CO061_HUMAN
ID CO061_HUMAN Reviewed; 157 AA.
AC A6NNL5; B4DFB2;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Uncharacterized protein C15orf61;
DE Flags: Precursor;
GN Name=C15orf61;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AK294012; BAG57373.1; -; mRNA.
DR EMBL; AC016355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471082; EAW77798.1; -; Genomic_DNA.
DR CCDS; CCDS45289.1; -.
DR RefSeq; NP_001137408.1; NM_001143936.1.
DR AlphaFoldDB; A6NNL5; -.
DR BioGRID; 126948; 4.
DR IntAct; A6NNL5; 3.
DR STRING; 9606.ENSP00000342254; -.
DR iPTMnet; A6NNL5; -.
DR PhosphoSitePlus; A6NNL5; -.
DR BioMuta; C15orf61; -.
DR EPD; A6NNL5; -.
DR jPOST; A6NNL5; -.
DR MassIVE; A6NNL5; -.
DR MaxQB; A6NNL5; -.
DR PaxDb; A6NNL5; -.
DR PeptideAtlas; A6NNL5; -.
DR PRIDE; A6NNL5; -.
DR ProteomicsDB; 1617; -.
DR ABCD; A6NNL5; 1 sequenced antibody.
DR Antibodypedia; 77230; 4 antibodies from 4 providers.
DR DNASU; 145853; -.
DR Ensembl; ENST00000342683.6; ENSP00000342254.4; ENSG00000189227.6.
DR GeneID; 145853; -.
DR KEGG; hsa:145853; -.
DR MANE-Select; ENST00000342683.6; ENSP00000342254.4; NM_001143936.2; NP_001137408.1.
DR UCSC; uc002aqs.4; human.
DR CTD; 145853; -.
DR GeneCards; C15orf61; -.
DR HGNC; HGNC:34453; C15orf61.
DR HPA; ENSG00000189227; Tissue enhanced (skeletal).
DR neXtProt; NX_A6NNL5; -.
DR OpenTargets; ENSG00000189227; -.
DR PharmGKB; PA162378286; -.
DR VEuPathDB; HostDB:ENSG00000189227; -.
DR eggNOG; ENOG502S166; Eukaryota.
DR GeneTree; ENSGT00390000015942; -.
DR HOGENOM; CLU_129379_0_0_1; -.
DR InParanoid; A6NNL5; -.
DR OMA; GPITIYF; -.
DR OrthoDB; 1465932at2759; -.
DR PhylomeDB; A6NNL5; -.
DR TreeFam; TF332748; -.
DR PathwayCommons; A6NNL5; -.
DR SignaLink; A6NNL5; -.
DR BioGRID-ORCS; 145853; 11 hits in 1074 CRISPR screens.
DR GenomeRNAi; 145853; -.
DR Pharos; A6NNL5; Tdark.
DR PRO; PR:A6NNL5; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; A6NNL5; protein.
DR Bgee; ENSG00000189227; Expressed in secondary oocyte and 194 other tissues.
DR ExpressionAtlas; A6NNL5; baseline and differential.
DR Genevisible; A6NNL5; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR029245; DUF4528.
DR PANTHER; PTHR34651; PTHR34651; 1.
DR Pfam; PF15031; DUF4528; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..157
FT /note="Uncharacterized protein C15orf61"
FT /id="PRO_0000332740"
SQ SEQUENCE 157 AA; 18091 MW; 12E035D8F2FA5A90 CRC64;
MEALRRAHEV ALRLLLCRPW ASRAAARPKP SASEVLTRHL LQRRLPHWTS FCVPYSAVRN
DQFGLSHFNW PVQGANYHVL RTGCFPFIKY HCSKAPWQDL ARQNRFFTAL KVVNLGIPTL
LYGLGSWLFA RVTETVHTSY GPITVYFLNK EDEGAMY
