A.R., Marcet-Houben M., Levin E., Sela N., Selma-Lazaro C.,
RA   Carmona L., Wisniewski M., Droby S., Gonzalez-Candelas L., Gabaldon T.;
RT   "Genome, transcriptome, and functional analyses of Penicillium expansum
RT   provide new insights into secondary metabolism and pathogenicity.";
RL   Mol. Plant Microbe Interact. 28:232-248(2015).
RN   [2]
RP   IDENTIFICATION, AND FUNCTION.
RX   PubMed=25571861; DOI=10.1002/anie.201411297;
RA   Lin H.C., Chiou G., Chooi Y.H., McMahon T.C., Xu W., Garg N.K., Tang Y.;
RT   "Elucidation of the concise biosynthetic pathway of the communesin indole
RT   alkaloids.";
RL   Angew. Chem. Int. Ed. 54:3004-3007(2015).
CC   -!- FUNCTION: MFS-type transporter; part of the gene cluster that mediates
CC       the biosynthesis of communesins, a prominent class of indole alkaloids
CC       with great potential as pharmaceuticals (PubMed:25571861). With the MFS
CC       transporter cnsO, is most likely responsible for cummunesins secretion
CC       and thereby may contribute to intrinsic resistance (Probable).
CC       {ECO:0000269|PubMed:25571861, ECO:0000305|PubMed:25571861}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Allantoate
CC       permease family. {ECO:0000255}.
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DR   EMBL; JQFZ01000090; KGO59705.1; -; Genomic_DNA.
DR   RefSeq; XP_016600818.1; XM_016742820.1.
DR   AlphaFoldDB; A0A0A2K5R6; -.
DR   EnsemblFungi; KGO59705; KGO59705; PEX2_055460.
DR   GeneID; 27678239; -.
DR   HOGENOM; CLU_001265_0_5_1; -.
DR   OrthoDB; 619250at2759; -.
DR   Proteomes; UP000030143; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 3.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..482
FT                   /note="MFS-type transporter cnsL"
FT                   /id="PRO_0000446467"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        304..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        426..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        100
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   482 AA;  53180 MW;  EB6A3AA5F39951C1 CRC64;
     MAADQVTISD EPKGGGVTAD AAVKAIKAGR NKDVDIAAQI VSDYADQMDG DTWSVEEERK
     LIRRIDWRLI PTLFVCATLS GLDKTAISAA AVYNIKTDLN LTGAEYSWIG SAPFFGGLLF
     MGPLAYCLQR VPAVPFFAFN VLCWGILEMS VTMVVSMWYR PEEQPKRNSI ILNVVAPIIN
     GFVAWVVGYY KGPYERWKII FLLVGALTIV TSVVVYFVLP NNPLEAKFLT PREKYIVIQR
     KAADNTGIES KTFKMEQVWE AIFDIKTWLI WIAIAALQVP NGGLTTFNTL IISGLGFDSL
     QTSLLAMPPG AMSTLSGIGL SYLAATTRRY RTAIVTVSIL LPLFGAVLCY ALPRTNLAGQ
     LVGLYILYTY WAPYVTLVSV YQANVAGHTK KITLYAWFYI AWATGNIIGP QTFRADQAPE
     YTGGTVAMII CYVVAMFAIT AYGVVCHLSN KKRAEAIEAR TAADHDWLDM TDKENVGFKY
     TT