CO061_MOUSE
ID CO061_MOUSE Reviewed; 157 AA.
AC Q0VG49; Q3TYQ8;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-JAN-2010, sequence version 2.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Uncharacterized protein C15orf61 homolog;
DE Flags: Precursor;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Inner ear;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING
RP (ISOFORM 1).
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q0VG49-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q0VG49-2; Sequence=VSP_038577;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE34504.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK158428; BAE34504.1; ALT_FRAME; mRNA.
DR EMBL; CH466522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC116242; AAI16243.1; -; mRNA.
DR EMBL; BC116243; AAI16244.1; -; mRNA.
DR CCDS; CCDS52830.1; -. [Q0VG49-1]
DR RefSeq; NP_081366.1; NM_027090.1. [Q0VG49-1]
DR AlphaFoldDB; Q0VG49; -.
DR STRING; 10090.ENSMUSP00000127596; -.
DR PhosphoSitePlus; Q0VG49; -.
DR EPD; Q0VG49; -.
DR MaxQB; Q0VG49; -.
DR PaxDb; Q0VG49; -.
DR PeptideAtlas; Q0VG49; -.
DR PRIDE; Q0VG49; -.
DR Antibodypedia; 77230; 4 antibodies from 4 providers.
DR Ensembl; ENSMUST00000168665; ENSMUSP00000127596; ENSMUSG00000032403. [Q0VG49-1]
DR GeneID; 69478; -.
DR KEGG; mmu:69478; -.
DR UCSC; uc009qba.2; mouse. [Q0VG49-1]
DR UCSC; uc009qbb.1; mouse. [Q0VG49-2]
DR MGI; MGI:1916728; 2300009A05Rik.
DR VEuPathDB; HostDB:ENSMUSG00000032403; -.
DR eggNOG; ENOG502S166; Eukaryota.
DR GeneTree; ENSGT00390000015942; -.
DR HOGENOM; CLU_129379_0_0_1; -.
DR InParanoid; Q0VG49; -.
DR OMA; GPITIYF; -.
DR PhylomeDB; Q0VG49; -.
DR TreeFam; TF332748; -.
DR BioGRID-ORCS; 69478; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q0VG49; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q0VG49; protein.
DR Bgee; ENSMUSG00000032403; Expressed in right kidney and 154 other tissues.
DR Genevisible; Q0VG49; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR029245; DUF4528.
DR PANTHER; PTHR34651; PTHR34651; 1.
DR Pfam; PF15031; DUF4528; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..157
FT /note="Uncharacterized protein C15orf61 homolog"
FT /id="PRO_0000332741"
FT VAR_SEQ 117..157
FT /note="IPTLLYGLGSWLFARVTETVHTSYGPITIYFLNKEDEGAMY -> EWRRPRL
FT TQALLHPRAAAGPQARCSLSRAGPSHPRWAACSTPEVVPCHCPPGRTLPRAARSESRQW
FT LRSCLARVIPALITKSLWRTKNWTDF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_038577"
SQ SEQUENCE 157 AA; 17987 MW; 03C70F469188892C CRC64;
MEALRRAHEA TLRLLLCRPW ASGAASRPKP RASEVLTQHL LQRRLPHWTS FCVPYSAVHN
DQFGLSHFNW PVLGANYHVL RTGCFPFIKY HCSKAPWQDL APQDRFFTAL KVINLGIPTL
LYGLGSWLFA RVTETVHTSY GPITIYFLNK EDEGAMY
