CO1A1_MACSX
ID CO1A1_MACSX Reviewed; 958 AA.
AC C0HJP5;
DT 22-JUL-2015, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2015, sequence version 1.
DT 03-AUG-2022, entry version 15.
DE RecName: Full=Collagen alpha-1(I) chain {ECO:0000303|PubMed:25799987};
DE AltName: Full=Alpha-1 type I collagen {ECO:0000250|UniProtKB:P02452};
DE Flags: Fragments;
GN Name=COL1A1 {ECO:0000250|UniProtKB:P02452};
OS Macrauchenia sp.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Litopterna; Macraucheniidae; Macrauchenia;
OC unclassified Macrauchenia.
OX NCBI_TaxID=1563127 {ECO:0000303|PubMed:25799987};
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Bone {ECO:0000303|PubMed:25799987};
RX PubMed=25799987; DOI=10.1038/nature14249;
RA Welker F., Collins M.J., Thomas J.A., Wadsley M., Brace S., Cappellini E.,
RA Turvey S.T., Reguero M., Gelfo J.N., Kramarz A., Burger J.,
RA Thomas-Oates J., Ashford D.A., Ashton P.D., Rowsell K., Porter D.M.,
RA Kessler B., Fischer R., Baessmann C., Kaspar S., Olsen J.V., Kiley P.,
RA Elliott J.A., Kelstrup C.D., Mullin V., Hofreiter M., Willerslev E.,
RA Hublin J.J., Orlando L., Barnes I., MacPhee R.D.;
RT "Ancient proteins resolve the evolutionary history of Darwin's South
RT American ungulates.";
RL Nature 522:81-84(2015).
CC -!- FUNCTION: Type I collagen is a member of group I collagen (fibrillar
CC forming collagen). {ECO:0000305}.
CC -!- SUBUNIT: Trimers of one alpha 2(I) and two alpha 1(I) chains.
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted. Secreted, extracellular space.
CC Secreted, extracellular space, extracellular matrix {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Forms the fibrils of tendon, ligaments and bones.
CC In bones, the fibrils are mineralized with calcium hydroxyapatite.
CC {ECO:0000305}.
CC -!- PTM: Prolines at the third position of the tripeptide repeating unit
CC (G-X-Y) are hydroxylated in some or all of the chains. {ECO:0000305}.
CC -!- MISCELLANEOUS: These protein fragments were extracted from fossils. The
CC tryptic peptides required multiple purification steps in order to
CC eliminate contaminants and to increase the concentration of peptidic
CC material. {ECO:0000305|PubMed:25799987}.
CC -!- SIMILARITY: Belongs to the fibrillar collagen family. {ECO:0000305}.
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DR AlphaFoldDB; C0HJP5; -.
DR PRIDE; C0HJP5; -.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR InterPro; IPR008160; Collagen.
DR Pfam; PF01391; Collagen; 12.
PE 1: Evidence at protein level;
KW Calcium; Collagen; Direct protein sequencing; Extinct organism protein;
KW Extracellular matrix; Hydroxylation; Phosphoprotein; Repeat; Secreted.
FT CHAIN 1..958
FT /note="Collagen alpha-1(I) chain"
FT /evidence="ECO:0000269|PubMed:25799987"
FT /id="PRO_0000433495"
FT REGION 1..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..47
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..247
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..381
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..675
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..958
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 92
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02454"
FT MOD_RES 560
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02454"
FT UNSURE 11
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 76
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 82
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 94
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 127
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 219
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 289
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 343
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 349
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 454
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 474
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 511
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 538
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 542
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 626
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 727
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 736
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 748
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 778
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 844
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 873
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 882
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 921
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 924
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 928
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT NON_CONS 23..24
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 211..212
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 256..257
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 469..470
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 506..507
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 799..800
FT /evidence="ECO:0000303|PubMed:25799987"
SQ SEQUENCE 958 AA; 85096 MW; 27B8C28E26527880 CRC64;
GPMGPSGPRG IPGPPGAPGP QGFGPPGEPG EPGASGPMGP RGPPGPPGKN GDDGEAGKPG
RPGERGPPGP QGARGIPGTA GIPGMKGHRG FSGIDGAKGD AGPAGPKGEP GSPGENGAPG
QMGPRGIPGE RGRPGAPGPA GARGNDGATG AAGPPGPTGP AGPPGFPGAV GAKGEAGPQG
ARGSEGPQGV RGEPGPPGPA GAAGPAGNPG AGANGAPGIA GAPGFPGARG PSGPQGPSGP
PGPKGNSGEP GAPGSKKGEP GPTGVQGPPG PAGEEGKRGA RGEPGPTGIP GPPGERGGPG
SRGFPGSDGV AGPKGPAGER GAPGPAGPKG SPGEAGRPGE AGIPGAKGIT GSPGSPGPDG
KTGPPGPAGQ DGRPGPPGPP GARGQAGVMG FPGPKGAAGE PGKAGERGVP GPPGAVGPAG
KDGEAGAQGP PGPAGPAGER GEPGPAGSPG FQGIPGPAGP PGESGKPGEV PGDIGAPGPS
GARGERGFPG ERGVQGPPGP AGPRGAGAAG IPGPKGDRGD AGPKGADGAP GKDGVRGITG
PIGPPGPAGA PGDKGESGPS GPAGPTGARG APGDRGEPGP PGPAGFAGPP GADGQPGAKG
EPGDAGAKGD AGPAGPAGPT GPPGPIGNVG APGPKGARGS AGPPGATGFP GAAGRVGPPG
PAGNAGPPGP PGPVGKEGGK GPRGETGPAG RPGEVGPPGP PGPAGEKGSP GADGPAGAPG
TPGPQGIAGQ RGVVGIPGQR GERGFPGIPG PSGEPGKQGP SGASGERGPP GPVGPPGIAG
PPGESGREGA PGAEGSPGRG DRGETGPAGP PGAPGAPGAP GPVGPAGKSG DRGETGPAGP
AGPIGPVGAR GPTGPQGPRG DKGETGEQGD RGIKGHRGFS GIQGPTGPPG APGEQGPSGA
SGPAGPRGPP GSAGAPGKDG INGIPGPIGP PGPRGRTGDA GPVGPPGPPG PPGPPGPP
