ID   CNTE_STAAM              Reviewed;         397 AA.
AC   A0A0H3JTK0;
DT   05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   03-AUG-2022, entry version 31.
DE   RecName: Full=Staphylopine export protein {ECO:0000305};
GN   Name=cntE {ECO:0000303|PubMed:27230378};
GN   OrderedLocusNames=SAV2462 {ECO:0000312|EMBL:BAB58624.1};
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
RN   [2]
RP   FUNCTION, AND INDUCTION.
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=27230378; DOI=10.1126/science.aaf1018;
RA   Ghssein G., Brutesco C., Ouerdane L., Fojcik C., Izaute A., Wang S.,
RA   Hajjar C., Lobinski R., Lemaire D., Richaud P., Voulhoux R., Espaillat A.,
RA   Cava F., Pignol D., Borezee-Durant E., Arnoux P.;
RT   "Biosynthesis of a broad-spectrum nicotianamine-like metallophore in
RT   Staphylococcus aureus.";
RL   Science 352:1105-1109(2016).
CC   -!- FUNCTION: Involved in the export of the metallophore staphylopine.
CC       {ECO:0000269|PubMed:27230378}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Up-regulated in metal-poor media.
CC       {ECO:0000269|PubMed:27230378}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; BA000017; BAB58624.1; -; Genomic_DNA.
DR   RefSeq; WP_000675401.1; NC_002758.2.
DR   AlphaFoldDB; A0A0H3JTK0; -.
DR   SMR; A0A0H3JTK0; -.
DR   PaxDb; A0A0H3JTK0; -.
DR   EnsemblBacteria; BAB58624; BAB58624; SAV2462.
DR   KEGG; sav:SAV2462; -.
DR   HOGENOM; CLU_696200_0_0_9; -.
DR   OMA; LFVHQEL; -.
DR   PhylomeDB; A0A0H3JTK0; -.
DR   BioCyc; SAUR158878:SAV_RS13440-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..397
FT                   /note="Staphylopine export protein"
FT                   /id="PRO_0000447262"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        363..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   397 AA;  43295 MW;  D9307CE3A4347723 CRC64;
     MKGAMAWPFL RLYILTLMFF SANAILNVFI PLRGHDLGAT NTVIGIVMGA YMLTAMVFRP
     WAGQIIARVG PIKVLRIILI INAIALIIYG FTGLEGYFVA RVMQGVCTAF FSMSLQLGII
     DALPEEHRSE GVSLYSLFST IPNLIGPLVA VGIWNANNIS LFAIVIIFIA LTTTFFGYRV
     TFAEQEPDTS DKIEKMPFNA VTVFAQFFKN KELLNSGIIM IVASIVFGAV STFVPLYTVS
     LGFANAGIFL TIQAIAVVAA RFYLRKYIPS DGMWHPKYMV SVLSLLVIAS FVVAFGPQVG
     AIIFYGSAIL IGMTQAMVYP TLTSYLSFVL PKVGRNMLLG LFIACADLGI SLGGALMGPI
     SDLVGFKWMY LICGMLVIVI MIMSFLKKPT PRPASSL