ACL6B_RAT
ID ACL6B_RAT Reviewed; 426 AA.
AC P86173; A6J021;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 13-OCT-2009, sequence version 2.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Actin-like protein 6B {ECO:0000250|UniProtKB:O94805};
DE AltName: Full=BRG1-associated factor 53B;
DE Short=BAF53B;
GN Name=Actl6b {ECO:0000250|UniProtKB:O94805};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=12368262; DOI=10.1101/gad.992102;
RA Olave I., Wang W., Xue Y., Kuo A., Crabtree G.R.;
RT "Identification of a polymorphic, neuron-specific chromatin remodeling
RT complex.";
RL Genes Dev. 16:2509-2517(2002).
RN [3] {ECO:0000305}
RP IDENTIFICATION BY MASS SPECTROMETRY.
RA Maurya D.K., Bhargava P.;
RL Submitted (DEC-2008) to UniProtKB.
CC -!- FUNCTION: Involved in transcriptional activation and repression of
CC select genes by chromatin remodeling (alteration of DNA-nucleosome
CC topology). Component of SWI/SNF chromatin remodeling complexes that
CC carry out key enzymatic activities, changing chromatin structure by
CC altering DNA-histone contacts within a nucleosome in an ATP-dependent
CC manner. Belongs to the neuron-specific chromatin remodeling complex
CC (nBAF complex), as such plays a role in remodeling mononucleosomes in
CC an ATP-dependent fashion, and is required for postmitotic neural
CC development and dendritic outgrowth. During neural development a switch
CC from a stem/progenitor to a postmitotic chromatin remodeling mechanism
CC occurs as neurons exit the cell cycle and become committed to their
CC adult state. The transition from proliferating neural stem/progenitor
CC cells to postmitotic neurons requires a switch in subunit composition
CC of the npBAF and nBAF complexes. As neural progenitors exit mitosis and
CC differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A
CC and PHF10/BAF45A, are exchanged for homologous alternative
CC ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-
CC specific complexes (nBAF). The npBAF complex is essential for the self-
CC renewal/proliferative capacity of the multipotent neural stem cells.
CC The nBAF complex along with CREST plays a role regulating the activity
CC of genes essential for dendrite growth. ACTL6B/BAF53B is not essential
CC for assembly of the nBAF complex but is required for targeting the
CC complex and CREST to the promoter of genes essential for dendritic
CC growth. Essential for neuronal maturation and dendrite development (By
CC similarity). {ECO:0000250|UniProtKB:O94805,
CC ECO:0000250|UniProtKB:Q99MR0}.
CC -!- SUBUNIT: Component of the multiprotein chromatin-remodeling complexes
CC SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The
CC canonical complex contains a catalytic subunit (either
CC SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1,
CC ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47.
CC Other subunits specific to each of the complexes may also be present
CC permitting several possible combinations developmentally and tissue
CC specific (By similarity).Component of the BAF complex, which includes
CC at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM,
CC SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57,
CC SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more
CC SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (By similarity).
CC Component of neuron-specific chromatin remodeling complex (nBAF
CC complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B,
CC SMARCD1/BAF60A or SMARCD2/BAF60B or SMARCD3/BAF60C,
CC SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47,
CC SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B,
CC DPF3/BAF45C, ACTL6B/BAF53B and actin (ACTB). Note that the nBAF complex
CC is polymorphic in regard to the ATPase, SMARCA2 and SMARCA4 occupying
CC mutually exclusive positions (By similarity). May be a component of the
CC SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of
CC SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B,
CC SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C,
CC SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin
CC (By similarity). {ECO:0000250|UniProtKB:O94805,
CC ECO:0000250|UniProtKB:Q99MR0}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12368262}.
CC -!- TISSUE SPECIFICITY: Expressed in hippocampus, exclusively in neurons,
CC but not in glial cells. {ECO:0000269|PubMed:12368262}.
CC -!- SIMILARITY: Belongs to the actin family. {ECO:0000255}.
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DR EMBL; CH473973; EDM13260.1; -; Genomic_DNA.
DR RefSeq; NP_001099387.2; NM_001105917.1.
DR AlphaFoldDB; P86173; -.
DR SMR; P86173; -.
DR STRING; 10116.ENSRNOP00000001910; -.
DR iPTMnet; P86173; -.
DR PhosphoSitePlus; P86173; -.
DR jPOST; P86173; -.
DR PaxDb; P86173; -.
DR ABCD; P86173; 1 sequenced antibody.
DR GeneID; 288563; -.
DR KEGG; rno:288563; -.
DR UCSC; RGD:1307763; rat.
DR CTD; 51412; -.
DR RGD; 1307763; Actl6b.
DR VEuPathDB; HostDB:ENSRNOG00000001408; -.
DR eggNOG; KOG0679; Eukaryota.
DR InParanoid; P86173; -.
DR OMA; MWMSKSE; -.
DR OrthoDB; 649708at2759; -.
DR PhylomeDB; P86173; -.
DR TreeFam; TF312863; -.
DR Reactome; R-RNO-3214858; RMTs methylate histone arginines.
DR Reactome; R-RNO-8939243; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.
DR PRO; PR:P86173; -.
DR Proteomes; UP000002494; Chromosome 12.
DR Proteomes; UP000234681; Chromosome 12.
DR Bgee; ENSRNOG00000001408; Expressed in frontal cortex and 4 other tissues.
DR ExpressionAtlas; P86173; baseline and differential.
DR Genevisible; P86173; RN.
DR GO; GO:0071565; C:nBAF complex; ISS:UniProtKB.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0016514; C:SWI/SNF complex; ISO:RGD.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; ISO:RGD.
DR GO; GO:0016358; P:dendrite development; ISS:UniProtKB.
DR GO; GO:0043967; P:histone H4 acetylation; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; ISO:RGD.
DR GO; GO:0042551; P:neuron maturation; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021510; P:spinal cord development; IEP:RGD.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR004001; Actin_CS.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR Pfam; PF00022; Actin; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS00432; ACTINS_2; 1.
PE 1: Evidence at protein level;
KW Chromatin regulator; Neurogenesis; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..426
FT /note="Actin-like protein 6B"
FT /id="PRO_0000365478"
FT REGION 39..82
FT /note="Essential for mediating its function in dendritic
FT development; may contribute to neuronal-specific targeting"
FT /evidence="ECO:0000250|UniProtKB:Q99MR0"
SQ SEQUENCE 426 AA; 46891 MW; 7B9CD9B70E1304CE CRC64;
MSGGVYGGDE VGALVFDIGS FSVRAGYAGE DCPKADFPTT VGLLAAEEGG GLELEGEKEK
KGKIFHIDTN ALHVPRDGAE VMSPLKNGMI EDWECFRAIL DHTYSKHVKS EPNLHPVLMS
EAPWNTRAKR EKLTELMFEQ YNIPAFFLCK TAVLTAFANG RSTGLVLDSG ATHTTAIPVH
DGYVLQQGIV KSPLAGDFIS MQCRELFQEM AIDIIPPYMI AAKEPVREGA PPNWKKKEKL
PQVSKSWHNY MCNEVIQDFQ ASVLQVSDSP YDEQVAAQMP TVHYEMPNGY NTDYGAERLR
IPEGLFDPSN VKGLSGNTML GVGHVVTTSI GMCDIDIRPG LYGSVIVTGG NTLLQGFTDR
LNRELSQKTP PSMRLKLIAS NSTMERKFSP WIGGSILASL GTFQQMWISK QEYEEGGKQC
VERKCP
