CO1A1_ORYAF
ID CO1A1_ORYAF Reviewed; 987 AA.
AC C0HJN3;
DT 22-JUL-2015, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2015, sequence version 1.
DT 03-AUG-2022, entry version 14.
DE RecName: Full=Collagen alpha-1(I) chain {ECO:0000303|PubMed:25799987};
DE AltName: Full=Alpha-1 type I collagen {ECO:0000250|UniProtKB:P02452};
DE Flags: Fragments;
GN Name=COL1A1 {ECO:0000250|UniProtKB:P02452};
OS Orycteropus afer (Aardvark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Tubulidentata; Orycteropodidae; Orycteropus.
OX NCBI_TaxID=9818 {ECO:0000303|PubMed:25799987};
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Bone {ECO:0000303|PubMed:25799987};
RX PubMed=25799987; DOI=10.1038/nature14249;
RA Welker F., Collins M.J., Thomas J.A., Wadsley M., Brace S., Cappellini E.,
RA Turvey S.T., Reguero M., Gelfo J.N., Kramarz A., Burger J.,
RA Thomas-Oates J., Ashford D.A., Ashton P.D., Rowsell K., Porter D.M.,
RA Kessler B., Fischer R., Baessmann C., Kaspar S., Olsen J.V., Kiley P.,
RA Elliott J.A., Kelstrup C.D., Mullin V., Hofreiter M., Willerslev E.,
RA Hublin J.J., Orlando L., Barnes I., MacPhee R.D.;
RT "Ancient proteins resolve the evolutionary history of Darwin's South
RT American ungulates.";
RL Nature 522:81-84(2015).
CC -!- FUNCTION: Type I collagen is a member of group I collagen (fibrillar
CC forming collagen). {ECO:0000305}.
CC -!- SUBUNIT: Trimers of one alpha 2(I) and two alpha 1(I) chains.
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted. Secreted, extracellular space.
CC Secreted, extracellular space, extracellular matrix {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Forms the fibrils of tendon, ligaments and bones.
CC In bones, the fibrils are mineralized with calcium hydroxyapatite.
CC {ECO:0000305}.
CC -!- PTM: Prolines at the third position of the tripeptide repeating unit
CC (G-X-Y) are hydroxylated in some or all of the chains. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the fibrillar collagen family. {ECO:0000305}.
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DR AlphaFoldDB; C0HJN3; -.
DR PRIDE; C0HJN3; -.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR InterPro; IPR008160; Collagen.
DR Pfam; PF01391; Collagen; 8.
PE 1: Evidence at protein level;
KW Calcium; Collagen; Direct protein sequencing; Extracellular matrix;
KW Hydroxylation; Phosphoprotein; Repeat; Secreted.
FT CHAIN 1..987
FT /note="Collagen alpha-1(I) chain"
FT /evidence="ECO:0000269|PubMed:25799987"
FT /id="PRO_0000433497"
FT REGION 1..987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..48
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..388
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..715
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 795..809
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 957..987
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 93
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02454"
FT UNSURE 11
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 77
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 83
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 95
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 128
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 227
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 278
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 302
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 350
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 356
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 461
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 479
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 483
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 542
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 554
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 581
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 585
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 669
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 728
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 760
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 769
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 778
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 808
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 881
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 913
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 952
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 955
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 959
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT NON_CONS 309..310
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 678..679
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 716..717
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 773..774
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 908..909
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 965..966
FT /evidence="ECO:0000303|PubMed:25799987"
SQ SEQUENCE 987 AA; 87663 MW; 4704BDAB87565386 CRC64;
GPMGPSGPRG IPGPPGAPGP QGFQGPPGEP GEPGASGPMG PRGPPGPPGK NGDDGEAGKP
GRPGERGPPG PQGARGIPGT AGIPGMKGHR GFSGIDGAKG DAGPAGPKGE PGSPGENGAP
GQMGPRGIPG ERGRPGPPGP AGARGNDGAT GAAGPPGPTG PAGPPGFPGA VGAKGEAGPQ
GPRGSEGPQG VRGEPGPPGP AGAAGPAGNP GADGQPGAKG ANGAPGIAGA PGFPGARGPS
GPQGPSGAPG PKGNSGEPGA PGNKGDAGAK GEPGPAGIQG PPGPAGEEGK RGARGEPGPT
GIPGPPGERG FPGSDGVAGP KGPVGERGSP GPAGPKGSPG EAGRPGEAGI PGAKGITGSP
GSPGPDGKTG PPGPAGQDGR PGPPGPPGAR GQAGVMGFPG PKGAAGEPGK AGERGVPGPP
GAVGAPGKDG EAGAPGATGP AGPAGERGEQ GPAGSPGFQG IPGPAGPPGE SGKPGEQGIP
GDIGAPGPSG ARGERGFPGE RGVQGPPGPA GPRGSNGAPG NDGAKGDAGA PGAPGSQGAP
GIQGMPGERG AAGIPGPKGD RGDAGPKGAD GSPGKDGPRG ITGPIGPPGP AGAPGDKGES
GPNGPAGPTG ARGAPGDRGE PGPPGPAGFA GPPGADGQPG AKGEPGDAGA KGDAGPPGPA
GPTGAPGPIG NVGAPGPKGS PGPPGATGFP GAAGRVGPPG PSGNAGPPGP PGPAGKGETG
PAGRPGEIGP PGPPGPSGEK GSPGADGPAG APGTPGPQGI GGQRGVVGIP GQRGFPGIPG
PSGEPGKQGP SGPNGERGPP GPMGPPGIAG PPGESGREGS PGAEGSPGRD GSPGPKGDRG
ETGPAGPPGA PGAPGAPGPV GPAGKSGDRG ETGPAGPAGP IGPVGARGPT GPQGPRGDKG
ETGEQGDRGF SGIQGPPGPP GSPGEQGPSG ASGPAGPRGP PGSAGAPGKD GINGIPGPIG
PPGPRTGDAG PVGPPGPPGP PGPPGPP
