ID   CNTF_CHICK              Reviewed;         195 AA.
AC   Q02011;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Ciliary neurotrophic factor;
DE            Short=CNTF;
DE   AltName: Full=Growth-promoting activity;
DE            Short=GPA;
GN   Name=CNTF; Synonyms=CNF, GPA;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1610564; DOI=10.1016/0896-6273(92)90126-x;
RA   Leung D.W., Parent A.S., Cachianes G., Lee A.L., Nikolics K., Esch F.,
RA   Coulombe J.N., Blacher R.W., Eckenstein F.P., Nishi R.;
RT   "Cloning, expression during development, and evidence for release of a
RT   trophic factor for ciliary ganglion neurons.";
RL   Neuron 8:1045-1053(1992).
RN   [2]
RP   PROTEIN SEQUENCE OF 155-175.
RX   PubMed=2322465; DOI=10.1016/0896-6273(90)90120-5;
RA   Eckenstein F.P., Esch F., Holbert T., Blacher R.W., Nishi R.;
RT   "Purification and characterization of a trophic factor for embryonic
RT   peripheral neurons: comparison with fibroblast growth factors.";
RL   Neuron 4:623-631(1990).
CC   -!- FUNCTION: CNTF is a survival factor for various neuronal cell types.
CC       Seems to prevent the degeneration of motor axons after axotomy.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- TISSUE SPECIFICITY: Nervous system.
CC   -!- SIMILARITY: Belongs to the CNTF family. {ECO:0000305}.
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DR   EMBL; M80827; AAA48784.1; -; mRNA.
DR   PIR; JH0680; JH0680.
DR   RefSeq; NP_990823.1; NM_205492.1.
DR   RefSeq; XP_015142256.1; XM_015286770.1.
DR   AlphaFoldDB; Q02011; -.
DR   SMR; Q02011; -.
DR   STRING; 9031.ENSGALP00000042605; -.
DR   PaxDb; Q02011; -.
DR   Ensembl; ENSGALT00000043216; ENSGALP00000042605; ENSGALG00000026207.
DR   GeneID; 396488; -.
DR   KEGG; gga:396488; -.
DR   CTD; 1270; -.
DR   VEuPathDB; HostDB:geneid_396488; -.
DR   eggNOG; ENOG502S4XX; Eukaryota.
DR   GeneTree; ENSGT00420000029890; -.
DR   HOGENOM; CLU_118647_0_0_1; -.
DR   InParanoid; Q02011; -.
DR   OMA; MESYVKH; -.
DR   OrthoDB; 1466128at2759; -.
DR   PhylomeDB; Q02011; -.
DR   PRO; PR:Q02011; -.
DR   Proteomes; UP000000539; Chromosome 5.
DR   Bgee; ENSGALG00000026207; Expressed in liver and 8 other tissues.
DR   GO; GO:0030424; C:axon; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005127; F:ciliary neurotrophic factor receptor binding; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0005138; F:interleukin-6 receptor binding; IEA:Ensembl.
DR   GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR   GO; GO:0048143; P:astrocyte activation; IBA:GO_Central.
DR   GO; GO:0070120; P:ciliary neurotrophic factor-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0048644; P:muscle organ morphogenesis; IEA:Ensembl.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central.
DR   GO; GO:0046533; P:negative regulation of photoreceptor cell differentiation; IEA:Ensembl.
DR   GO; GO:0048666; P:neuron development; IEA:Ensembl.
DR   GO; GO:0048680; P:positive regulation of axon regeneration; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0046668; P:regulation of retinal cell programmed cell death; IEA:Ensembl.
DR   GO; GO:0060221; P:retinal rod cell differentiation; IEA:Ensembl.
DR   GO; GO:0007260; P:tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000151; Ciliary_neurotrophic_fac_CNTF.
DR   PANTHER; PTHR15196; PTHR15196; 1.
DR   Pfam; PF01110; CNTF; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Developmental protein; Differentiation;
KW   Direct protein sequencing; Growth factor; Neurogenesis; Reference proteome.
FT   CHAIN           1..195
FT                   /note="Ciliary neurotrophic factor"
FT                   /id="PRO_0000149524"
SQ   SEQUENCE   195 AA;  21330 MW;  FEA076949DB34AC5 CRC64;
     MAAADTPSAT LRHHDLCSRG IRLARKMRSD VTDLLDIYVE RQGLDASISV AAVDGVPTAA
     VERWAEQTGT QRLLDNLAAY RAFRTLLAQM LEEQRELLGD TDAELGPALA AMLLQVSAFV
     YHLEELLELE SRGAPAEEGS EPPAPPRLSL FEQKLRGLRV LRELAQWAVR SVRDLRQLSK
     HGPGSGAALG LPESQ