CO2FA_CONLT
ID CO2FA_CONLT Reviewed; 86 AA.
AC Q2I2Q6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 30.
DE RecName: Full=Conotoxin Lt15a;
DE AltName: Full=Lt15.1;
DE Flags: Precursor;
OS Conus litteratus (Lettered cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Elisaconus.
OX NCBI_TaxID=89445;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=16908117; DOI=10.1016/j.ygeno.2006.06.014;
RA Pi C., Liu J., Peng C., Liu Y., Jiang X., Zhao Y., Tang S., Wang L.,
RA Dong M., Chen S., Xu A.;
RT "Diversity and evolution of conotoxins based on gene expression profiling
RT of Conus litteratus.";
RL Genomics 88:809-819(2006).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The cysteine framework is XV (C-C-CC-C-C-C-C).
CC -!- PTM: Contains 4 disulfide bonds. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the conotoxin O2 superfamily. {ECO:0000305}.
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DR EMBL; DQ345376; ABC74984.1; -; mRNA.
DR AlphaFoldDB; Q2I2Q6; -.
DR PRIDE; Q2I2Q6; -.
DR ConoServer; 1162; LtXVA precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Secreted; Signal; Toxin.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..49
FT /evidence="ECO:0000250"
FT /id="PRO_0000315504"
FT PEPTIDE 50..86
FT /note="Conotoxin Lt15a"
FT /id="PRO_0000315505"
SQ SEQUENCE 86 AA; 9697 MW; E6D954F1C5223D7E CRC64;
MEKLTILILV ATVLLAIQVL VQSDGENPVK GRVKHYAAKR FSALFRGPRE CTTKHRRCEK
DEECCPNLEC KCLTSPDCQS GYKCKP