ACL7B_MOUSE
ID ACL7B_MOUSE Reviewed; 418 AA.
AC Q9QY83; Q14AJ4; Q9JMI6;
DT 27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Actin-like protein 7B;
DE AltName: Full=Actin-like-7-beta;
DE AltName: Full=Testis-specific actin-1;
DE Short=T-actin-1;
GN Name=Actl7b; Synonyms=Tact1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CD-1; TISSUE=Testis;
RX PubMed=10373328; DOI=10.1006/geno.1999.5848;
RA Chadwick B.P., Mull J., Helbling L.A., Gill S., Leyne M., Robbins C.M.,
RA Pinkett H.W., Makalowska I., Maayan C., Blumenfeld A., Axelrod F.B.,
RA Brownstein M., Gusella J.F., Slaugenhaupt S.A.;
RT "Cloning, mapping, and expression of two novel actin genes, actin-like-7A
RT (ACTL7A) and actin-like-7B (ACTL7B), from the familial dysautonomia
RT candidate region on 9q31.";
RL Genomics 58:302-309(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RA Tanaka H., Iguchi N., Carvalho C.E., Nozaki M., Nishimune Y.;
RT "Testis specific actin.";
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv; TISSUE=Liver;
RX PubMed=12704725; DOI=10.1002/mrd.10276;
RA Hisano M., Yamada S., Tanaka H., Nishimune Y., Nozaki M.;
RT "Genomic structure and promoter activity of the testis haploid germ cell-
RT specific intronless genes, Tact1 and Tact2.";
RL Mol. Reprod. Dev. 65:148-156(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Testis specific.
CC -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR EMBL; AF113520; AAF18299.1; -; mRNA.
DR EMBL; AB023062; BAA90821.1; -; mRNA.
DR EMBL; AB079643; BAC07296.1; -; Genomic_DNA.
DR EMBL; AL807762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466565; EDL02259.1; -; Genomic_DNA.
DR EMBL; BC116815; AAI16816.1; -; mRNA.
DR EMBL; BC116817; AAI16818.1; -; mRNA.
DR CCDS; CCDS18196.1; -.
DR RefSeq; NP_079547.2; NM_025271.2.
DR AlphaFoldDB; Q9QY83; -.
DR SMR; Q9QY83; -.
DR STRING; 10090.ENSMUSP00000092693; -.
DR PhosphoSitePlus; Q9QY83; -.
DR REPRODUCTION-2DPAGE; Q9QY83; -.
DR PaxDb; Q9QY83; -.
DR PeptideAtlas; Q9QY83; -.
DR PRIDE; Q9QY83; -.
DR ProteomicsDB; 285979; -.
DR Antibodypedia; 14908; 278 antibodies from 29 providers.
DR DNASU; 11471; -.
DR Ensembl; ENSMUST00000095080; ENSMUSP00000092693; ENSMUSG00000070980.
DR GeneID; 11471; -.
DR KEGG; mmu:11471; -.
DR UCSC; uc008sxn.1; mouse.
DR CTD; 10880; -.
DR MGI; MGI:1343053; Actl7b.
DR VEuPathDB; HostDB:ENSMUSG00000070980; -.
DR eggNOG; KOG0676; Eukaryota.
DR GeneTree; ENSGT00940000162582; -.
DR HOGENOM; CLU_027965_0_2_1; -.
DR InParanoid; Q9QY83; -.
DR OMA; WDCVQNI; -.
DR OrthoDB; 964605at2759; -.
DR PhylomeDB; Q9QY83; -.
DR TreeFam; TF354237; -.
DR BioGRID-ORCS; 11471; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q9QY83; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9QY83; protein.
DR Bgee; ENSMUSG00000070980; Expressed in seminiferous tubule of testis and 23 other tissues.
DR Genevisible; Q9QY83; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005869; C:dynactin complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR027680; ACTL7B.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR PANTHER; PTHR11937:SF59; PTHR11937:SF59; 1.
DR Pfam; PF00022; Actin; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT CHAIN 1..418
FT /note="Actin-like protein 7B"
FT /id="PRO_0000089141"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 8
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q4QR76"
FT CONFLICT 85..86
FT /note="SA -> RP (in Ref. 1; AAF18299)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 418 AA; 45565 MW; 81ED555E1D2B5088 CRC64;
MATKNSPSPK PMGTAQGDPG EAGTLPAPEA AGIRDTGSTQ LKTKPKKIRK IKALVIDLGS
QYCKCGYAGE PRPTYFISST VGKRSAEMAA DAGDNFKETY VGHELLNMEA SLKLVNPLKH
GVVVDWDCIQ NIWEYIFHTA MKIMPEEHAV LVSDPPLSPT SNREKYAELL FETFGIPAMH
VTSQALLSIY SYGKTSGLVV ESGHGVSHVV PISEGDLLPG LPSRVDYAGC DLTNYLMQLL
NEAGHKFSDD HLHIIEHIKK KCCYAALLPE EEMSLGLDEL HVDYELPDGK IITIGQERFR
CSEMLFKPSL VGCTQPGLPE LTATCLARCQ GTGFKEEMAA NVLLCGGCTM LDGFPERFQR
ELSLLCPGDS PTVAAAPERK TSVWTGGSIL ASLQAFQQLW VSKEEFEERG CAAIYSKC
