CO1A1_TOXSP
ID CO1A1_TOXSP Reviewed; 982 AA.
AC C0HJP7;
DT 22-JUL-2015, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2015, sequence version 1.
DT 03-AUG-2022, entry version 15.
DE RecName: Full=Collagen alpha-1(I) chain {ECO:0000303|PubMed:25799987};
DE AltName: Full=Alpha-1 type I collagen {ECO:0000250|UniProtKB:P02452};
DE Flags: Fragments;
GN Name=COL1A1 {ECO:0000250|UniProtKB:P02452};
OS Toxodon sp.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Notoungulata; Toxodontidae; Toxodon; unclassified Toxodon.
OX NCBI_TaxID=1563122 {ECO:0000303|PubMed:25799987};
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Bone {ECO:0000303|PubMed:25799987};
RX PubMed=25799987; DOI=10.1038/nature14249;
RA Welker F., Collins M.J., Thomas J.A., Wadsley M., Brace S., Cappellini E.,
RA Turvey S.T., Reguero M., Gelfo J.N., Kramarz A., Burger J.,
RA Thomas-Oates J., Ashford D.A., Ashton P.D., Rowsell K., Porter D.M.,
RA Kessler B., Fischer R., Baessmann C., Kaspar S., Olsen J.V., Kiley P.,
RA Elliott J.A., Kelstrup C.D., Mullin V., Hofreiter M., Willerslev E.,
RA Hublin J.J., Orlando L., Barnes I., MacPhee R.D.;
RT "Ancient proteins resolve the evolutionary history of Darwin's South
RT American ungulates.";
RL Nature 522:81-84(2015).
CC -!- FUNCTION: Type I collagen is a member of group I collagen (fibrillar
CC forming collagen). {ECO:0000305}.
CC -!- SUBUNIT: Trimers of one alpha 2(I) and two alpha 1(I) chains.
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted. Secreted, extracellular space.
CC Secreted, extracellular space, extracellular matrix {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Forms the fibrils of tendon, ligaments and bones.
CC In bones, the fibrils are mineralized with calcium hydroxyapatite.
CC {ECO:0000305}.
CC -!- PTM: Prolines at the third position of the tripeptide repeating unit
CC (G-X-Y) are hydroxylated in some or all of the chains. {ECO:0000305}.
CC -!- MISCELLANEOUS: These protein fragments were extracted from fossils. The
CC tryptic peptides required multiple purification steps in order to
CC eliminate contaminants and to increase the concentration of peptidic
CC material. {ECO:0000305|PubMed:25799987}.
CC -!- SIMILARITY: Belongs to the fibrillar collagen family. {ECO:0000305}.
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DR AlphaFoldDB; C0HJP7; -.
DR PRIDE; C0HJP7; -.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR InterPro; IPR008160; Collagen.
DR Pfam; PF01391; Collagen; 11.
PE 1: Evidence at protein level;
KW Calcium; Collagen; Direct protein sequencing; Extinct organism protein;
KW Extracellular matrix; Hydroxylation; Phosphoprotein; Repeat; Secreted.
FT CHAIN 1..982
FT /note="Collagen alpha-1(I) chain"
FT /evidence="ECO:0000269|PubMed:25799987"
FT /id="PRO_0000433499"
FT REGION 1..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..36
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..243
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..381
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..701
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..982
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 81
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02454"
FT MOD_RES 586
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02454"
FT UNSURE 65
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 71
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 83
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 116
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 215
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 289
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 343
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 349
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 454
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 476
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 525
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 537
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 564
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 568
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 652
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 750
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 759
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 771
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 796
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 801
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 874
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 906
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 945
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 948
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 952
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT NON_CONS 9..10
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 281..282
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 508..509
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 702..703
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 901..902
FT /evidence="ECO:0000303|PubMed:25799987"
SQ SEQUENCE 982 AA; 87148 MW; 2D35D9E8C05B3C10 CRC64;
GPMGPSGPRG FQGPPGEPGE PGASGPMGPR GPPGPPGKNG DDGEAGKPGR PGERGPPGPQ
GARGIPGTAG IPGMKGHRGF SGIDGAKGDA GPAGPKGEPG SPGENGAPGQ MGPRGIPGER
GRPGPTGPAG ARGNDGATGA AGPPGPTGPA GPPGFPGAVG AKGEAGPQGA RGSEGPQGVR
GEPGPPGPAG AAGPAGNPGA DGQPGAKGAN GAPGIAGAPG FPGARGPSGP QGPSGPPGPK
GNSGEPGAPG SKGDAGAKGE PGPTGVQGPP GPAGEEGKRG AGEPGPTGIP GPPGERGGPG
SRGFPGADGV AGPKGPAGER GAPGPAGPKG SPGEAGRPGE AGIPGAKGIT GSPGSPGPDG
KTGPPGPAGQ DGRPGPPGPP GARGQAGVMG FPGPKGAAGE PGKAGERGVP GPPGAVGPAG
KDGEAGAQGP PGSAGPAGER GEQGPAGSPG FQGIPGPAGP PGESGKPGEQ GVPGDIGAPG
PSGARGERGF PGERGVQGPP GPAGPRGAGD AGAPGAPGSQ GAPGIQGMPG ERGAAGIPGP
KGDRGDAGPK GADGSPGKDG VRGITGPIGP PGPAGAPGDK GESGPSGPAG PTGARGAPGD
RGEPGPPGPA GFAGPPGADG QPGAKGEPGD AGAKGDAGPA GPAGPTGPPG PIGNVGAPGP
KGARGSAGPP GATGFPGAAG RVGPPGPAGN AGPPGPPGPV GKKGPRGETG PAGRPGEVGP
PGPPGPAGEK GSPGSDGPAG APGTPGPQGI AGQRGVVGIP GQRGERGFPG IPGPSGEPGK
QGPSGASGER GPPGPIGPPG IAGPPGESGR EGAPGAEGSP GRDGSPGPKG DRGEAGPAGP
PGAPGAPGAP GPVGPAGKSG DRGETGPAGP AGPIGPTGAR GPAGPQGPRG DKGETGEQGD
RGFSGIQGPP GPPGSPGEQG PAGASGPAGP RGPPGSAGAP GKDGINGIPG PIGPPGPRGR
TGPAGPRGPP GPPGAPGPPG PP
