CO062_HUMAN
ID CO062_HUMAN Reviewed; 175 AA.
AC A8K5M9; A6NK01;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Uncharacterized protein C15orf62, mitochondrial;
DE Flags: Precursor;
GN Name=C15orf62;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
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DR EMBL; AK291344; BAF84033.1; -; mRNA.
DR EMBL; AC012476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS45229.1; -.
DR RefSeq; NP_001123920.1; NM_001130448.2.
DR AlphaFoldDB; A8K5M9; -.
DR SMR; A8K5M9; -.
DR IntAct; A8K5M9; 2.
DR STRING; 9606.ENSP00000341178; -.
DR iPTMnet; A8K5M9; -.
DR PhosphoSitePlus; A8K5M9; -.
DR BioMuta; C15orf62; -.
DR jPOST; A8K5M9; -.
DR MassIVE; A8K5M9; -.
DR PaxDb; A8K5M9; -.
DR PeptideAtlas; A8K5M9; -.
DR PRIDE; A8K5M9; -.
DR ProteomicsDB; 1865; -.
DR Antibodypedia; 49844; 10 antibodies from 7 providers.
DR DNASU; 643338; -.
DR Ensembl; ENST00000344320.8; ENSP00000341178.6; ENSG00000188277.10.
DR GeneID; 643338; -.
DR KEGG; hsa:643338; -.
DR MANE-Select; ENST00000344320.8; ENSP00000341178.6; NM_001130448.3; NP_001123920.1.
DR UCSC; uc010bby.5; human.
DR CTD; 643338; -.
DR GeneCards; C15orf62; -.
DR HGNC; HGNC:34489; C15orf62.
DR HPA; ENSG00000188277; Tissue enhanced (esophagus, skin).
DR neXtProt; NX_A8K5M9; -.
DR OpenTargets; ENSG00000188277; -.
DR PharmGKB; PA162378296; -.
DR VEuPathDB; HostDB:ENSG00000188277; -.
DR eggNOG; ENOG502S89I; Eukaryota.
DR GeneTree; ENSGT00390000007057; -.
DR HOGENOM; CLU_1488562_0_0_1; -.
DR InParanoid; A8K5M9; -.
DR OMA; LNQNSHT; -.
DR OrthoDB; 1405648at2759; -.
DR PhylomeDB; A8K5M9; -.
DR TreeFam; TF336081; -.
DR PathwayCommons; A8K5M9; -.
DR BioGRID-ORCS; 643338; 10 hits in 1041 CRISPR screens.
DR ChiTaRS; C15orf62; human.
DR GenomeRNAi; 643338; -.
DR Pharos; A8K5M9; Tdark.
DR PRO; PR:A8K5M9; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; A8K5M9; protein.
DR Bgee; ENSG00000188277; Expressed in lower esophagus mucosa and 108 other tissues.
DR Genevisible; A8K5M9; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IBA:GO_Central.
DR GO; GO:0031274; P:positive regulation of pseudopodium assembly; IBA:GO_Central.
DR GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
PE 2: Evidence at transcript level;
KW Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..11
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 12..175
FT /note="Uncharacterized protein C15orf62, mitochondrial"
FT /id="PRO_0000332136"
FT REGION 24..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..67
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 175 AA; 19679 MW; 4CAA272143159661 CRC64;
METWRKGSFR NASFFKQLSL GRPRRLRRQS SVLSQASTAG GDHEEYSNRE VIRELQGRPD
GRRLPLWGDE QPRATLLAPP KPPRLYRESS SCPNILEPPP AYTAAYSATL PSALSLSSAL
HQHSEKGLVD TPCFQRTPTP DLSDPFLSFK VDLGISLLEE VLQMLREQFP SEPSF
