ID   CO2A1_MAMAE             Reviewed;         669 AA.
AC   P85153;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Collagen alpha-1(II) chain;
DE   AltName: Full=Alpha-1 type II collagen;
DE   Flags: Fragment;
OS   Mammut americanum (American mastodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Mammut.
OX   NCBI_TaxID=39053;
RN   [1]
RP   PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, AND HYDROXYLATION AT
RP   PRO-3; PRO-12; PRO-336; PRO-345; PRO-414; PRO-420; PRO-426 AND PRO-648.
RC   TISSUE=Bone;
RA   Asara J.M.;
RL   Submitted (SEP-2007) to UniProtKB.
CC   -!- FUNCTION: Type II collagen is specific for cartilaginous tissues. It is
CC       essential for the normal embryonic development of the skeleton, for
CC       linear growth and for the ability of cartilage to resist compressive
CC       forces. {ECO:0000305}.
CC   -!- SUBUNIT: Homotrimers of alpha 1(II) chains. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250}.
CC   -!- PTM: Contains mostly 4-hydroxyproline. Prolines at the third position
CC       of the tripeptide repeating unit (G-X-P) are 4-hydroxylated in some or
CC       all of the chains. {ECO:0000269|Ref.1}.
CC   -!- PTM: Contains 3-hydroxyproline at a few sites. This modification occurs
CC       on the first proline residue in the sequence motif Gly-Pro-Hyp, where
CC       Hyp is 4-hydroxyproline. {ECO:0000250|UniProtKB:P05539}.
CC   -!- MISCELLANEOUS: These protein fragments were extracted from 160,000 to
CC       600,000 year old bones. The tryptic peptides required multiple
CC       purification steps in order to eliminate contaminants and to increase
CC       the concentration of peptidic material.
CC   -!- SIMILARITY: Belongs to the fibrillar collagen family. {ECO:0000255}.
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DR   PRIDE; P85153; -.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Collagen; Direct protein sequencing; Extinct organism protein;
KW   Extracellular matrix; Hydroxylation; Repeat; Secreted.
FT   CHAIN           <1..>669
FT                   /note="Collagen alpha-1(II) chain"
FT                   /id="PRO_0000291374"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          314..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          636..669
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         3
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|Ref.1"
FT   MOD_RES         12
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|Ref.1"
FT   MOD_RES         336
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|Ref.1"
FT   MOD_RES         345
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|Ref.1"
FT   MOD_RES         413
FT                   /note="3-hydroxyproline"
FT                   /evidence="ECO:0000250|UniProtKB:P05539"
FT   MOD_RES         414
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|Ref.1"
FT   MOD_RES         420
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|Ref.1"
FT   MOD_RES         426
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|Ref.1"
FT   MOD_RES         648
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|Ref.1"
FT   MOD_RES         650
FT                   /note="3-hydroxyproline"
FT                   /evidence="ECO:0000250|UniProtKB:P05539"
FT   UNSURE          339
FT                   /note="A or S"
FT   UNSURE          342
FT                   /note="A or S"
FT   UNSURE          654
FT                   /note="S or A"
FT   NON_TER         1
FT   NON_TER         669
SQ   SEQUENCE   669 AA;  72100 MW;  8875FA5F7ACC4CE5 CRC64;
     GEPGGVGPIG PPGERGAPGN RXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXGAPGER GETGPPGPAG FAGPPGADGQ PGAKXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX VGPPGANGNP
     GPAGPPGPAG KXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXG FTGLQGLPGP PGTSGDQGAS
     GPSGPAGPR