CNT6_SCHPO
ID CNT6_SCHPO Reviewed; 923 AA.
AC Q10165;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Probable ribosylation factor GTPase-activating protein cnt6;
GN Name=cnt6; ORFNames=SPAC26A3.10;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: GTPase-activating protein for the ADP ribosylation factor
CC family. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Cell tip
CC {ECO:0000269|PubMed:16823372}. Cell septum
CC {ECO:0000269|PubMed:16823372}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329670; CAA93233.1; -; Genomic_DNA.
DR PIR; T38398; T38398.
DR RefSeq; NP_594153.1; NM_001019577.2.
DR AlphaFoldDB; Q10165; -.
DR SMR; Q10165; -.
DR BioGRID; 278551; 2.
DR STRING; 4896.SPAC26A3.10.1; -.
DR iPTMnet; Q10165; -.
DR MaxQB; Q10165; -.
DR PaxDb; Q10165; -.
DR PRIDE; Q10165; -.
DR EnsemblFungi; SPAC26A3.10.1; SPAC26A3.10.1:pep; SPAC26A3.10.
DR GeneID; 2542074; -.
DR KEGG; spo:SPAC26A3.10; -.
DR PomBase; SPAC26A3.10; cnt6.
DR VEuPathDB; FungiDB:SPAC26A3.10; -.
DR eggNOG; KOG0521; Eukaryota.
DR HOGENOM; CLU_316209_0_0_1; -.
DR InParanoid; Q10165; -.
DR OMA; RQMIEAC; -.
DR PhylomeDB; Q10165; -.
DR PRO; PR:Q10165; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0030428; C:cell septum; IEA:UniProtKB-SubCell.
DR GO; GO:0051286; C:cell tip; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005096; F:GTPase activator activity; ISM:PomBase.
DR GO; GO:0008289; F:lipid binding; ISM:PomBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006886; P:intracellular protein transport; NAS:PomBase.
DR GO; GO:1905279; P:regulation of retrograde transport, endosome to Golgi; ISS:PomBase.
DR Gene3D; 1.10.220.150; -; 1.
DR Gene3D; 1.20.1270.60; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR045258; ACAP1/2/3-like.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23180; PTHR23180; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF103657; SSF103657; 1.
DR SUPFAM; SSF57863; SSF57863; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; GTPase activation; Metal-binding; Phosphoprotein;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..923
FT /note="Probable ribosylation factor GTPase-activating
FT protein cnt6"
FT /id="PRO_0000074230"
FT DOMAIN 526..632
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT DOMAIN 714..837
FT /note="Arf-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT ZN_FING 730..754
FT /note="C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT REGION 444..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 207
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 923 AA; 104497 MW; AB05E0F369E0AA3B CRC64;
MDGSDSLLKS VDVSKLDNGS TISFRAREDG FLESISSSSG KLVDMVLDST SKECLPKFSF
QNKLDFYFLF SDRVLQLQKE RKVLVLIHCE SLQSFDSFFA QKLKYADLIS SDNVHEIFLP
DSNAANIRYH WEWSPPSGKL LEYECKNYSC IAVYSTEDCT LERISKFSYY TVSRCGDSMD
DTFFSESQRV TSPLTTSQTV QTQPPQSPEA KTELSLINTK TVIFPENYED GPSFRSMLHE
LEQKSSLMKY YCKKIMKRIV QLSDAYDASQ VAVMKLSETL SEASNSTSMN MDILLDSYLT
KAMDIHATFI QKLNYDLINL LYEPFHNIYS SFIKPIDDRR LEFDEQSKSF YGSLSRYLSA
KKDKKGGDSK FFQKEKTFAL QRYDYYCFMQ DLHDGSIIND INGIFLQYFH RQYDHIALFS
NLMNSVLPNL QQLNLKLEKT KWSTTRRDKG REMHRSQVIQ TSGRPKSMAP PSPSPISPSF
PLHEIQSPMP NRRMAASADD ISQTSNFTTE IKGKCISNGG SASPDKIFKE GLLLVFGATE
LGTDLAMVSK AAWHKHWIVV ENGSLWEYAN WKDSVKSNVS SISLKHASAD KVRKQGRRFC
FEVVTPKLKR LYQATSAEEM DSWIEAICEA AKISSFQLSR VATPLSASVR RPSKVFPLFS
TSFETTPISR KLSGSGIKKA FSRKGSWNLQ QFFRSDNSGT MHMEQLERYH ASANIFIQML
RKTDVSNSVC ADCGSVKDVT WCSINIPVVL CIECSGIHRS LGTHISKTRS LLLDSLSQQS
KVLLCKIGNA AVNRVYEKGL SNPSLKPKPE HNAQVKLAFA QKKYVEHAFI DFAGVDADAT
LLEGLEQNKI SKILLGLAAK PNFEENGVVF LKAVTRDTSK LHLLELLFMN GLLLPDSEQL
SEHVSPDMQS YLSQKQFTKY LKE
