CNTD1_HUMAN
ID CNTD1_HUMAN Reviewed; 330 AA.
AC Q8N815; Q658Q6; Q8NEP1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Cyclin N-terminal domain-containing protein 1 {ECO:0000305};
GN Name=CNTD1 {ECO:0000312|HGNC:HGNC:26847}; Synonyms=CNTD;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Stomach;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays a role in the different steps of crossover formation
CC during meiotic recombination. Participates in the crossover
CC differentiation step of crossover-specific recombination intermediates
CC through its interaction with PRR19. In addition, stimulates crossover
CC formation through the interactions with RFC3 and RFC4 and
CC simultaneously regulates cell-cycle progression through interactions
CC with CDC34 and subsequent ubiquitination of WEE1. May also participates
CC in an active deselection process that destabilizes or removes excess
CC pre-CO intermediates. {ECO:0000250|UniProtKB:Q9D995}.
CC -!- SUBUNIT: Interacts with PRR19; this interaction promotes crossover
CC formation. Interacts with RFC3 and RFC4; these interactions facilitate
CC crossover formation. Interacts with CDC34; this interaction regulates
CC the cell-cycle progression. {ECO:0000250|UniProtKB:Q9D995}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9D995}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9D995}. Chromosome
CC {ECO:0000250|UniProtKB:Q9D995}. Note=Shuttles between the nucleus and
CC cytoplasm in a stage-specific manner of prophase I cells. Co-localized
CC at crossover sites with PRR19. {ECO:0000250|UniProtKB:Q9D995}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N815-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N815-2; Sequence=VSP_030111;
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DR EMBL; AK097456; BAC05060.1; -; mRNA.
DR EMBL; AL833052; CAH56287.1; -; mRNA.
DR EMBL; CH471152; EAW60886.1; -; Genomic_DNA.
DR EMBL; BC026187; AAH26187.1; -; mRNA.
DR CCDS; CCDS11440.1; -. [Q8N815-1]
DR RefSeq; NP_001317151.1; NM_001330222.1.
DR RefSeq; NP_775749.2; NM_173478.2. [Q8N815-1]
DR AlphaFoldDB; Q8N815; -.
DR BioGRID; 125891; 2.
DR STRING; 9606.ENSP00000465204; -.
DR iPTMnet; Q8N815; -.
DR PhosphoSitePlus; Q8N815; -.
DR BioMuta; CNTD1; -.
DR DMDM; 166216083; -.
DR PaxDb; Q8N815; -.
DR PeptideAtlas; Q8N815; -.
DR PRIDE; Q8N815; -.
DR ProteomicsDB; 72360; -. [Q8N815-1]
DR Antibodypedia; 17117; 96 antibodies from 20 providers.
DR DNASU; 124817; -.
DR Ensembl; ENST00000588408.6; ENSP00000465204.1; ENSG00000176563.10. [Q8N815-1]
DR GeneID; 124817; -.
DR KEGG; hsa:124817; -.
DR MANE-Select; ENST00000588408.6; ENSP00000465204.1; NM_173478.3; NP_775749.2.
DR UCSC; uc002ibm.5; human. [Q8N815-1]
DR CTD; 124817; -.
DR DisGeNET; 124817; -.
DR GeneCards; CNTD1; -.
DR HGNC; HGNC:26847; CNTD1.
DR HPA; ENSG00000176563; Tissue enriched (testis).
DR MIM; 618166; gene.
DR neXtProt; NX_Q8N815; -.
DR OpenTargets; ENSG00000176563; -.
DR PharmGKB; PA142672089; -.
DR VEuPathDB; HostDB:ENSG00000176563; -.
DR eggNOG; ENOG502QVK8; Eukaryota.
DR GeneTree; ENSGT00440000033966; -.
DR InParanoid; Q8N815; -.
DR OMA; VTEDYML; -.
DR OrthoDB; 1572593at2759; -.
DR PhylomeDB; Q8N815; -.
DR PathwayCommons; Q8N815; -.
DR SignaLink; Q8N815; -.
DR BioGRID-ORCS; 124817; 14 hits in 1068 CRISPR screens.
DR ChiTaRS; CNTD1; human.
DR GenomeRNAi; 124817; -.
DR Pharos; Q8N815; Tbio.
DR PRO; PR:Q8N815; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8N815; protein.
DR Bgee; ENSG00000176563; Expressed in left testis and 95 other tissues.
DR ExpressionAtlas; Q8N815; baseline and differential.
DR Genevisible; Q8N815; HS.
DR GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0035861; C:site of double-strand break; IBA:GO_Central.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IBA:GO_Central.
DR GO; GO:0051445; P:regulation of meiotic cell cycle; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR InterPro; IPR039890; CNTD1.
DR InterPro; IPR036915; Cyclin-like_sf.
DR PANTHER; PTHR21615; PTHR21615; 1.
DR SUPFAM; SSF47954; SSF47954; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Chromosome; Cytoplasm; Meiosis; Nucleus;
KW Reference proteome.
FT CHAIN 1..330
FT /note="Cyclin N-terminal domain-containing protein 1"
FT /id="PRO_0000313715"
FT DOMAIN 27..178
FT /note="Cyclin N-terminal"
FT VAR_SEQ 1..202
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_030111"
FT VARIANT 145
FT /note="T -> P (in dbSNP:rs12947820)"
FT /id="VAR_037708"
FT CONFLICT 4
FT /note="P -> S (in Ref. 1; BAC05060)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 330 AA; 36921 MW; 6A08ED50392706ED CRC64;
MDGPMRPRSA SLVDFQFGVV ATETIEDALL HLAQQNEQAV REASGRLGRF REPQIVEFVF
LLSEQWCLEK SVSYQAVEIL ERFMVKQAEN ICRQATIQPR DNKRESQNWR ALKQQLVNKF
TLRLVSCVQL ASKLSFRNKI ISNITVLNFL QALGYLHTKE ELLESELDVL KSLNFRINLP
TPLAYVETLL EVLGYNGCLV PAMRLHATCL TLLDLVYLLH EPIYESLLRA SIENSTPSQL
QGEKFTSVKE DFMLLAVGII AASAFIQNHE CWSQVVGHLQ SITGIALASI AEFSYAILTH
GVGANTPGRQ QSIPPHLAAR ALKTVASSNT
