CO2FB_CONMI
ID CO2FB_CONMI Reviewed; 85 AA.
AC C8CK75;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 13-OCT-2009, sequence version 1.
DT 25-MAY-2022, entry version 24.
DE RecName: Full=Conotoxin Ml15b;
DE Flags: Precursor;
OS Conus miles (Soldier cone) (Mile cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Rhizoconus.
OX NCBI_TaxID=69564;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RA Wang L., Jiang X., Wu Y., Zhou M., Xu A.;
RT "A novel class of conotoxin cDNAs with a distinctive cysteine
RT arrangement.";
RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The cysteine framework is XV (C-C-CC-C-C-C-C).
CC -!- PTM: Contains 4 disulfide bonds. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the conotoxin O2 superfamily. {ECO:0000305}.
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DR EMBL; GQ414738; ACV07668.1; -; mRNA.
DR AlphaFoldDB; C8CK75; -.
DR SMR; C8CK75; -.
DR ConoServer; 3869; Mi15b precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Pyrrolidone carboxylic acid; Secreted; Signal; Toxin.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..49
FT /evidence="ECO:0000250"
FT /id="PRO_0000392192"
FT PEPTIDE 50..85
FT /note="Conotoxin Ml15b"
FT /id="PRO_0000392193"
FT MOD_RES 50
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
SQ SEQUENCE 85 AA; 9582 MW; E9D8D79DCC8AD395 CRC64;
MEKLTVLILV AIVLLTIQVL GQSDRDKHPK RRPRQYATKR LSALMKGHRQ CTGAGFECEE
TPECCPNLTC KCSGSPLCTR YRCKT