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ACL7A_BOVIN
ID   ACL7A_BOVIN             Reviewed;         438 AA.
AC   Q32KZ2;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Actin-like protein 7A;
GN   Name=ACTL7A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play an important role in formation and fusion of Golgi-
CC       derived vesicles during acrosome biogenesis.
CC       {ECO:0000250|UniProtKB:Q9QY84}.
CC   -!- SUBUNIT: Interacts (via N-terminus) with TES (via LIM domain 2).
CC       Heterodimer with TES; the heterodimer interacts with ENAH to form a
CC       heterotrimer. Interacts with ACTL9. {ECO:0000250|UniProtKB:Q9Y615}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q9QY84}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:Q9QY84}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9QY84}. Nucleus {ECO:0000250|UniProtKB:Q9QY84}.
CC       Note=Detected at the Golgi apparatus during acrosome biogenesis.
CC       Detected at the subacrosomal layer in round spermatids. Detected in
CC       sperm head and tail. {ECO:0000250|UniProtKB:Q9QY84}.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; BC109843; AAI09844.1; -; mRNA.
DR   RefSeq; NP_001033659.1; NM_001038570.1.
DR   AlphaFoldDB; Q32KZ2; -.
DR   SMR; Q32KZ2; -.
DR   STRING; 9913.ENSBTAP00000025933; -.
DR   PaxDb; Q32KZ2; -.
DR   PRIDE; Q32KZ2; -.
DR   Ensembl; ENSBTAT00000025933; ENSBTAP00000025933; ENSBTAG00000019468.
DR   GeneID; 540296; -.
DR   KEGG; bta:540296; -.
DR   CTD; 10881; -.
DR   VEuPathDB; HostDB:ENSBTAG00000019468; -.
DR   VGNC; VGNC:25577; ACTL7A.
DR   eggNOG; KOG0676; Eukaryota.
DR   GeneTree; ENSGT00940000162158; -.
DR   HOGENOM; CLU_027965_0_2_1; -.
DR   InParanoid; Q32KZ2; -.
DR   OMA; MNNSGKH; -.
DR   OrthoDB; 964605at2759; -.
DR   TreeFam; TF354237; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000019468; Expressed in semen and 18 other tissues.
DR   GO; GO:0001669; C:acrosomal vesicle; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005869; C:dynactin complex; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR   GO; GO:0031514; C:motile cilium; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001675; P:acrosome assembly; ISS:UniProtKB.
DR   GO; GO:0009566; P:fertilization; ISS:UniProtKB.
DR   GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR027679; ACTL7A.
DR   InterPro; IPR031769; ACTL7A_N.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   PANTHER; PTHR11937:SF167; PTHR11937:SF167; 1.
DR   Pfam; PF00022; Actin; 1.
DR   Pfam; PF16840; ACTL7A_N; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Fertilization; Golgi apparatus; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..438
FT                   /note="Actin-like protein 7A"
FT                   /id="PRO_0000282828"
FT   REGION          36..56
FT                   /note="Required for interaction with TES"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y615"
SQ   SEQUENCE   438 AA;  49016 MW;  88A741F07636C930 CRC64;
     MALESVWAPQ AAVIGDGLSE RVGEQASPQT QVLQTASLKD GPAKRAVWVR RDHSEPEPTT
     SPEVKKPKLE LTKAVVVDLG TGYCKCGFAG LPKPTHRIST TVGKPYMETA KTGDNRKETF
     VGHELINPEV RLKLINPLRH GIIVDWDTVQ DIWEYLFHQE MKIAPEEHAV LVSDPPLSPH
     TNREKYAEML FETFKTPAMH IAYQSRLSMY SYGRTSGLVV EVGHGVSYVV PIYEGYPLPS
     ITGRLDYAGS DLTTYLMCLM NTAGKHFTEG QLGIVEDIKK KCCFVALDPI EEKKVPATEH
     MIQYTLPDGQ AIYLCQERFL CSEMFFKPSL IKSMQLGLHT QTVSCLNKCD IALKRDLMGN
     ILLCGGSTML SGFPNRLQKE LSSMCPNDTP QVSVLPERDT AVWTGGSILA SLQGFQPLWV
     HRSEYEEHGP FFLYRRCF
 
 
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