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ACL7A_MACFA
ID   ACL7A_MACFA             Reviewed;         435 AA.
AC   Q4R6Q3; Q4R864;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Actin-like protein 7A;
GN   Name=ACTL7A; ORFNames=QtsA-13302, QtsA-17410;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play an important role in formation and fusion of Golgi-
CC       derived vesicles during acrosome biogenesis.
CC       {ECO:0000250|UniProtKB:Q9QY84}.
CC   -!- SUBUNIT: Interacts (via N-terminus) with TES (via LIM domain 2).
CC       Heterodimer with TES; the heterodimer interacts with ENAH to form a
CC       heterotrimer. Interacts with ACTL9. {ECO:0000250|UniProtKB:Q9Y615}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q9QY84}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:Q9QY84}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9QY84}. Nucleus {ECO:0000250|UniProtKB:Q9QY84}.
CC       Note=Detected at the Golgi apparatus during acrosome biogenesis.
CC       Detected at the subacrosomal layer in round spermatids. Detected in
CC       sperm head and tail. {ECO:0000250|UniProtKB:Q9QY84}.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; AB168594; BAE00708.1; -; mRNA.
DR   EMBL; AB169127; BAE01221.1; -; mRNA.
DR   RefSeq; NP_001270639.1; NM_001283710.1.
DR   RefSeq; XP_015291978.1; XM_015436492.1.
DR   AlphaFoldDB; Q4R6Q3; -.
DR   SMR; Q4R6Q3; -.
DR   STRING; 9541.XP_005581177.1; -.
DR   GeneID; 101867093; -.
DR   CTD; 10881; -.
DR   eggNOG; KOG0676; Eukaryota.
DR   OrthoDB; 964605at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0001669; C:acrosomal vesicle; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001675; P:acrosome assembly; ISS:UniProtKB.
DR   GO; GO:0009566; P:fertilization; ISS:UniProtKB.
DR   GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR027679; ACTL7A.
DR   InterPro; IPR031769; ACTL7A_N.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   PANTHER; PTHR11937:SF167; PTHR11937:SF167; 1.
DR   Pfam; PF00022; Actin; 1.
DR   Pfam; PF16840; ACTL7A_N; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Fertilization; Golgi apparatus; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..435
FT                   /note="Actin-like protein 7A"
FT                   /id="PRO_0000260761"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          29..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          31..51
FT                   /note="Required for interaction with TES"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y615"
FT   COMPBIAS        39..65
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        291
FT                   /note="R -> K (in Ref. 1; BAE00708)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   435 AA;  48734 MW;  95E87836493EE605 CRC64;
     MWAPPAAIMG DGPAKKVGNQ APLQTQALQT ASLRDGPAKR AVWVRRRSSE PQEPTESKAA
     KERPKQEVTK AVVVDLGTGY CKCGFAGLPR PTHKISTMVG KPYMETAKTG DNRKETFVGQ
     ELNNTNVHLK LVNPLRHGII VDWDTVQDIW EYLFRQEMKI APEEHAVLVS DPPLSPHTNR
     EKYAEMLFEA FNTPAMHIAY QSRLSMYSYG RTSGLVVEVG HGVSYVVPIY EGYPLPSITG
     RLDYAGSDLT AYLLGLLNSA GNEFTQDQMG IVEDIKKKCC FVALDPTEEK RVPLSEHTIR
     YVLPDGKEIQ LCQERFLCSE MFFKPSLIKS MQLGLHTQTV SCLNKCDIAL KRDLMGNILL
     CGGSTMLSGF PNRLQKELSS MCPNDTPQVN VLPERDSAVW TGGSILASLQ GFQPLWVHRF
     EYEEHGPFFL YRRCF
 
 
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