CO039_MOUSE
ID CO039_MOUSE Reviewed; 1023 AA.
AC Q3TEI4; Q148A1; Q3TMF2; Q3U253; Q3UM75; Q9DA93;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Uncharacterized protein C15orf39 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=NOD; TISSUE=Dendritic cell, Lung, Mammary gland, Testis, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-912, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-493; SER-494; SER-964 AND
RP SER-972, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3TEI4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3TEI4-2; Sequence=VSP_019542;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to competing donor splice site.
CC {ECO:0000305}.
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DR EMBL; AK006055; BAB24386.1; -; mRNA.
DR EMBL; AK145074; BAE26223.1; -; mRNA.
DR EMBL; AK155487; BAE33289.1; -; mRNA.
DR EMBL; AK165963; BAE38490.1; -; mRNA.
DR EMBL; AK169617; BAE41264.1; -; mRNA.
DR EMBL; BC118527; AAI18528.1; -; mRNA.
DR CCDS; CCDS23219.1; -. [Q3TEI4-1]
DR RefSeq; NP_083096.1; NM_028820.2. [Q3TEI4-1]
DR RefSeq; XP_006511579.1; XM_006511516.2. [Q3TEI4-1]
DR AlphaFoldDB; Q3TEI4; -.
DR STRING; 10090.ENSMUSP00000034846; -.
DR iPTMnet; Q3TEI4; -.
DR PhosphoSitePlus; Q3TEI4; -.
DR EPD; Q3TEI4; -.
DR MaxQB; Q3TEI4; -.
DR PaxDb; Q3TEI4; -.
DR PRIDE; Q3TEI4; -.
DR Antibodypedia; 50503; 72 antibodies from 16 providers.
DR Ensembl; ENSMUST00000034846; ENSMUSP00000034846; ENSMUSG00000032300. [Q3TEI4-1]
DR Ensembl; ENSMUST00000215298; ENSMUSP00000150452; ENSMUSG00000032300. [Q3TEI4-2]
DR GeneID; 74211; -.
DR KEGG; mmu:74211; -.
DR UCSC; uc009puq.2; mouse. [Q3TEI4-1]
DR UCSC; uc009pur.2; mouse. [Q3TEI4-2]
DR MGI; MGI:1921461; 1700017B05Rik.
DR VEuPathDB; HostDB:ENSMUSG00000032300; -.
DR eggNOG; ENOG502QW16; Eukaryota.
DR GeneTree; ENSGT00390000002672; -.
DR HOGENOM; CLU_322865_0_0_1; -.
DR InParanoid; Q3TEI4; -.
DR OMA; EWLEMAG; -.
DR OrthoDB; 367030at2759; -.
DR PhylomeDB; Q3TEI4; -.
DR TreeFam; TF338672; -.
DR BioGRID-ORCS; 74211; 5 hits in 71 CRISPR screens.
DR PRO; PR:Q3TEI4; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q3TEI4; protein.
DR Bgee; ENSMUSG00000032300; Expressed in spermatocyte and 213 other tissues.
DR ExpressionAtlas; Q3TEI4; baseline and differential.
DR Genevisible; Q3TEI4; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR InterPro; IPR037656; DUF5525.
DR PANTHER; PTHR28422; PTHR28422; 1.
DR Pfam; PF17663; DUF5525; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..1023
FT /note="Uncharacterized protein C15orf39 homolog"
FT /id="PRO_0000244344"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 907..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1002..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..532
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..724
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 959..974
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 17
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZRI6"
FT MOD_RES 206
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZRI6"
FT MOD_RES 383
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZRI6"
FT MOD_RES 389
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZRI6"
FT MOD_RES 493
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 494
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 912
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT MOD_RES 964
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 972
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 46..902
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_019542"
FT CONFLICT 230
FT /note="S -> G (in Ref. 1; BAE26223/BAE33289/BAE41264)"
FT /evidence="ECO:0000305"
FT CONFLICT 313
FT /note="G -> S (in Ref. 1; BAE26223)"
FT /evidence="ECO:0000305"
FT CONFLICT 342
FT /note="L -> F (in Ref. 1; BAE26223)"
FT /evidence="ECO:0000305"
FT CONFLICT 387
FT /note="G -> E (in Ref. 1; BAE41264)"
FT /evidence="ECO:0000305"
FT CONFLICT 653
FT /note="T -> P (in Ref. 1; BAE26223/BAE33289/BAE41264)"
FT /evidence="ECO:0000305"
FT CONFLICT 736
FT /note="V -> A (in Ref. 1; BAE26223/BAE33289/BAE41264)"
FT /evidence="ECO:0000305"
FT CONFLICT 1009
FT /note="S -> P (in Ref. 1; BAE26223/BAE33289/BAE41264)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1023 AA; 108224 MW; 154DC01262A6FDD3 CRC64;
MAEKRPLGPL GPMMYGKLPR LEPDPGPGHS LPLSASSQDS CNYKGAYFSC PIGGTSKAGS
ERLASWTPYP SLYPTGVAGS PLRGDNLLTN CLLYRPPTEG SEKIQDSSEL LPFGPQAHAY
PGPPLAAPKP VYRNPLCYGL STCLGDGGTK RSLDGDWTLV TGPLLPSADP PCPLATAPGK
GQPLDGTFLR GLPSGGPGKD SSLPFSPCQA FLEKYRTIQS TGFLASKYTS PYPGDAKQAM
SEGPSSPWTQ LAQPLGPPCQ DAVAAHYPLP PPPQALPCPP SCHPEKQGSY GSLLPLPPLG
AHKGAAYQAG GLGSPYLRQQ APQAPYMPPL GIDSYSYSSA PLPAPSPGLK LEPPLAPRCP
LDFVPQTLGF PYARDDLSLY GASPGLGGTP PSHSQNSVQP VPQPGAFQRA CQPLPASQPC
SEPVRPAEKP TPEAQEKMWL PSCRKEQLQP RPNERPGVPI VIRDSPVPRT SPALHPCAKE
RQSVPQKDAR PPSSPPMPVI DNVFSLAPYR DYLDVQTPEP RAERDSAPAT SKSQDKDCKG
NLPAQDGASR SHCSLREEVA LDLSVKKTMA EGVPVKVPSP EVHEKPAEAV DGPGIENTVS
GLPGLKKMVT EIPEVTAEAT PRTNFHSSVA FMFRKFKILR TAPVPAAIVS SPTTPAPVPA
PAPAQPVPNP PSVPVGLQIL TQPLPVACFN LALPSPPAIV ASPAPASAPP PSPAPAPAPA
SGPAPSSAQV PTAAPVDSPE QHFTGLHTSL CDAISGSVAH SPPEKLREWL ETTGPWGQAA
WQDCQGVQGL LGKLLSQLQK FVCTQRCPFP HVVRAGAIFV PIHLVKERLF PKLPPASVDH
VLQDHRVELR PTTLSEERAL RERALHGCTS RMLKLLALRQ LPDIYPDLLG LQWHDCVRRQ
LGGFDTEART LSPSEPTVTR DEPESQALAG KLPAPKVKKP GRKPPTPGPE KAEAATGEGS
RNPSPSSGAS TSPPGPTLRA RFRNLLENAW LNGVALPTWG HKASGADRSS PHPQLLGSQT
HHL
