ID   CO2FA_CONEM             Reviewed;          86 AA.
AC   B0KZ79;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Conotoxin Ec15a;
DE   Flags: Precursor;
OS   Conus emaciatus (False virgin cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Virgiconus.
OX   NCBI_TaxID=89442;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RA   Jiang X., Pi C., Liu Y.;
RT   "A novel class of conotoxin cDNAs with a distinctive cysteine
RT   arrangement.";
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is XV (C-C-CC-C-C-C-C).
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the conotoxin O2 superfamily. {ECO:0000305}.
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DR   EMBL; DQ512966; ABG01720.1; -; mRNA.
DR   AlphaFoldDB; B0KZ79; -.
DR   SMR; B0KZ79; -.
DR   ConoServer; 2759; Ec15a precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Pyrrolidone carboxylic acid; Secreted; Signal; Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..49
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000392186"
FT   PEPTIDE         50..86
FT                   /note="Conotoxin Ec15a"
FT                   /id="PRO_0000392187"
FT   MOD_RES         50
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   86 AA;  9501 MW;  6997DE07572A610F CRC64;
     MEKLTILILV ATVLLAIQVL GQGEGEKPPK EWVQQYAAKR LWALMKGPRQ CTPKDAPCDD
     NNQCCSGLEC KCFNMPDCQS GSTCRV