CNTFR_CANLF
ID CNTFR_CANLF Reviewed; 372 AA.
AC Q71DR4;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Ciliary neurotrophic factor receptor subunit alpha;
DE Short=CNTF receptor subunit alpha;
DE Short=CNTFR-alpha;
DE Flags: Precursor;
GN Name=CNTFR;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12882818; DOI=10.1167/iovs.02-0763;
RA Beltran W.A., Zhang Q., Kijas J.W., Gu D., Rohrer H., Jordan J.A.,
RA Aguirre G.D.;
RT "Cloning, mapping, and retinal expression of the canine ciliary
RT neurotrophic factor receptor alpha (CNTFRalpha).";
RL Invest. Ophthalmol. Vis. Sci. 44:3642-3649(2003).
CC -!- FUNCTION: Binds to CNTF. The alpha subunit provides the receptor
CC specificity (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Forms a heterotrimer with LIFR and IL6ST. Interacts with
CC heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-
CC 1. Either alone or in complex with the heterodimer CLCF1-CRLF1
CC interacts with SORL1; this interaction may promote internalization and
CC lysosomal degradation. {ECO:0000250|UniProtKB:P26992}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC anchor {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in retina, brain, spleen, lung, liver and
CC kidney. In the retina it is highly expressed by photoreceptors, but
CC also found in the RPE, inner nuclear layer and ganglion cells.
CC {ECO:0000269|PubMed:12882818}.
CC -!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
CC folding and thereby efficient intracellular transport and cell-surface
CC receptor binding. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 3
CC subfamily. {ECO:0000305}.
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DR EMBL; AF529215; AAQ09101.1; -; mRNA.
DR RefSeq; NP_001003353.1; NM_001003353.1.
DR RefSeq; XP_005626431.1; XM_005626374.2.
DR RefSeq; XP_005626433.1; XM_005626376.2.
DR RefSeq; XP_005626434.1; XM_005626377.2.
DR RefSeq; XP_013973126.1; XM_014117651.1.
DR AlphaFoldDB; Q71DR4; -.
DR BMRB; Q71DR4; -.
DR SMR; Q71DR4; -.
DR STRING; 9612.ENSCAFP00000002838; -.
DR PaxDb; Q71DR4; -.
DR Ensembl; ENSCAFT00040016416; ENSCAFP00040014222; ENSCAFG00040008832.
DR Ensembl; ENSCAFT00845042894; ENSCAFP00845033622; ENSCAFG00845024273.
DR GeneID; 442941; -.
DR KEGG; cfa:442941; -.
DR CTD; 1271; -.
DR VEuPathDB; HostDB:ENSCAFG00845024273; -.
DR eggNOG; ENOG502QUDK; Eukaryota.
DR GeneTree; ENSGT00940000158864; -.
DR HOGENOM; CLU_047259_0_0_1; -.
DR InParanoid; Q71DR4; -.
DR OMA; KICDTGE; -.
DR OrthoDB; 741136at2759; -.
DR TreeFam; TF331210; -.
DR Reactome; R-CFA-6788467; IL-6-type cytokine receptor ligand interactions.
DR Proteomes; UP000002254; Chromosome 11.
DR Bgee; ENSCAFG00000001932; Expressed in thymus and 45 other tissues.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0070110; C:ciliary neurotrophic factor receptor complex; IBA:GO_Central.
DR GO; GO:0097059; C:CNTFR-CLCF1 complex; IBA:GO_Central.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR GO; GO:0070120; P:ciliary neurotrophic factor-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003530; Hematopoietin_rcpt_L_F3_CS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR Pfam; PF00041; fn3; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF49265; SSF49265; 2.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS01354; HEMATOPO_REC_L_F3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor;
KW Immunoglobulin domain; Lipoprotein; Membrane; Receptor; Reference proteome;
KW Repeat; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..342
FT /note="Ciliary neurotrophic factor receptor subunit alpha"
FT /id="PRO_0000010989"
FT PROPEP 343..372
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000010990"
FT DOMAIN 27..104
FT /note="Ig-like C2-type"
FT DOMAIN 108..205
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 206..306
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 301..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 290..294
FT /note="WSXWS motif"
FT COMPBIAS 312..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 342
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 60
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 70
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 142
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 46..89
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 372 AA; 40831 MW; 529405A00807BC0A CRC64;
MAAPVPWACC AVLAAAAAVV YAQRHSPQEA PHVQYERLGS DVTLPCGTAN WDAAVTWRVN
GTDLALDLLN GSQLVLHGLE LGHSGLYACF HRDSWHLRHQ VLLHVGLPPR EPVLSCRSNT
YPKGFYCSWH LPTPTYIPNT FNVTVLHGSK IMVCEKDPAL KNRCHIRYMH LFSTIKYKVS
ISVSNALGHN ATAITFDEFT IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL
KFFLRYRPLI LDQWQHVELS DGTTHTITDA YAGKEYIIQV AAKDYEIGTW SDWSVAAHAT
PWTEEPRHLT TEAQAPETTT STTSSLAPPP TTKICDPGEL GSGGGPSAPF LIHVPVTLAL
AAAAATANSL LI
