ID   CO112_CONCL             Reviewed;          65 AA.
AC   D5KR59;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Conotoxin Cal1.2 {ECO:0000303|PubMed:21172372};
DE   Flags: Precursor;
OS   Californiconus californicus (California cone) (Conus californicus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX   NCBI_TaxID=1736779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=21172372; DOI=10.1016/j.toxicon.2010.12.008;
RA   Elliger C.A., Richmond T.A., Lebaric Z.N., Pierce N.T., Sweedler J.V.,
RA   Gilly W.F.;
RT   "Diversity of conotoxin types from Conus californicus reflects a diversity
RT   of prey types and a novel evolutionary history.";
RL   Toxicon 57:311-322(2011).
CC   -!- FUNCTION: Probable neurotoxin with unknown target. Possibly targets ion
CC       channels. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:21172372}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:21172372}.
CC   -!- DOMAIN: The cysteine framework is I (CC-C-C). Alpha9/4 pattern.
CC       {ECO:0000305}.
CC   -!- PTM: Contains 2 disulfide bonds. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   EMBL; GU591495; ADD97803.1; -; mRNA.
DR   AlphaFoldDB; D5KR59; -.
DR   ConoServer; 4058; Cal1.2 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..65
FT                   /evidence="ECO:0000305|PubMed:21172372"
FT                   /id="PRO_5000585096"
FT   PEPTIDE         46..64
FT                   /note="Conotoxin Cal1.2"
FT                   /evidence="ECO:0000305|PubMed:21172372"
FT                   /id="PRO_5000585097"
SQ   SEQUENCE   65 AA;  7488 MW;  21188CA5CED6D464 CRC64;
     MKLTCVFIIA VLILTACHFI VADDTGDREW RDLEWLRSLK AHDKRAGCCP TIMYKTGACR
     TNRCR