ID   CO2FA_CONMI             Reviewed;          85 AA.
AC   C8CK74;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Conotoxin Ml15a;
DE   Flags: Precursor;
OS   Conus miles (Soldier cone) (Mile cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Rhizoconus.
OX   NCBI_TaxID=69564;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RA   Wang L., Jiang X., Wu Y., Zhou M., Xu A.;
RT   "A novel class of conotoxin cDNAs with a distinctive cysteine
RT   arrangement.";
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is XV (C-C-CC-C-C-C-C).
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the conotoxin O2 superfamily. {ECO:0000305}.
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DR   EMBL; GQ414737; ACV07667.1; -; mRNA.
DR   AlphaFoldDB; C8CK74; -.
DR   SMR; C8CK74; -.
DR   ConoServer; 3870; Mi15a precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Pyrrolidone carboxylic acid; Secreted; Signal; Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..49
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000392190"
FT   PEPTIDE         50..85
FT                   /note="Conotoxin Ml15a"
FT                   /id="PRO_0000392191"
FT   MOD_RES         50
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   85 AA;  9546 MW;  869F905D6111C39C CRC64;
     MEKLTVLILV ATVLLTIQVL GQSDRDKHLK RRPKQYATKR LSARMRGHRQ CTGAGYECEE
     TPECCPNLTC KCSGSPLCTR YSCQA