CO1A1_MAMAE
ID CO1A1_MAMAE Reviewed; 1057 AA.
AC P0C2W8;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-FEB-2012, sequence version 4.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=Collagen alpha-1(I) chain;
DE AltName: Full=Alpha-1 type I collagen;
GN Name=COL1A1;
OS Mammut americanum (American mastodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Mammut.
OX NCBI_TaxID=39053;
RN [1]
RP PROTEIN SEQUENCE.
RC TISSUE=Bone;
RX PubMed=22021854; DOI=10.1126/science.1207663;
RA Waters M.R., Stafford T.W. Jr., McDonald H.G., Gustafson C., Rasmussen M.,
RA Cappellini E., Olsen J.V., Szklarczyk D., Jensen L.J., Gilbert M.T.,
RA Willerslev E.;
RT "Pre-Clovis mastodon hunting 13,800 years ago at the Manis site,
RT Washington.";
RL Science 334:351-353(2011).
RN [2]
RP PROTEIN SEQUENCE OF 60-85; 88-98; 108-142; 161-307; 311-325; 332-433;
RP 438-467; 522-536; 549-662; 672-701; 705-721; 747-774; 798-805; 809-832;
RP 853-946; 951-1007 AND 1010-1031.
RC TISSUE=Bone;
RX PubMed=18436782; DOI=10.1126/science.1154284;
RA Organ C.L., Schweitzer M.H., Zheng W., Freimark L.M., Cantley L.C.,
RA Asara J.M.;
RT "Molecular phylogenetics of mastodon and Tyrannosaurus rex.";
RL Science 320:499-499(2008).
RN [3]
RP PROTEIN SEQUENCE OF 108-116; 126-143; 150-191; 201-269; 282-308; 312-326;
RP 333-391; 414-425; 525-536; 603-635; 705-742; 750-773; 810-823; 854-872;
RP 876-932; 951-980 AND 992-1007, IDENTIFICATION BY MASS SPECTROMETRY, AND
RP HYDROXYLATION AT PRO-128; PRO-131; PRO-173; PRO-182; PRO-185; PRO-212;
RP PRO-215; PRO-227; PRO-242; PRO-248; PRO-251; PRO-266; PRO-290; PRO-292;
RP PRO-299; PRO-314; PRO-320; PRO-323; PRO-335; PRO-362; PRO-368; PRO-374;
RP PRO-383; PRO-386; PRO-422; PRO-530; PRO-611; PRO-617; PRO-710; PRO-716;
RP PRO-758; PRO-764; PRO-767; PRO-812; PRO-815; PRO-863; PRO-869; PRO-887;
RP PRO-890; PRO-959; PRO-962; PRO-965; PRO-998; PRO-1001 AND PRO-1004.
RC TISSUE=Bone;
RA Asara J.M.;
RL Submitted (SEP-2007) to UniProtKB.
RN [4]
RP PROTEIN SEQUENCE OF 201-209; 255-269; 603-635 AND 854-872, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Bone;
RX PubMed=17431180; DOI=10.1126/science.1137614;
RA Asara J.M., Schweitzer M.H., Freimark L.M., Phillips M., Cantley L.C.;
RT "Protein sequences from Mastodon and Tyrannosaurus rex revealed by mass
RT spectrometry.";
RL Science 316:280-285(2007).
RN [5]
RP COMMENTS ON INTERPRETATION OF POTENTIAL HYDROXYLATION SITES.
RX PubMed=17823333; DOI=10.1126/science.317.5843.1324;
RA Asara J.M., Garavelli J.S., Slatter D.A., Schweitzer M.H., Freimark L.M.,
RA Phillips M., Cantley L.C.;
RT "Interpreting sequences from mastodon and T. rex.";
RL Science 317:1324-1325(2007).
CC -!- FUNCTION: Type I collagen is a member of group I collagen (fibrillar
CC forming collagen).
CC -!- SUBUNIT: Trimers of one alpha 2(I) and two alpha 1(I) chains.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250}.
CC -!- PTM: Contains mostly 4-hydroxyproline. Proline residues at the third
CC position of the tripeptide repeating unit (G-X-Y) are hydroxylated in
CC some or all of the chains. {ECO:0000269|Ref.3}.
CC -!- PTM: Contains 3-hydroxyproline at a few sites. This modification occurs
CC on the first proline residue in the sequence motif Gly-Pro-Hyp, where
CC Hyp is 4-hydroxyproline. {ECO:0000250|UniProtKB:P11087}.
CC -!- PTM: Lysine residues at the third position of the tripeptide repeating
CC unit (G-X-Y) are 5-hydroxylated in some or all of the chains.
CC {ECO:0000250|UniProtKB:P02457}.
CC -!- PTM: O-glycosylated on hydroxylated lysine residues. The O-linked
CC glycan consists of a Glc-Gal disaccharide.
CC {ECO:0000250|UniProtKB:P11087}.
CC -!- MISCELLANEOUS: This protein sequence was reconstructed from 13,800 and
CC 160,000 to 600,000 year old bones. The tryptic peptides required
CC multiple purification steps in order to eliminate contaminants and to
CC increase the concentration of peptidic material.
CC -!- SIMILARITY: Belongs to the fibrillar collagen family. {ECO:0000305}.
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DR AlphaFoldDB; P0C2W8; -.
DR PRIDE; P0C2W8; -.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR InterPro; IPR008160; Collagen.
DR Pfam; PF01391; Collagen; 9.
PE 1: Evidence at protein level;
KW Collagen; Direct protein sequencing; Extinct organism protein;
KW Extracellular matrix; Glycoprotein; Hydroxylation; Phosphoprotein;
KW Pyrrolidone carboxylic acid; Repeat; Secreted.
FT CHAIN 1..1057
FT /note="Collagen alpha-1(I) chain"
FT /id="PRO_0000287477"
FT DOMAIN 18..76
FT /note="Collagen-like 1"
FT DOMAIN 75..134
FT /note="Collagen-like 2"
FT DOMAIN 135..193
FT /note="Collagen-like 3"
FT DOMAIN 195..252
FT /note="Collagen-like 4"
FT DOMAIN 522..579
FT /note="Collagen-like 5"
FT DOMAIN 555..613
FT /note="Collagen-like 6"
FT DOMAIN 618..676
FT /note="Collagen-like 7"
FT DOMAIN 678..736
FT /note="Collagen-like 8"
FT DOMAIN 804..861
FT /note="Collagen-like 9"
FT DOMAIN 918..976
FT /note="Collagen-like 10"
FT DOMAIN 972..1030
FT /note="Collagen-like 11"
FT REGION 1..1057
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1..17
FT /note="Nonhelical region (N-terminal)"
FT REGION 18..1031
FT /note="Triple-helical region"
FT REGION 1032..1055
FT /note="Nonhelical region (C-terminal)"
FT COMPBIAS 22..65
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..411
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..741
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1015..1034
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P02453"
FT MOD_RES 9
FT /note="Allysine"
FT /evidence="ECO:0000250|UniProtKB:P02452"
FT MOD_RES 10
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02454"
FT MOD_RES 29
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 32
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 35
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 44
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 47
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 50
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 65
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 80
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 86
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 95
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 101
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 104
FT /note="5-hydroxylysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 110
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02454"
FT MOD_RES 128
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 131
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 137
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 146
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 152
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 173
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 182
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 185
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 212
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 215
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 227
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 233
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 242
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 248
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 251
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 266
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 269
FT /note="5-hydroxylysine"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 275
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 278
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 290
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 292
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 299
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 314
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 320
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 323
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 329
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 335
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 344
FT /note="5-hydroxylysine"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 353
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 362
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 368
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 374
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 383
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 386
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 395
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 404
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 410
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 422
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 431
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 440
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 443
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 461
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 479
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 485
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 491
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 497
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 503
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 509
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 521
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 530
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 542
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 554
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 557
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 563
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 569
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 578
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 590
FT /note="5-hydroxylysine"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 596
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 611
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 617
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 626
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02454"
FT MOD_RES 638
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 644
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 647
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 656
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 662
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 680
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 689
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 698
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 701
FT /note="5-hydroxylysine"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 710
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 716
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 724
FT /note="3-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 725
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 734
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 737
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 758
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 764
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 767
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 776
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 785
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 803
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 812
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 815
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 821
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 836
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 842
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 848
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 857
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 863
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 869
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 872
FT /note="5-hydroxylysine"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 884
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 887
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 890
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 935
FT /note="5-hydroxylysine"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 947
FT /note="5-hydroxylysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 959
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 962
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 965
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 983
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 998
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 1001
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 1003
FT /note="3-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 1004
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|Ref.3"
FT MOD_RES 1018
FT /note="3-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 1019
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 1021
FT /note="3-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 1022
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 1024
FT /note="3-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 1025
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 1028
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 1031
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 1047
FT /note="Allysine"
FT /evidence="ECO:0000250|UniProtKB:P02452"
FT CARBOHYD 104
FT /note="O-linked (Gal...) hydroxylysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT CARBOHYD 947
FT /note="O-linked (Gal...) hydroxylysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT UNSURE 2
FT /note="L or I"
FT UNSURE 14
FT /note="I or L"
FT UNSURE 28
FT /note="L or I"
FT UNSURE 94
FT /note="L or I"
FT UNSURE 100
FT /note="L or I"
FT UNSURE 112
FT /note="L or I"
FT UNSURE 136
FT /note="A or S"
FT UNSURE 145
FT /note="L or I"
FT UNSURE 152
FT /note="P or I"
FT UNSURE 232
FT /note="Q or E"
FT UNSURE 244
FT /note="I or L"
FT UNSURE 265
FT /note="A or S"
FT UNSURE 286
FT /note="A or S"
FT UNSURE 293
FT /note="I or L"
FT UNSURE 295
FT /note="I or L"
FT UNSURE 302
FT /note="A or S"
FT UNSURE 319
FT /note="L or I"
FT UNSURE 323
FT /note="P or L"
FT UNSURE 373
FT /note="L or I"
FT UNSURE 379
FT /note="L or I"
FT UNSURE 484
FT /note="L or I"
FT UNSURE 506
FT /note="L or I"
FT UNSURE 565
FT /note="L or I"
FT UNSURE 577
FT /note="L or I"
FT UNSURE 604
FT /note="L or I"
FT UNSURE 608
FT /note="I or L"
FT UNSURE 614
FT /note="A or S"
FT UNSURE 623
FT /note="A or G"
FT UNSURE 626
FT /note="S or P"
FT UNSURE 629
FT /note="A or S"
FT UNSURE 692
FT /note="I or L"
FT UNSURE 793
FT /note="I or L"
FT UNSURE 802
FT /note="L or I"
FT UNSURE 814
FT /note="L or I"
FT UNSURE 844
FT /note="L or I"
FT UNSURE 889
FT /note="A or S"
FT UNSURE 929
FT /note="Q or P"
FT UNSURE 946
FT /note="L or I"
FT UNSURE 953
FT /note="S or T"
FT UNSURE 955
FT /note="L or I"
FT UNSURE 994
FT /note="L or I"
FT UNSURE 997
FT /note="L or I"
FT UNSURE 1001
FT /note="P or I"
FT UNSURE 1040
FT /note="L or I"
FT CONFLICT 208
FT /note="V -> T (in Ref. 4; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 257
FT /note="A -> S (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 278..280
FT /note="PGS -> QGN (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 284
FT /note="A -> T (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 293
FT /note="I -> V (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 407
FT /note="P -> A (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 427
FT /note="A -> T (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 448
FT /note="A -> P (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 551
FT /note="A -> T (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 698..700
FT /note="PGA -> SGP (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 871
FT /note="P -> A (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 881
FT /note="S -> A (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1057 AA; 94612 MW; 0C31C0FE0CC5783F CRC64;
QLSYGYDEKS AGGISVPGPM GPSGPRGLPG PPGAPGPQGF QGPPGEPGEP GASGPMGPRG
PPGPPGKNGD DGEAGKPGRP GERGPPGPQG ARGLPGTAGL PGMKGHRGFS GLDGAKGDAG
PAGPKGEPGS PGENGAPGQM GPRGLPGERG RPGAPGPAGA RGNDGATGAA GPPGPTGPAG
PPGFPGAVGA KGEAGPQGAR GSEGPQGVRG EPGPPGPAGA AGPAGNPGAD GQPGAKGANG
APGIAGAPGF PGARGPAGPQ GPSGAPGPKG NSGEPGAPGS KGDAGAKGEP GPIGIQGPPG
PAGEEGKRGA RGEPGPTGLP GPPGERGGPG SRGFPGADGV AGPKGPAGER GSPGPAGPKG
SPGEAGRPGE AGLPGAKGLT GSPGSPGPDG KTGPPGPAGQ DGRPGPPGPP GARGQAGVMG
FPGPKGAAGE PGKAGERGVP GPPGAVGAAG KDGEAGAQGP PGPAGPAGER GEQGPAGSPG
FQGLPGPAGP PGEAGKPGEQ GVPGDLGAPG PSGARGERGF PGERGVQGPP GPAGPRGSNG
APGNDGAKGD AGAPGAPGSQ GAPGLQGMPG ERGAAGLPGP KGDRGDAGPK GADGSPGKDG
PRGLTGPIGP PGPAGAPGDK GEAGPSGPAG PTGARGAPGD RGEPGPPGPA GFAGPPGADG
QPGAKGEPGD AGAKGDAGPP GPAGPTGAPG PIGNVGAPGA KGARGSAGPP GATGFPGAAG
RVGPPGPSGN AGPPGPPGPA GKEGGKGPRG ETGPAGRPGE VGPPGPPGPA GEKGSPGADG
PAGAPGTPGP QGIGGQRGVV GLPGQRGERG FPGLPGPSGE PGKQGPSGSS GERGPPGPAG
PPGLAGPPGE SGREGAPGAE GSPGRDGSPG PKGDRGETGP SGPPGAPGAP GAPGPVGPAG
KSGDRGETGP AGPAGPAGPA GVRGPAGPQG PRGDKGETGE QGDRGLKGHR GFSGLQGPPG
PPGSPGEQGP SGASGPAGPR GPPGSAGAPG KDGLNGLPGP PGPPGPRGRT GDAGPVGPPG
PPGPPGPPGP PSGAFDFSFL PQPPQEKAHD GGRYYRA
