ID   COA1_SCHPO              Reviewed;         249 AA.
AC   O14320;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Cytochrome c oxidase assembly factor 1;
GN   Name=coa1; ORFNames=SPBC16E9.03c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Required for efficient assembly of cytochrome c oxidase in
CC       the mitochondrial inner membrane. Involved in a step coupling MSS51-
CC       dependent cotranslational insertion of COX1 to the addition of its heme
CC       A and copper B cofactors (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COA1 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAB16896.1; -; Genomic_DNA.
DR   PIR; T39578; T39578.
DR   RefSeq; NP_595785.1; NM_001021686.2.
DR   AlphaFoldDB; O14320; -.
DR   SMR; O14320; -.
DR   BioGRID; 276465; 1.
DR   STRING; 4896.SPBC16E9.03c.1; -.
DR   MaxQB; O14320; -.
DR   PaxDb; O14320; -.
DR   EnsemblFungi; SPBC16E9.03c.1; SPBC16E9.03c.1:pep; SPBC16E9.03c.
DR   GeneID; 2539921; -.
DR   KEGG; spo:SPBC16E9.03c; -.
DR   PomBase; SPBC16E9.03c; coa1.
DR   VEuPathDB; FungiDB:SPBC16E9.03c; -.
DR   HOGENOM; CLU_1116302_0_0_1; -.
DR   InParanoid; O14320; -.
DR   PRO; PR:O14320; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISO:PomBase.
DR   GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; ISO:PomBase.
DR   InterPro; IPR014807; Coa1.
DR   InterPro; IPR042432; Coa1_fungi.
DR   PANTHER; PTHR28523; PTHR28523; 1.
DR   Pfam; PF08695; Coa1; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..249
FT                   /note="Cytochrome c oxidase assembly factor 1"
FT                   /id="PRO_0000373998"
FT   TOPO_DOM        1..123
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        145..249
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   249 AA;  28236 MW;  3A44AF48A0F44151 CRC64;
     MISSKSLDYT RFLPFFAALV RGHCLTVKSP THNCGSGVKT IMDKSSIFLK NRYPISINRF
     VQQRKTFCGA SVCLHKVLVQ RQFGFEEKSH GLKYKKLFRR NIGTSEKKNR LPDLLELSSS
     PRRLPILFAA FCLLWGTCAV LAIQYGKQNS NVTQVVMYRV QHSKEAQDLL GSNIDFKYPF
     PWVPGKLHKR QGFIDINFEV SGSLASGTVH YQSQRFGPIA HWVELDCTLT SNGKTIKIPT
     GVSKDTQWT