ID   CNU_SHIFL               Reviewed;          71 AA.
AC   P64470; P76179;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=OriC-binding nucleoid-associated protein;
DE   AltName: Full=H-NS/StpA-binding protein 2;
DE   AltName: Full=Transcription modulator YdgT;
GN   Name=cnu; Synonyms=ydgT; OrderedLocusNames=SF1650, S1782;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Modifies the set of genes regulated by H-NS; Hha and cnu
CC       (YdgT) increase the number of genes bound by H-NS/StpA and may also
CC       modulate the oligomerization of the H-NS/StpA-complex on DNA. The
CC       complex formed with H-NS binds to the specific 26-bp cnb site in the
CC       origin of replication oriC. {ECO:0000250|UniProtKB:P64467}.
CC   -!- SUBUNIT: Forms complexes with both H-NS and StpA.
CC       {ECO:0000250|UniProtKB:P64467}.
CC   -!- SIMILARITY: Belongs to the Hha/YmoA/Cnu family. {ECO:0000305}.
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DR   EMBL; AE005674; AAN43232.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP17118.1; -; Genomic_DNA.
DR   RefSeq; NP_707525.1; NC_004337.2.
DR   RefSeq; WP_000217950.1; NZ_WPGW01000065.1.
DR   AlphaFoldDB; P64470; -.
DR   SMR; P64470; -.
DR   STRING; 198214.SF1650; -.
DR   EnsemblBacteria; AAN43232; AAN43232; SF1650.
DR   EnsemblBacteria; AAP17118; AAP17118; S1782.
DR   GeneID; 1023375; -.
DR   GeneID; 66674483; -.
DR   KEGG; sfl:SF1650; -.
DR   KEGG; sfx:S1782; -.
DR   PATRIC; fig|198214.7.peg.1946; -.
DR   HOGENOM; CLU_190629_0_0_6; -.
DR   OMA; PKSVWHF; -.
DR   OrthoDB; 1947329at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1280.40; -; 1.
DR   InterPro; IPR007985; Hemolysn_expr_modulating_HHA.
DR   InterPro; IPR036666; HHA_sf.
DR   Pfam; PF05321; HHA; 1.
DR   SUPFAM; SSF68989; SSF68989; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..71
FT                   /note="OriC-binding nucleoid-associated protein"
FT                   /id="PRO_0000201739"
FT   SITE            44
FT                   /note="Interacts with H-NS"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   71 AA;  8417 MW;  CE9FF2E890E78219 CRC64;
     MTVQDYLLKF RKISSLESLE KLYDHLNYTL TDDQELINMY RAADHRRAEL VSGGRLFDLG
     QVPKSVWHYV Q