CNTF_MOUSE
ID CNTF_MOUSE Reviewed; 198 AA.
AC P51642;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Ciliary neurotrophic factor;
DE Short=CNTF;
GN Name=Cntf;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=7835706; DOI=10.1016/0378-1119(94)00717-7;
RA Saotome Y., Winter C.G., Hirsh D.;
RT "A widely expressed novel C2H2 zinc-finger protein with multiple consensus
RT phosphorylation sites is conserved in mouse and man.";
RL Gene 152:233-238(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: CNTF is a survival factor for various neuronal cell types.
CC Seems to prevent the degeneration of motor axons after axotomy.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- TISSUE SPECIFICITY: Nervous system.
CC -!- SIMILARITY: Belongs to the CNTF family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U05342; AAA81912.1; -; mRNA.
DR EMBL; BC027539; AAH27539.1; -; mRNA.
DR CCDS; CCDS29637.1; -.
DR PIR; I48723; I48723.
DR RefSeq; NP_740756.1; NM_170786.2.
DR AlphaFoldDB; P51642; -.
DR SMR; P51642; -.
DR BioGRID; 198795; 3.
DR STRING; 10090.ENSMUSP00000108555; -.
DR iPTMnet; P51642; -.
DR PhosphoSitePlus; P51642; -.
DR PaxDb; P51642; -.
DR PRIDE; P51642; -.
DR ProteomicsDB; 283584; -.
DR Antibodypedia; 34925; 657 antibodies from 41 providers.
DR DNASU; 12803; -.
DR Ensembl; ENSMUST00000112933; ENSMUSP00000108555; ENSMUSG00000079415.
DR GeneID; 12803; -.
DR KEGG; mmu:12803; -.
DR UCSC; uc008gun.1; mouse.
DR CTD; 1270; -.
DR MGI; MGI:88439; Cntf.
DR VEuPathDB; HostDB:ENSMUSG00000079415; -.
DR eggNOG; ENOG502S4XX; Eukaryota.
DR GeneTree; ENSGT00420000029890; -.
DR HOGENOM; CLU_118647_0_0_1; -.
DR InParanoid; P51642; -.
DR OMA; MESYVKH; -.
DR OrthoDB; 1466128at2759; -.
DR PhylomeDB; P51642; -.
DR TreeFam; TF336237; -.
DR Reactome; R-MMU-6788467; IL-6-type cytokine receptor ligand interactions.
DR BioGRID-ORCS; 12803; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Gm44505; mouse.
DR PRO; PR:P51642; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; P51642; protein.
DR Bgee; ENSMUSG00000079415; Expressed in lens of camera-type eye and 75 other tissues.
DR ExpressionAtlas; P51642; baseline and differential.
DR Genevisible; P51642; MM.
DR GO; GO:0030424; C:axon; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0043025; C:neuronal cell body; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0032838; C:plasma membrane bounded cell projection cytoplasm; ISO:MGI.
DR GO; GO:0005127; F:ciliary neurotrophic factor receptor binding; ISO:MGI.
DR GO; GO:0005125; F:cytokine activity; ISO:MGI.
DR GO; GO:0008083; F:growth factor activity; ISO:MGI.
DR GO; GO:0005138; F:interleukin-6 receptor binding; ISO:MGI.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR GO; GO:0048143; P:astrocyte activation; ISO:MGI.
DR GO; GO:0070120; P:ciliary neurotrophic factor-mediated signaling pathway; ISO:MGI.
DR GO; GO:0060081; P:membrane hyperpolarization; ISO:MGI.
DR GO; GO:0048644; P:muscle organ morphogenesis; IGI:MGI.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISO:MGI.
DR GO; GO:1901215; P:negative regulation of neuron death; ISO:MGI.
DR GO; GO:0046533; P:negative regulation of photoreceptor cell differentiation; IDA:MGI.
DR GO; GO:0007399; P:nervous system development; ISO:MGI.
DR GO; GO:0048666; P:neuron development; IGI:MGI.
DR GO; GO:0048691; P:positive regulation of axon extension involved in regeneration; ISO:MGI.
DR GO; GO:0048680; P:positive regulation of axon regeneration; ISO:MGI.
DR GO; GO:0030307; P:positive regulation of cell growth; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IGI:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR GO; GO:0046887; P:positive regulation of hormone secretion; ISO:MGI.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:MGI.
DR GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISO:MGI.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISO:MGI.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IDA:MGI.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; ISO:MGI.
DR GO; GO:0060075; P:regulation of resting membrane potential; ISO:MGI.
DR GO; GO:0046668; P:regulation of retinal cell programmed cell death; IDA:MGI.
DR GO; GO:0060221; P:retinal rod cell differentiation; IDA:MGI.
DR GO; GO:0007260; P:tyrosine phosphorylation of STAT protein; IDA:MGI.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000151; Ciliary_neurotrophic_fac_CNTF.
DR PANTHER; PTHR15196; PTHR15196; 1.
DR Pfam; PF01110; CNTF; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Developmental protein; Differentiation; Growth factor;
KW Neurogenesis; Reference proteome.
FT CHAIN 1..198
FT /note="Ciliary neurotrophic factor"
FT /id="PRO_0000149520"
SQ SEQUENCE 198 AA; 22587 MW; 4EB03E7455653667 CRC64;
MAFAEQSPLT LHRRDLCSRS IWLARKIRSD LTALMESYVK HQGLNKNISL DSVDGVPVAS
TDRWSEMTEA ERLQENLQAY RTFQGMLTKL LEDQRVHFTP TEGDFHQAIH TLTLQVSAFA
YQLEELMALL EQKVPEKEAD GMPVTIGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRVIS
SHHMGISAHE SHYGAKQM
