ID   CNSN_PENEN              Reviewed;         953 AA.
AC   A0A0A2JW93;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   04-FEB-2015, sequence version 1.
DT   03-AUG-2022, entry version 31.
DE   RecName: Full=Communesin biosynthesis cluster-specific transcription factor cnsN {ECO:0000303|PubMed:25571861};
DE   AltName: Full=Communesin biosynthesis cluster protein N {ECO:0000303|PubMed:25571861};
GN   Name=cnsN {ECO:0000303|PubMed:25571861}; ORFNames=PEX2_055480;
OS   Penicillium expansum (Blue mold rot fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=27334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MD-8;
RX   PubMed=25338147; DOI=10.1094/MPMI-09-14-0261-FI;
RA   Ballester A.R., Marcet-Houben M., Levin E., Sela N., Selma-Lazaro C.,
RA   Carmona L., Wisniewski M., Droby S., Gonzalez-Candelas L., Gabaldon T.;
RT   "Genome, transcriptome, and functional analyses of Penicillium expansum
RT   provide new insights into secondary metabolism and pathogenicity.";
RL   Mol. Plant Microbe Interact. 28:232-248(2015).
RN   [2]
RP   IDENTIFICATION, AND FUNCTION.
RX   PubMed=25571861; DOI=10.1002/anie.201411297;
RA   Lin H.C., Chiou G., Chooi Y.H., McMahon T.C., Xu W., Garg N.K., Tang Y.;
RT   "Elucidation of the concise biosynthetic pathway of the communesin indole
RT   alkaloids.";
RL   Angew. Chem. Int. Ed. 54:3004-3007(2015).
CC   -!- FUNCTION: Transcriptional regulator; part of the gene cluster that
CC       mediates the biosynthesis of communesins, a prominent class of indole
CC       alkaloids with great potential as pharmaceuticals.
CC       {ECO:0000269|PubMed:25571861}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; JQFZ01000090; KGO59707.1; -; Genomic_DNA.
DR   RefSeq; XP_016600820.1; XM_016742822.1.
DR   AlphaFoldDB; A0A0A2JW93; -.
DR   SMR; A0A0A2JW93; -.
DR   EnsemblFungi; KGO59707; KGO59707; PEX2_055480.
DR   GeneID; 27678241; -.
DR   HOGENOM; CLU_006632_3_0_1; -.
DR   OrthoDB; 356186at2759; -.
DR   Proteomes; UP000030143; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0016829; F:lyase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   Pfam; PF00701; DHDPS; 1.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   SMART; SM00906; Fungal_trans; 1.
PE   4: Predicted;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..953
FT                   /note="Communesin biosynthesis cluster-specific
FT                   transcription factor cnsN"
FT                   /id="PRO_0000446470"
FT   REGION          371..418
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   953 AA;  105072 MW;  241122EEFBB387C4 CRC64;
     MRPLPTGIYT PLPCFFHENE DIDIEALQSH VKFIASAGTI PVVSGSMGEA IHLNREEKKT
     IIRSARVALD EVNLHDVPIV AGAGGASTRE SIELCKDAAE AGADYVMVIP PGYYAGALLA
     DTSSIKKFFV DIAEASPLPV IIYNFPAVSG GIDMDSDLIV QIIQSSANIC GVKLTCANVG
     KLTRIMAQVS RPEFQAAFPR SSATPFRAID GFIDFLLPSI SVGSAGAISG LPNIAPKSCV
     KLWNLCQDSG SSKQATELQN LIALADGVAL KIGIAGMKKL LHRHFGRKVA CDMPNGPPCL
     RCTNKYQECT FEEGPGPRKR ARLCEQTETF GTCEQPDGWQ DLLTETRPNI GQSEDLEAVS
     PQGSLLGANQ ELESTSPRTS HSSLSQDDTA SLHSRSSLSS SPGRFPPSQK LVATSDSPSQ
     INSLEFIPDA FSFYIGPTGV TDIHILSHQK YNDQNVSLPK VNGLKYRIMD NPGQKEMATV
     DFSPPTVFGI TDHSLLEKAE PKLDPQLTEN GWPRLWAMMD PTAAWHLIKL YSRYIDPYFP
     ILSSHQIPSS SAELNKMPLA LLTAICATAL PFVMYDDSLY TMLLNPPSSE ELYRLCWLCI
     SQELHAPSLA TLQACLLLQQ RLPTNMYLSD TAFAWTLMAT SLAVAQTIGL HRDTGSWTSI
     PAWEKRLRRR LWWGLYAMEK WVALARGMPS HLGDDDYDVS MLKADDIQDT LSDSPDTQSH
     IYHLSNLSTI LSDIQRSFYS VKAIGKTSND LQYSLDLARP MRVRLKDWRD NLPSNLRPVS
     NAVISGEDLD GNGSLYLSYI VTHVALLRAL LRPLDRWPAI IKVNKEEPEA TYEGAKAVVT
     GALLCVKEFV EFVERLTGAQ WNAFWHSWSR PNFAIAGSFM VHLLQIVTPP NQTDSQSMPE
     LLKYSFEKEH TELQDWIRRW RWATRISANG AAGVKGLTNL GFIKVETLIG NGT