ACL6A_MACFA
ID ACL6A_MACFA Reviewed; 429 AA.
AC Q4R333;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Actin-like protein 6A;
DE AltName: Full=BRG1-associated factor 53A;
DE Short=BAF53A;
GN Name=ACTL6A; Synonyms=BAF53A; ORFNames=QtsA-19983;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in transcriptional activation and repression of
CC select genes by chromatin remodeling (alteration of DNA-nucleosome
CC topology). Component of SWI/SNF chromatin remodeling complexes that
CC carry out key enzymatic activities, changing chromatin structure by
CC altering DNA-histone contacts within a nucleosome in an ATP-dependent
CC manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A
CC and for association of the SMARCA4/BRG1/BAF190A containing remodeling
CC complex BAF with chromatin/nuclear matrix. Belongs to the neural
CC progenitors-specific chromatin remodeling complex (npBAF complex) and
CC is required for the proliferation of neural progenitors. During neural
CC development a switch from a stem/progenitor to a postmitotic chromatin
CC remodeling mechanism occurs as neurons exit the cell cycle and become
CC committed to their adult state. The transition from proliferating
CC neural stem/progenitor cells to postmitotic neurons requires a switch
CC in subunit composition of the npBAF and nBAF complexes. As neural
CC progenitors exit mitosis and differentiate into neurons, npBAF
CC complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged
CC for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C
CC subunits in neuron-specific complexes (nBAF). The npBAF complex is
CC essential for the self-renewal/proliferative capacity of the
CC multipotent neural stem cells. The nBAF complex along with CREST plays
CC a role regulating the activity of genes essential for dendrite growth
CC (By similarity). Component of the NuA4 histone acetyltransferase (HAT)
CC complex which is involved in transcriptional activation of select genes
CC principally by acetylation of nucleosomal histones H4 and H2A. This
CC modification may both alter nucleosome - DNA interactions and promote
CC interaction of the modified histones with other proteins which
CC positively regulate transcription. This complex may be required for the
CC activation of transcriptional programs associated with oncogene and
CC proto-oncogene mediated growth induction, tumor suppressor mediated
CC growth arrest and replicative senescence, apoptosis, and DNA repair.
CC NuA4 may also play a direct role in DNA repair when recruited to sites
CC of DNA damage. Putative core component of the chromatin remodeling
CC INO80 complex which is involved in transcriptional regulation, DNA
CC replication and probably DNA repair (By similarity).
CC {ECO:0000250|UniProtKB:O96019, ECO:0000250|UniProtKB:Q9Z2N8}.
CC -!- SUBUNIT: Component of numerous complexes with chromatin remodeling and
CC histone acetyltransferase activity. Component of the NuA4 histone
CC acetyltransferase complex which contains the catalytic subunit
CC KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1,
CC DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A,
CC MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6.
CC The NuA4 complex interacts with MYC and the adenovirus E1A protein.
CC Component of a NuA4-related complex which contains EP400, TRRAP/PAF400,
CC SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin,
CC ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Component of the multiprotein
CC chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B
CC (PBAF) and related complexes. The canonical complex contains a
CC catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B)
CC and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and
CC SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes
CC may also be present permitting several possible combinations
CC developmentally and tissue specific. Component of the BAF complex,
CC which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B,
CC SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B,
CC SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and
CC one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In
CC muscle cells, the BAF complex also contains DPF3. Component of the
CC BAF53 complex, at least composed of ACTL6A/BAF53A, RUVBL1/TIP49,
CC SMARCA2/BRM/BAF190B and TRRAP/PAF400, and which may also include a HAT
CC activity related to, but distinct from, that of KAT5. Component of
CC neural progenitors-specific chromatin remodeling complex (npBAF
CC complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B,
CC SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B,
CC SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57,
CC SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of
CC SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL
CC (mutually exclusive), BRD9, SS18, SMARCA2/BRM, SMARCA4/BRG1/BAF190A,
CC ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A. May be a component of
CC the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of
CC SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B,
CC SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C,
CC SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin.
CC Interacts with SMARCA4/BRG1/BAF190A (By similarity). Interacts with
CC PHF10/BAF45A (By similarity). Component of the chromatin remodeling
CC INO80 complex; specifically part of a complex module associated with
CC the DBINO domain of INO80 (By similarity). Interacts with DPF2 (By
CC similarity). {ECO:0000250|UniProtKB:O96019,
CC ECO:0000250|UniProtKB:Q9Z2N8}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O96019}.
CC -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR EMBL; AB179435; BAE02486.1; -; mRNA.
DR AlphaFoldDB; Q4R333; -.
DR SMR; Q4R333; -.
DR STRING; 9541.XP_005546497.1; -.
DR eggNOG; KOG0679; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0071564; C:npBAF complex; ISS:UniProtKB.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; ISS:UniProtKB.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0043968; P:histone H2A acetylation; ISS:UniProtKB.
DR GO; GO:0043967; P:histone H4 acetylation; ISS:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR004001; Actin_CS.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR Pfam; PF00022; Actin; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS00432; ACTINS_2; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Activator; Chromatin regulator; DNA damage; DNA recombination;
KW DNA repair; Growth regulation; Isopeptide bond; Neurogenesis; Nucleus;
KW Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:O96019"
FT CHAIN 2..429
FT /note="Actin-like protein 6A"
FT /id="PRO_0000260760"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:O96019"
FT MOD_RES 86
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O96019"
FT MOD_RES 233
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O96019"
FT CROSSLNK 62
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O96019"
SQ SEQUENCE 429 AA; 47417 MW; B2A0CBA78620B7A5 CRC64;
MSGGVYGGDE VGALVFDIGS YTVRAGYAGE DCPKVDFPTA IGMVVERDDG STLMEIDGDK
GKQGGPTYYI ATNALRVPRE NMEAISPLKN GMVEDWDSFQ AILDHTYKMH VKSEASLHPV
LMSEAPWNTR AKREKLTELM FEHYNIPAFF LCKTAVLTAF ANGRSTGLIL DSGATHTTAI
PVHDGYVLQQ GIVKSPLAGD FITMQCRELF QEMNIELVPP YMIASKEAVR EGSPANWKRK
EKLPQVTRSW HNYMCNCVIQ DFQASVLQVS DSTYDEQVAA QMPTVHYEFP NGYNCDFGAE
RLKIPEGLFD PSNVKGLSGN TMLGVSHVVT TSVGMCDIDI RPGLYGSVIV AGGNTLIQSF
TDRLNRELSQ KTPPSMRLKL IANNTTVERR FSSWIGGSIL ASLGTFQQMW ISKQEYEEGG
KQCVERKCP
