ID   CNTF_PIG                Reviewed;         200 AA.
AC   O02732;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Ciliary neurotrophic factor;
DE            Short=CNTF;
GN   Name=CNTF;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9363597; DOI=10.1111/j.1365-2052.1997.00159.x;
RA   Weaks R.L., Ramsoondar J.J., Gallagher D.S. Jr., Nogues C.,
RA   Piedrahita J.A.;
RT   "Isolation, characterization and chromosomal localization of the porcine
RT   ciliary neurotrophic factor (CNTF) gene.";
RL   Anim. Genet. 28:354-357(1997).
CC   -!- FUNCTION: CNTF is a survival factor for various neuronal cell types.
CC       Seems to prevent the degeneration of motor axons after axotomy (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- TISSUE SPECIFICITY: Nervous system.
CC   -!- SIMILARITY: Belongs to the CNTF family. {ECO:0000305}.
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DR   EMBL; U57644; AAC27342.1; -; Genomic_DNA.
DR   AlphaFoldDB; O02732; -.
DR   SMR; O02732; -.
DR   STRING; 9823.ENSSSCP00000021143; -.
DR   PaxDb; O02732; -.
DR   Ensembl; ENSSSCT00005012220; ENSSSCP00005007150; ENSSSCG00005007790.
DR   Ensembl; ENSSSCT00015012115; ENSSSCP00015004765; ENSSSCG00015009195.
DR   Ensembl; ENSSSCT00025038433; ENSSSCP00025016226; ENSSSCG00025028324.
DR   Ensembl; ENSSSCT00030038384; ENSSSCP00030017640; ENSSSCG00030027394.
DR   Ensembl; ENSSSCT00035042389; ENSSSCP00035016940; ENSSSCG00035031991.
DR   Ensembl; ENSSSCT00040004135; ENSSSCP00040001294; ENSSSCG00040003304.
DR   Ensembl; ENSSSCT00050038513; ENSSSCP00050015952; ENSSSCG00050028640.
DR   Ensembl; ENSSSCT00060068667; ENSSSCP00060029509; ENSSSCG00060050507.
DR   eggNOG; ENOG502S4XX; Eukaryota.
DR   InParanoid; O02732; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0030424; C:axon; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005127; F:ciliary neurotrophic factor receptor binding; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0048143; P:astrocyte activation; IBA:GO_Central.
DR   GO; GO:0070120; P:ciliary neurotrophic factor-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central.
DR   GO; GO:0048680; P:positive regulation of axon regeneration; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000151; Ciliary_neurotrophic_fac_CNTF.
DR   PANTHER; PTHR15196; PTHR15196; 1.
DR   Pfam; PF01110; CNTF; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Differentiation; Growth factor;
KW   Neurogenesis; Reference proteome.
FT   CHAIN           1..200
FT                   /note="Ciliary neurotrophic factor"
FT                   /id="PRO_0000149521"
SQ   SEQUENCE   200 AA;  22718 MW;  40507C4457ED6531 CRC64;
     MAFAEHSPLT PHRRDLCSRS IWLARKIRSD LTALMEAYVK HQGLNENINL DSVDGVPMAS
     TDRWSELTEA ERLQENLRAY RTFHVMLARL LEDQREHFTP AEDDFHQAIH TIVLQVAAFA
     YQLEELMVLL EHKVPPSEAD GTPLSVGGGG LFEKKLWGLK VLQELSQWTV RSIRDLRVIS
     SHQAGVPAHG SHHVAKDKKM