ID   CNTF_RABIT              Reviewed;         199 AA.
AC   P14188;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Ciliary neurotrophic factor;
DE            Short=CNTF;
GN   Name=CNTF;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX   PubMed=2587985; DOI=10.1126/science.2587985;
RA   Lin L.-F.H., Mismer D., Lile J.D., Armes L.G., Butler E.T. III,
RA   Vannice J.L., Collins F.;
RT   "Purification, cloning, and expression of ciliary neurotrophic factor
RT   (CNTF).";
RL   Science 246:1023-1025(1989).
RN   [2]
RP   PARTIAL PROTEIN SEQUENCE.
RX   PubMed=2341413; DOI=10.1016/s0021-9258(19)38979-3;
RA   Lin L.-F.H., Armes L.G., Sommer A., Smith D.J., Collins F.;
RT   "Isolation and characterization of ciliary neurotrophic factor from rabbit
RT   sciatic nerves.";
RL   J. Biol. Chem. 265:8942-8947(1990).
CC   -!- FUNCTION: CNTF is a survival factor for various neuronal cell types.
CC       Seems to prevent the degeneration of motor axons after axotomy.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- TISSUE SPECIFICITY: Nervous system.
CC   -!- SIMILARITY: Belongs to the CNTF family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M29828; AAA31202.1; -; mRNA.
DR   PIR; A40082; UNRBCF.
DR   RefSeq; NP_001075752.1; NM_001082283.1.
DR   AlphaFoldDB; P14188; -.
DR   SMR; P14188; -.
DR   STRING; 9986.ENSOCUP00000004675; -.
DR   GeneID; 100009117; -.
DR   KEGG; ocu:100009117; -.
DR   CTD; 1270; -.
DR   eggNOG; ENOG502S4XX; Eukaryota.
DR   InParanoid; P14188; -.
DR   OrthoDB; 1466128at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005127; F:ciliary neurotrophic factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0070120; P:ciliary neurotrophic factor-mediated signaling pathway; IEA:InterPro.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:InterPro.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000151; Ciliary_neurotrophic_fac_CNTF.
DR   PANTHER; PTHR15196; PTHR15196; 1.
DR   Pfam; PF01110; CNTF; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Developmental protein; Differentiation;
KW   Direct protein sequencing; Growth factor; Neurogenesis; Reference proteome.
FT   CHAIN           1..199
FT                   /note="Ciliary neurotrophic factor"
FT                   /id="PRO_0000149522"
SQ   SEQUENCE   199 AA;  22662 MW;  C9C6F39A26DCAAE2 CRC64;
     MAFMEHSALT PHRRELCSRT IWLARKIRSD LTALTESYVK HQGLNKNINL DSVDGVPMAS
     TDQWSELTEA ERLQENLQAY RTFHIMLARL LEDQQVHFTP AEGDFHQAIH TLLLQVAAFA
     YQIEELMVLL ECNIPPKDAD GTPVIGGDGL FEKKLWGLKV LQELSHWTVR SIHDLRVISC
     HQTGIPAHGS HYIANDKEM