CO1A2_CYCDI
ID CO1A2_CYCDI Reviewed; 838 AA.
AC C0HJP2;
DT 22-JUL-2015, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2015, sequence version 1.
DT 25-MAY-2022, entry version 11.
DE RecName: Full=Collagen alpha-2(I) chain {ECO:0000303|PubMed:25799987};
DE AltName: Full=Alpha-2 type I collagen {ECO:0000250|UniProtKB:P08123};
DE Flags: Fragments;
GN Name=COL1A2 {ECO:0000250|UniProtKB:P08123};
OS Cyclopes didactylus (Silky anteater) (Myrmecophaga didactyla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Xenarthra; Pilosa; Vermilingua; Cyclopedidae; Cyclopes.
OX NCBI_TaxID=84074 {ECO:0000303|PubMed:25799987};
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Bone {ECO:0000303|PubMed:25799987};
RX PubMed=25799987; DOI=10.1038/nature14249;
RA Welker F., Collins M.J., Thomas J.A., Wadsley M., Brace S., Cappellini E.,
RA Turvey S.T., Reguero M., Gelfo J.N., Kramarz A., Burger J.,
RA Thomas-Oates J., Ashford D.A., Ashton P.D., Rowsell K., Porter D.M.,
RA Kessler B., Fischer R., Baessmann C., Kaspar S., Olsen J.V., Kiley P.,
RA Elliott J.A., Kelstrup C.D., Mullin V., Hofreiter M., Willerslev E.,
RA Hublin J.J., Orlando L., Barnes I., MacPhee R.D.;
RT "Ancient proteins resolve the evolutionary history of Darwin's South
RT American ungulates.";
RL Nature 522:81-84(2015).
CC -!- FUNCTION: Type I collagen is a member of group I collagen (fibrillar
CC forming collagen). {ECO:0000305}.
CC -!- SUBUNIT: Trimers of one alpha 2(I) and two alpha 1(I) chains.
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted. Secreted, extracellular space.
CC Secreted, extracellular space, extracellular matrix {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Forms the fibrils of tendon, ligaments and bones.
CC In bones, the fibrils are mineralized with calcium hydroxyapatite.
CC {ECO:0000305}.
CC -!- PTM: Prolines at the third position of the tripeptide repeating unit
CC (G-X-Y) are hydroxylated in some or all of the chains. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the fibrillar collagen family. {ECO:0000305}.
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DR AlphaFoldDB; C0HJP2; -.
DR PRIDE; C0HJP2; -.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR InterPro; IPR008160; Collagen.
DR Pfam; PF01391; Collagen; 3.
PE 1: Evidence at protein level;
KW Calcium; Collagen; Direct protein sequencing; Extracellular matrix;
KW Hydroxylation; Repeat; Secreted.
FT CHAIN 1..838
FT /note="Collagen alpha-2(I) chain"
FT /evidence="ECO:0000269|PubMed:25799987"
FT /id="PRO_0000433500"
FT REGION 1..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..130
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT UNSURE 5
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 68
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 71
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 86
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 117
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 135
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 157
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 166
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 181
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 229
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 235
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 274
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 286
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 289
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 305
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 328
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 370
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 388
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 394
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 419
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 454
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 475
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 566
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 610
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 655
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 656
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 661
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 662
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 664
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 670
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 683
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 685
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 727
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 779
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 785
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 788
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 791
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT UNSURE 836
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:25799987"
FT NON_CONS 9..10
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 63..64
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 81..82
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 151..152
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 161..162
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 191..192
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 231..232
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 278..279
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 299..300
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 554..555
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 622..623
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 647..648
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 668..669
FT /evidence="ECO:0000303|PubMed:25799987"
FT NON_CONS 782..783
FT /evidence="ECO:0000303|PubMed:25799987"
SQ SEQUENCE 838 AA; 74962 MW; 17AEFCFFDB450AFC CRC64;
GPMGIMGPRG FQGPAGEPGE PGQTGPAGAR GPAGPPGKAG EDGHPGKPGR PGERGVVGPQ
GARGHNGIDG IKGQAGAPGV KGARGIPGER GRVGAPGPAG SRGSDGSVGP VGPAGPIGSA
GPPGFPGAPG PKGEIGPVGN TGPAGPAGPR GKGAAGIPGV AGPRGIPGPV GASGATGARG
IVGEPGPAGS KGEPGSAGPQ GPPGPSGEEG KRGPNGESGS SGPTGPPGIR GSRGIPGADG
RAGVMGPAGA RGASGPTGVR GPSGDTGRPG EPGIMGPRGK EGPVGIPGID GRVGPAGPAG
EAGNIGFPGP KGPTGDPGKV GEKGHAGIAG NRGAPGPDGN NGAQGPPGPQ GVQGGKGEQG
PAGPPGFQGI PGPAGTTGEV GKPGERGITG EFGIPGPAGP RGERGPPGES GAAGPSGPIG
SRGPSGPPGP DGNKGEPGVV GAPGTAGPAG SGGIPGERGA AGMPGGKGEK GETGIRGEVG
TTGRDGARGA PGAVGAPGPA GATGDRGEAG AAGPAGPAGP RGTPGERGEV GPAGPNGFAG
PAGAAGQPGA KGERGENGVV GPTGPIGSAG PAGPDGTPGP AGSRGDGGPP GVTGFPGAAG
RTGPPGPSGI TGPPGPPGAA GKRGDQGPVG RSGETGAGGP PGFTGEKGTA GPQGIIGAPG
IIGIPGSRGI PGVSGSVGEP GPIGISGPPG ARGPSGGVGN PGVNGAPGEA GRDGNPGNDG
PPGRDGIPGH KGERGYAGNP GPVGAAGAPG PHGSVGPAGK HGNRGEPGPV GSVGPVGAIG
PRNGIQGIPG IAGQHGDQGA PGSVGPAGPR GPAGPGGPPG KDGRTGHPGT VGPAGIRS
