CNTF_RAT
ID CNTF_RAT Reviewed; 200 AA.
AC P20294;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 25-MAY-2022, entry version 144.
DE RecName: Full=Ciliary neurotrophic factor;
DE Short=CNTF;
GN Name=Cntf;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX PubMed=2594085; DOI=10.1038/342920a0;
RA Stoeckli K.A., Lottspeich F., Sendtner M., Masiakowski P., Carroll P.,
RA Goetz R., Lindholm D., Thoenen H.;
RT "Molecular cloning, expression and regional distribution of rat ciliary
RT neurotrophic factor.";
RL Nature 342:920-923(1989).
CC -!- FUNCTION: CNTF is a survival factor for various neuronal cell types.
CC Seems to prevent the degeneration of motor axons after axotomy.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- TISSUE SPECIFICITY: Nervous system.
CC -!- SIMILARITY: Belongs to the CNTF family. {ECO:0000305}.
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DR EMBL; X17457; CAA35500.1; -; mRNA.
DR PIR; S08144; UNRTCF.
DR RefSeq; NP_037298.1; NM_013166.1.
DR AlphaFoldDB; P20294; -.
DR SMR; P20294; -.
DR STRING; 10116.ENSRNOP00000016690; -.
DR PaxDb; P20294; -.
DR GeneID; 25707; -.
DR KEGG; rno:25707; -.
DR UCSC; RGD:2370; rat.
DR CTD; 1270; -.
DR RGD; 2370; Cntf.
DR eggNOG; ENOG502S4XX; Eukaryota.
DR InParanoid; P20294; -.
DR OrthoDB; 1466128at2759; -.
DR PhylomeDB; P20294; -.
DR Reactome; R-RNO-6788467; IL-6-type cytokine receptor ligand interactions.
DR PRO; PR:P20294; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0030424; C:axon; IDA:RGD.
DR GO; GO:0005829; C:cytosol; IDA:RGD.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0043025; C:neuronal cell body; IDA:RGD.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0032838; C:plasma membrane bounded cell projection cytoplasm; IDA:RGD.
DR GO; GO:0005127; F:ciliary neurotrophic factor receptor binding; IPI:RGD.
DR GO; GO:0005125; F:cytokine activity; IDA:RGD.
DR GO; GO:0008083; F:growth factor activity; ISO:RGD.
DR GO; GO:0005138; F:interleukin-6 receptor binding; ISO:RGD.
DR GO; GO:0044877; F:protein-containing complex binding; IPI:RGD.
DR GO; GO:0048143; P:astrocyte activation; IDA:RGD.
DR GO; GO:0070120; P:ciliary neurotrophic factor-mediated signaling pathway; ISO:RGD.
DR GO; GO:0060081; P:membrane hyperpolarization; IDA:RGD.
DR GO; GO:0048644; P:muscle organ morphogenesis; ISO:RGD.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IDA:RGD.
DR GO; GO:1901215; P:negative regulation of neuron death; IDA:RGD.
DR GO; GO:0046533; P:negative regulation of photoreceptor cell differentiation; ISO:RGD.
DR GO; GO:0007399; P:nervous system development; IDA:RGD.
DR GO; GO:0048666; P:neuron development; ISO:RGD.
DR GO; GO:0048691; P:positive regulation of axon extension involved in regeneration; IDA:CAFA.
DR GO; GO:0048680; P:positive regulation of axon regeneration; IDA:RGD.
DR GO; GO:0030307; P:positive regulation of cell growth; IDA:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR GO; GO:0046887; P:positive regulation of hormone secretion; IDA:RGD.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IDA:RGD.
DR GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IDA:RGD.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IDA:RGD.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IDA:RGD.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IDA:RGD.
DR GO; GO:0060075; P:regulation of resting membrane potential; IDA:RGD.
DR GO; GO:0046668; P:regulation of retinal cell programmed cell death; ISO:RGD.
DR GO; GO:0051602; P:response to electrical stimulus; IEP:RGD.
DR GO; GO:0009642; P:response to light intensity; IEP:RGD.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000151; Ciliary_neurotrophic_fac_CNTF.
DR PANTHER; PTHR15196; PTHR15196; 1.
DR Pfam; PF01110; CNTF; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Developmental protein; Differentiation;
KW Direct protein sequencing; Growth factor; Neurogenesis; Reference proteome.
FT CHAIN 1..200
FT /note="Ciliary neurotrophic factor"
FT /id="PRO_0000149523"
SQ SEQUENCE 200 AA; 22854 MW; FC95A25FE1A1DE3D CRC64;
MAFAEQTPLT LHRRDLCSRS IWLARKIRSD LTALMESYVK HQGLNKNINL DSVDGVPVAS
TDRWSEMTEA ERLQENLQAY RTFQGMLTKL LEDQRVHFTP TEGDFHQAIH TLMLQVSAFA
YQLEELMVLL EQKIPENEAD GMPATVGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRVIS
SHQMGISALE SHYGAKDKQM