CO1A1_MEGAE
ID CO1A1_MEGAE Reviewed; 1014 AA.
AC C0HLJ5;
DT 13-NOV-2019, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2019, sequence version 1.
DT 25-MAY-2022, entry version 5.
DE RecName: Full=Collagen alpha-1(I) chain {ECO:0000303|PubMed:31171860};
DE AltName: Full=Alpha-1 type I collagen {ECO:0000250|UniProtKB:P02452};
DE Flags: Fragments;
OS Megatherium americanum (Giant ground sloth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Xenarthra; Pilosa; Folivora; Megatheriidae; Megatherium.
OX NCBI_TaxID=2546660 {ECO:0000303|PubMed:31171860};
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, TISSUE SPECIFICITY, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC TISSUE=Bone {ECO:0000303|PubMed:31171860};
RX PubMed=31171860; DOI=10.1038/s41559-019-0909-z;
RA Presslee S., Slater G.J., Pujos F., Forasiepi A.M., Fischer R., Molloy K.,
RA Mackie M., Olsen J.V., Kramarz A., Taglioretti M., Scaglia F., Lezcano M.,
RA Lanata J.L., Southon J., Feranec R., Bloch J., Hajduk A., Martin F.M.,
RA Salas Gismondi R., Reguero M., de Muizon C., Greenwood A., Chait B.T.,
RA Penkman K., Collins M., MacPhee R.D.E.;
RT "Palaeoproteomics resolves sloth relationships.";
RL Nat. Ecol. Evol. 3:1121-1130(2019).
CC -!- FUNCTION: Type I collagen is a member of group I collagen (fibrillar
CC forming collagen). {ECO:0000305}.
CC -!- SUBUNIT: Trimers of one alpha 2(I) and two alpha 1(I) chains.
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted. Secreted, extracellular space.
CC Secreted, extracellular space, extracellular matrix {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in bones. {ECO:0000269|PubMed:31171860}.
CC -!- PTM: Contains mostly 4-hydroxyproline. Proline residues at the third
CC position of the tripeptide repeating unit (G-X-Y) are hydroxylated in
CC some or all of the chains. {ECO:0000250|UniProtKB:P02452}.
CC -!- PTM: Contains 3-hydroxyproline at a few sites. This modification occurs
CC on the first proline residue in the sequence motif Gly-Pro-Hyp, where
CC Hyp is 4-hydroxyproline. {ECO:0000250|UniProtKB:P11087}.
CC -!- PTM: Lysine residues at the third position of the tripeptide repeating
CC unit (G-X-Y) are 5-hydroxylated in some or all of the chains.
CC {ECO:0000250|UniProtKB:P02452}.
CC -!- PTM: O-glycosylated on hydroxylated lysine residues. The O-linked
CC glycan consists of a Glc-Gal disaccharide.
CC {ECO:0000250|UniProtKB:P02452}.
CC -!- MISCELLANEOUS: These protein fragments were extracted from an ancient
CC rib bone collected at Bariloche in Argentina and estimated to be around
CC 19050 years old. {ECO:0000269|PubMed:31171860}.
CC -!- SIMILARITY: Belongs to the fibrillar collagen family. {ECO:0000305}.
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DR AlphaFoldDB; C0HLJ5; -.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR InterPro; IPR008160; Collagen.
DR Pfam; PF01391; Collagen; 7.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Extinct organism protein; Extracellular matrix;
KW Glycoprotein; Hydroxylation; Phosphoprotein; Secreted.
FT CHAIN 1..1014
FT /note="Collagen alpha-1(I) chain"
FT /id="PRO_0000448468"
FT REGION 1..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..60
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..267
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..406
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..726
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 744..758
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1014
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 25
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 28
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 30
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 39
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 42
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 45
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 60
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 75
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 81
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 90
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 96
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 99
FT /note="5-hydroxylysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P02452"
FT MOD_RES 105
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02454"
FT MOD_RES 123
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 126
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 132
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 141
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 147
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 168
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 177
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 180
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 207
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 210
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 222
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 228
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 237
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 243
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 246
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 261
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 264
FT /note="5-hydroxylysine"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 270
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 273
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 285
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 294
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 309
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 315
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 324
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 330
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 339
FT /note="5-hydroxylysine"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 348
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 357
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 363
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 369
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 378
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 381
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 390
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 399
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 405
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 417
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 426
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 435
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 438
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 456
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 473
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 479
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 485
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 491
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 497
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 503
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 515
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 524
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 535
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 548
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 554
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 563
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 575
FT /note="5-hydroxylysine"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 581
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 596
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 602
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 611
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02454"
FT MOD_RES 623
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 629
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 632
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 641
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 647
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 674
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 683
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 686
FT /note="5-hydroxylysine"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 695
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 701
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 709
FT /note="3-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 710
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 719
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 722
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 743
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 752
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 760
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 769
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 787
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 796
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 799
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 805
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 820
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 826
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 832
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 841
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 847
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 856
FT /note="5-hydroxylysine"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 867
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 870
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 873
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 918
FT /note="5-hydroxylysine"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 930
FT /note="5-hydroxylysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 945
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 948
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 966
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT MOD_RES 981
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 986
FT /note="3-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 987
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 1001
FT /note="3-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 1002
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 1004
FT /note="3-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 1005
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 1007
FT /note="3-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 1008
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 1011
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT MOD_RES 1014
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P11087"
FT CARBOHYD 99
FT /note="O-linked (Gal...) hydroxylysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P02452"
FT CARBOHYD 930
FT /note="O-linked (Gal...) hydroxylysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P02457"
FT UNSURE 10
FT /note="I or L"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 24
FT /note="L or I"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 89
FT /note="L or I"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 95
FT /note="L or I"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 107
FT /note="L or I"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 140
FT /note="L or I"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 239
FT /note="I or L"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 290
FT /note="I or L"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 314
FT /note="L or I"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 368
FT /note="L or I"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 374
FT /note="L or I"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 478
FT /note="L or I"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 500
FT /note="L or I"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 550
FT /note="L or I"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 562
FT /note="L or I"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 589
FT /note="L or I"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 593
FT /note="I or L"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 677
FT /note="I or L"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 777
FT /note="I or L"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 786
FT /note="L or I"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 798
FT /note="L or I"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 828
FT /note="L or I"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 929
FT /note="I or L"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 938
FT /note="L or I"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 977
FT /note="L or I"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 980
FT /note="L or I"
FT /evidence="ECO:0000303|PubMed:31171860"
FT UNSURE 984
FT /note="I or L"
FT /evidence="ECO:0000303|PubMed:31171860"
FT NON_CONS 7..8
FT /evidence="ECO:0000303|PubMed:31171860"
FT NON_CONS 29..30
FT /evidence="ECO:0000303|PubMed:31171860"
FT NON_CONS 472..473
FT /evidence="ECO:0000303|PubMed:31171860"
FT NON_CONS 543..544
FT /evidence="ECO:0000303|PubMed:31171860"
FT NON_CONS 754..755
FT /evidence="ECO:0000303|PubMed:31171860"
FT NON_CONS 864..865
FT /evidence="ECO:0000303|PubMed:31171860"
FT NON_TER 1
FT /evidence="ECO:0000303|PubMed:31171860"
FT NON_TER 1014
FT /evidence="ECO:0000303|PubMed:31171860"
SQ SEQUENCE 1014 AA; 90533 MW; 9CCCEB39E2A9F90B CRC64;
SYGYDEKGGI SVPGPMGPSG PRGLPGPPGP GPQGFQGPPG EPGEPGSSGP MGPRGPPGPP
GKNGDDGEAG KPGRPGERGP PGPQGARGLP GTAGLPGMKG HRGFSGLDGA KGDAGPAGPK
GEPGSPGENG APGQMGPRGL PGERGRPGAS GPAGARGNDG ATGAAGPPGP TGPAGPPGFP
GAVGAKGEAG PQGARGSEGP QGVRGEPGPP GPAGAAGPAG NPGADGQPGA KGANGAPGIA
GAPGFPGARG PSGPQGPSGP PGPKGNSGEP GAPGSKGDTG AKGEPGPTGI QGPPGPAGEE
GKRGARGEPG PTGLPGPPGE RGGPGSRGFP GADGVAGPKG PAGERGSPGP AGPKGSPGEA
GRPGEAGLPG AKGLTGSPGS PGPDGKTGPP GPAGQDGRPG PPGPPGARGQ AGVMGFPGPK
GAAGEPGKAG ERGVPGPPGA VGPAGKDGEA GAQGPPGPAG PAGERGEQGP AGPGFQGLPG
PAGPPGEAGK PGEQGVPGDL GAPGPSGARG ERGFPGERGV QGPPGPAGPR GNGAPGNDGA
KGDSQGAPGL QGMPGERGAA GLPGPKGDRG DAGPKGADGA PGKDGVRGLT GPIGPPGPAG
APGDKGESGP SGPAGPTGAR GAPGDRGEPG PPGPAGFAGP PGADGQPGAK GEPGDAGAKG
DAGPSGPAGP TGPPGPIGNV GAPGPKGARG SAGPPGATGF PGAAGRVGPP GPSGNAGPPG
PPGPVGKEGG KGPRGETGPA GRPGEVGPPG PPGPGEKGSP GADGPAGAPG TPGPQGISGQ
RGVVGLPGQR GERGFPGLPG PSGEPGKQGP SGSSGERGPP GPVGPPGLAG PPGESGREGA
PGAEGSPGRD GSPGPKGDRG ETGPGPPGAP GAPGAPGPVG PAGKNGDRGE TGPAGPAGPA
GPAGARGPAG PQGPRGDKGE TGEQGDRGIK GHRGFSGLQG PAGPPGSPGE QGPSGASGPA
GPRGPPGSAG SPGKDGLNGL PGPIGPPGPR GRTGDAGPVG PPGPPGPPGP PGPP
