CNTFR_CHICK
ID CNTFR_CHICK Reviewed; 362 AA.
AC P51641;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Ciliary neurotrophic factor receptor subunit alpha;
DE Short=CNTF receptor subunit alpha;
DE Short=CNTFR-alpha;
DE AltName: Full=Growth-promoting activity receptor subunit alpha;
DE Short=GPA receptor subunit alpha;
DE Short=GPAR-alpha;
DE Flags: Precursor;
GN Name=CNTFR;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=7595532; DOI=10.1046/j.1471-4159.1995.65062393.x;
RA Ip F.C.F., Fu A.K.Y., Tsim K.W.K., Ip N.Y.;
RT "Cloning of the alpha component of the chick ciliary neurotrophic factor
RT receptor: developmental expression and down-regulation in denervated
RT skeletal muscle.";
RL J. Neurochem. 65:2393-2400(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7671828; DOI=10.1242/dev.121.8.2681;
RA Heller S., Finn T.P., Huber J., Nishi R., Geissen M., Pueschel A.W.,
RA Rohrer H.;
RT "Analysis of function and expression of the chick GPA receptor (GPAR alpha)
RT suggests multiple roles in neuronal development.";
RL Development 121:2681-2693(1995).
CC -!- FUNCTION: Binds to CNTF (GPA). The alpha subunit provides the receptor
CC specificity.
CC -!- SUBUNIT: Heterotrimer of the alpha subunit, LIFR and IL6ST.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC anchor {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in nervous system. Also found in
CC skeletal muscle.
CC -!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
CC folding and thereby efficient intracellular transport and cell-surface
CC receptor binding.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 3
CC subfamily. {ECO:0000305}.
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DR EMBL; U29245; AAA87838.1; -; mRNA.
DR EMBL; Z48168; CAA88184.1; -; mRNA.
DR PIR; S60614; S60614.
DR RefSeq; NP_990359.1; NM_205028.1.
DR AlphaFoldDB; P51641; -.
DR SMR; P51641; -.
DR STRING; 9031.ENSGALP00000040651; -.
DR GeneID; 395885; -.
DR KEGG; gga:395885; -.
DR CTD; 1271; -.
DR VEuPathDB; HostDB:geneid_395885; -.
DR eggNOG; ENOG502QUDK; Eukaryota.
DR HOGENOM; CLU_047259_0_0_1; -.
DR InParanoid; P51641; -.
DR OrthoDB; 741136at2759; -.
DR PhylomeDB; P51641; -.
DR PRO; PR:P51641; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0070110; C:ciliary neurotrophic factor receptor complex; IBA:GO_Central.
DR GO; GO:0097059; C:CNTFR-CLCF1 complex; IBA:GO_Central.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR GO; GO:0070120; P:ciliary neurotrophic factor-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003530; Hematopoietin_rcpt_L_F3_CS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003598; Ig_sub2.
DR Pfam; PF00041; fn3; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF49265; SSF49265; 2.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS01354; HEMATOPO_REC_L_F3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor;
KW Immunoglobulin domain; Lipoprotein; Membrane; Receptor; Reference proteome;
KW Repeat; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..334
FT /note="Ciliary neurotrophic factor receptor subunit alpha"
FT /id="PRO_0000010997"
FT PROPEP 335..362
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000010998"
FT DOMAIN 23..103
FT /note="Ig-like C2-type"
FT DOMAIN 106..203
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 204..304
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT MOTIF 288..292
FT /note="WSXWS motif"
FT LIPID 334
FT /note="GPI-anchor amidated aspartate"
FT /evidence="ECO:0000255"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 140
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 44..87
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 337
FT /note="A -> V (in Ref. 2; CAA88184)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 362 AA; 40308 MW; 5A90217EB48419F7 CRC64;
MANPVPSACC VVLAAVVVVY AQRHSQQDSH IQYERVGADV TMKCGSMDWD AAVTWTANGT
DIDDSHLNGS YLILKNVDLT QSGQYSCYEG SSWHLKYQTY LRVGVPPKEP VLMCRSNNYP
KGFYCSWHLP SPTYIPNSFN ISVIHGTREM VCEKDIFPKN RCHIRYLQLF STVKYKVTLT
VTNALGKNST TLTFDEFAIV KPDPPESVVA KPVPNNPRRL EVSWQNPSSW PDPESFPLKF
FLRYRPLILD QWQHVELSDG TSHTITDAYA GKEYIIQVAA KDNDIGTWSD WSVAVHATPW
TEEPKHLTTE VQITETTSTS TSSFMPPPTT KICDKGAGVG SGAVAVCWTA GLVLAAYGVL
FI
