CO2FA_CONBE
ID CO2FA_CONBE Reviewed; 87 AA.
AC B0KZ78;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 1.
DT 25-MAY-2022, entry version 32.
DE RecName: Full=Conotoxin Bt15a;
DE Flags: Precursor;
OS Conus betulinus (Beech cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Dendroconus.
OX NCBI_TaxID=89764;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RA Jiang X., Pi C., Liu Y.;
RT "A novel class of conotoxin cDNAs with a distinctive cysteine
RT arrangement.";
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The cysteine framework is XV (C-C-CC-C-C-C-C).
CC -!- PTM: Contains 4 disulfide bonds. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the conotoxin O2 superfamily. {ECO:0000305}.
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DR EMBL; DQ512965; ABG01719.1; -; mRNA.
DR AlphaFoldDB; B0KZ78; -.
DR ConoServer; 2758; Bt15a precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Pyrrolidone carboxylic acid; Secreted; Signal; Toxin.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..49
FT /evidence="ECO:0000250"
FT /id="PRO_0000392180"
FT PEPTIDE 50..87
FT /note="Conotoxin Bt15a"
FT /id="PRO_0000392181"
FT MOD_RES 50
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
SQ SEQUENCE 87 AA; 9746 MW; 3CB53132A25593A0 CRC64;
MEKLTILVLV ATVLLAIQVL VQSDGEKPLK RRVKQYAAKR LSALMRGPRQ CTPRNQRCEG
DAECCPNLVC KCFTRPDCQS GYKCDTS