CNTP3_HUMAN
ID CNTP3_HUMAN Reviewed; 1288 AA.
AC Q9BZ76; B1AMA0; Q9C0E9;
DT 05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 3.
DT 03-AUG-2022, entry version 185.
DE RecName: Full=Contactin-associated protein-like 3;
DE AltName: Full=Cell recognition molecule Caspr3;
DE Flags: Precursor;
GN Name=CNTNAP3; Synonyms=CASPR3, KIAA1714;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=12093160; DOI=10.1006/mcne.2002.1110;
RA Spiegel I., Salomon D., Erne B., Schaeren-Wiemers N., Peles E.;
RT "Caspr3 and Caspr4, two novel members of the Caspr family are expressed in
RT the nervous system and interact with PDZ domains.";
RL Mol. Cell. Neurosci. 20:283-297(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT HIS-845.
RC TISSUE=Brain;
RX PubMed=11214970; DOI=10.1093/dnares/7.6.347;
RA Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:347-355(2000).
RN [3]
RP SEQUENCE REVISION.
RA Nagase T., Kikuno R., Yamakawa H., Ohara O.;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Single-
CC pass type I membrane protein {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BZ76-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BZ76-2; Sequence=VSP_003535, VSP_003536;
CC -!- SIMILARITY: Belongs to the neurexin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB21805.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF333769; AAG52889.2; -; mRNA.
DR EMBL; AB051501; BAB21805.2; ALT_INIT; mRNA.
DR EMBL; AL162501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL353729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS6616.1; -. [Q9BZ76-1]
DR RefSeq; NP_387504.2; NM_033655.3. [Q9BZ76-1]
DR AlphaFoldDB; Q9BZ76; -.
DR SMR; Q9BZ76; -.
DR BioGRID; 123011; 209.
DR IntAct; Q9BZ76; 34.
DR STRING; 9606.ENSP00000297668; -.
DR GlyGen; Q9BZ76; 9 sites.
DR iPTMnet; Q9BZ76; -.
DR PhosphoSitePlus; Q9BZ76; -.
DR BioMuta; CNTNAP3; -.
DR DMDM; 209572752; -.
DR EPD; Q9BZ76; -.
DR MassIVE; Q9BZ76; -.
DR MaxQB; Q9BZ76; -.
DR PaxDb; Q9BZ76; -.
DR PeptideAtlas; Q9BZ76; -.
DR PRIDE; Q9BZ76; -.
DR ProteomicsDB; 79776; -. [Q9BZ76-1]
DR ProteomicsDB; 79777; -. [Q9BZ76-2]
DR Antibodypedia; 12082; 67 antibodies from 21 providers.
DR DNASU; 79937; -.
DR Ensembl; ENST00000297668.11; ENSP00000297668.6; ENSG00000106714.18. [Q9BZ76-1]
DR GeneID; 79937; -.
DR KEGG; hsa:79937; -.
DR MANE-Select; ENST00000297668.11; ENSP00000297668.6; NM_033655.5; NP_387504.2.
DR UCSC; uc004abi.4; human. [Q9BZ76-1]
DR CTD; 79937; -.
DR DisGeNET; 79937; -.
DR GeneCards; CNTNAP3; -.
DR HGNC; HGNC:13834; CNTNAP3.
DR HPA; ENSG00000106714; Low tissue specificity.
DR MIM; 610517; gene.
DR neXtProt; NX_Q9BZ76; -.
DR OpenTargets; ENSG00000106714; -.
DR PharmGKB; PA134963289; -.
DR VEuPathDB; HostDB:ENSG00000106714; -.
DR eggNOG; KOG3516; Eukaryota.
DR GeneTree; ENSGT00940000160228; -.
DR HOGENOM; CLU_003504_1_0_1; -.
DR InParanoid; Q9BZ76; -.
DR OMA; YDGPLCS; -.
DR OrthoDB; 338397at2759; -.
DR PhylomeDB; Q9BZ76; -.
DR TreeFam; TF321823; -.
DR PathwayCommons; Q9BZ76; -.
DR SignaLink; Q9BZ76; -.
DR BioGRID-ORCS; 79937; 15 hits in 989 CRISPR screens.
DR ChiTaRS; CNTNAP3; human.
DR GenomeRNAi; 79937; -.
DR Pharos; Q9BZ76; Tbio.
DR PRO; PR:Q9BZ76; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q9BZ76; protein.
DR Bgee; ENSG00000106714; Expressed in mucosa of stomach and 99 other tissues.
DR ExpressionAtlas; Q9BZ76; baseline and differential.
DR Genevisible; Q9BZ76; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0008037; P:cell recognition; NAS:UniProtKB.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd00110; LamG; 4.
DR InterPro; IPR028873; CASPR3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR15036:SF36; PTHR15036:SF36; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF02210; Laminin_G_2; 4.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00282; LamG; 4.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF49899; SSF49899; 4.
DR SUPFAM; SSF56496; SSF56496; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell adhesion; Cell membrane; Disulfide bond;
KW EGF-like domain; Glycoprotein; Membrane; Reference proteome; Repeat;
KW Secreted; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..1288
FT /note="Contactin-associated protein-like 3"
FT /id="PRO_0000019509"
FT TOPO_DOM 26..1245
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1246..1266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1267..1288
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 31..177
FT /note="F5/8 type C"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00081"
FT DOMAIN 183..364
FT /note="Laminin G-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 370..545
FT /note="Laminin G-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 551..583
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 584..792
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT DOMAIN 793..958
FT /note="Laminin G-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 962..996
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1015..1203
FT /note="Laminin G-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT REGION 1215..1236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 285
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 359
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 441
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 497
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 623
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 706
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1023
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1073
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1120
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 31..177
FT /evidence="ECO:0000250"
FT DISULFID 332..364
FT /evidence="ECO:0000250"
FT DISULFID 513..545
FT /evidence="ECO:0000250"
FT DISULFID 551..562
FT /evidence="ECO:0000250"
FT DISULFID 556..571
FT /evidence="ECO:0000250"
FT DISULFID 573..583
FT /evidence="ECO:0000250"
FT DISULFID 931..958
FT /evidence="ECO:0000250"
FT DISULFID 962..975
FT /evidence="ECO:0000250"
FT DISULFID 969..984
FT /evidence="ECO:0000250"
FT DISULFID 986..996
FT /evidence="ECO:0000250"
FT DISULFID 1167..1203
FT /evidence="ECO:0000250"
FT VAR_SEQ 1120..1127
FT /note="NQSTKKQV -> IPQMQKSN (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11214970"
FT /id="VSP_003535"
FT VAR_SEQ 1128..1288
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11214970"
FT /id="VSP_003536"
FT VARIANT 628
FT /note="A -> S (in dbSNP:rs1758272)"
FT /id="VAR_046710"
FT VARIANT 845
FT /note="R -> H (in dbSNP:rs7852039)"
FT /evidence="ECO:0000269|PubMed:11214970"
FT /id="VAR_046711"
FT CONFLICT 21
FT /note="S -> R (in Ref. 1; AAG52889)"
FT /evidence="ECO:0000305"
FT CONFLICT 33
FT /note="A -> S (in Ref. 1; AAG52889)"
FT /evidence="ECO:0000305"
FT CONFLICT 89
FT /note="M -> I (in Ref. 1; AAG52889)"
FT /evidence="ECO:0000305"
FT CONFLICT 711
FT /note="S -> Y (in Ref. 1; AAG52889 and 2; BAB21805)"
FT /evidence="ECO:0000305"
FT CONFLICT 714
FT /note="G -> V (in Ref. 2; BAB21805)"
FT /evidence="ECO:0000305"
FT CONFLICT 769..771
FT /note="AGR -> TGQ (in Ref. 1; AAG52889)"
FT /evidence="ECO:0000305"
FT CONFLICT 777
FT /note="A -> D (in Ref. 1; AAG52889)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1288 AA; 140690 MW; F41F1CE8A83D417E CRC64;
MASVAWAVLK VLLLLPTQTW SPVGAGNPPD CDAPLASALP RSSFSSSSEL SSSHGPGFSR
LNRRDGAGGW TPLVSNKYQW LQIDLGERME VTAVATQGGY GSSDWVTSYL LMFSDGGRNW
KQYRREESIW GFPGNTNADS VVHYRLQPPF EARFLRFLPL AWNPRGRIGM RIEVYGCAYK
SEVVYFDGQS ALLYRLDKKP LKPIRDVISL KFKAMQSNGI LLHREGQHGN HITLELIKGK
LVFFLNSGNA KLPSTIAPVT LTLGSLLDDQ HWHSVLIELL DTQVNFTVDK HTHHFQAKGD
SSYLDLNFEI SFGGIPTPGR SRAFRRKSFH GCLENLYYNG VDVTELAKKH KPQILMMGNV
SFSCPQPQTV PVTFLSSRSY LALPGNSGED KVSVTFQFRT WNRAGHLLFG ELRRGSGSFV
LFLKDGKLKL SLFQPGQSPR NVTAGAGLND GQWHSVSFSA KWSHMNVVVD DDTAVQPLVA
VLIDSGDTYY FGGCLDNSSG SGCKSPLGGF QGCLRLITIG DKAVDPILVQ QGALGSFRDL
QIDSCGITDR CLPSYCEHGG ECSQSWDTFS CDCLGTGYTG ETCHSSLYEQ SCEAHKHRGN
PSGLYYIDAD GSGPLGPFLV YCNMTADAAW TVVQHGGPDA VTLRGAPSGH PRSAVSFAYA
AGAGQLRSAV NLAERCEQRL ALRCGTARRP DSRDGTPLSW WVGRTNETHT SWGGSLPDAQ
KCTCGLEGNC IDSQYYCNCD AGRNEWTSDT IVLSQKEHLP VTQIVMTDAG RPHSEAAYTL
GPLLCRGDQS FWNSASFNTE TSYLHFPAFH GELTADVCFF FKTTVSSGVF MENLGITDFI
RIELRAPTEV TFSFDVGNGP CEVTVQSPTP FNDNQWHHVR AERNVKGASL QVDQLPQKMQ
PAPADGHVRL QLNSQLFIGG TATRQRGFLG CIRSLQLNGV ALDLEERATV TPGVEPGCAG
HCSTYGHLCR NGGRCREKRR GVTCDCAFSA YDGPFCSNEI SAYFATGSSM TYHFQEHYTL
SENSSSLVSS LHRDVTLTRE MITLSFRTTR TPSLLLYVSS FYEEYLSVIL ANNGSLQIRY
KLDRHQNPDA FTFDFKNMAD GQLHQVKINR EEAVVMVEVN QSTKKQVILS SGTEFNAVKS
LILGKVLEAA GADPDTRRAA TSGFTGCLSA VRFGRAAPLK AALRPSGPSR VTVRGHVAPM
ARCAAGAASG SPARELAPRL AGGAGRSGPA DEGEPLVNAD RRDSAVIGGV IAVVIFILLC
ITAIAIRIYQ QRKLRKENES KVSKKEEC
