ID   COA2_YEAST              Reviewed;          68 AA.
AC   Q3E823; D6W3H9;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Cytochrome c oxidase assembly factor 2;
GN   Name=COA2; OrderedLocusNames=YPL189C-A;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169875;
RA   Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA   Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA   Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA   Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA   DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA   Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA   Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA   Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA   Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA   Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA   Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA   Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA   Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA   Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA   Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA   Vo D.H., Hani J.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL   Nature 387:103-105(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   GENOME REANNOTATION.
RX   PubMed=12844361; DOI=10.1186/gb-2003-4-7-r45;
RA   Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A.,
RA   Gates K., Gaffney T.D., Philippsen P.;
RT   "Reinvestigation of the Saccharomyces cerevisiae genome annotation by
RT   comparison to the genome of a related fungus: Ashbya gossypii.";
RL   Genome Biol. 4:R45.1-R45.13(2003).
RN   [4]
RP   FUNCTION, INTERACTION WITH SHY1, AND SUBCELLULAR LOCATION.
RX   PubMed=18541668; DOI=10.1128/mcb.00057-08;
RA   Pierrel F., Khalimonchuk O., Cobine P.A., Bestwick M.L., Winge D.R.;
RT   "Coa2 is an assembly factor for yeast cytochrome C oxidase biogenesis that
RT   facilitates the maturation of cox1.";
RL   Mol. Cell. Biol. 28:4927-4939(2008).
CC   -!- FUNCTION: Required for efficient assembly of cytochrome c oxidase in
CC       the mitochondrial inner membrane. Seems to be involved in the SHY1-
CC       mediated step of cytochrome c oxidase maturation. May aid in
CC       stabilizing an early COX1 intermediate containing the nuclear subunits
CC       COX5A and COX6. {ECO:0000269|PubMed:18541668}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000269|PubMed:18541668}; Peripheral membrane protein
CC       {ECO:0000269|PubMed:18541668}; Matrix side
CC       {ECO:0000269|PubMed:18541668}. Note=Mitochondrial matrix soluble
CC       protein partially associated with the inner membrane.
CC   -!- SIMILARITY: Belongs to the COA2 family. {ECO:0000305}.
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DR   EMBL; Z73545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK006949; DAA11245.1; -; Genomic_DNA.
DR   RefSeq; NP_878179.1; NM_001184537.1.
DR   AlphaFoldDB; Q3E823; -.
DR   BioGRID; 37060; 44.
DR   STRING; 4932.YPL189C-A; -.
DR   PaxDb; Q3E823; -.
DR   EnsemblFungi; YPL189C-A_mRNA; YPL189C-A; YPL189C-A.
DR   GeneID; 1466518; -.
DR   KEGG; sce:YPL189C-A; -.
DR   SGD; S000028527; COA2.
DR   VEuPathDB; FungiDB:YPL189C-A; -.
DR   eggNOG; ENOG502SBZ5; Eukaryota.
DR   HOGENOM; CLU_196962_0_0_1; -.
DR   InParanoid; Q3E823; -.
DR   OMA; MNNLYLT; -.
DR   BioCyc; YEAST:G3O-34363-MON; -.
DR   PRO; PR:Q3E823; -.
DR   Proteomes; UP000002311; Chromosome XVI.
DR   RNAct; Q3E823; protein.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005759; C:mitochondrial matrix; IDA:SGD.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IMP:SGD.
DR   InterPro; IPR031459; Coa2.
DR   Pfam; PF17051; COA2; 1.
PE   1: Evidence at protein level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome.
FT   CHAIN           1..68
FT                   /note="Cytochrome c oxidase assembly factor 2"
FT                   /id="PRO_0000238657"
SQ   SEQUENCE   68 AA;  7533 MW;  4ADDB91D3ABC012D CRC64;
     MRAVTRNKIV NNLYFSTFLI AFASVAIGSV LPCPAHSVDS DSPAVQQHKL QLAHEQELKR
     KDALSKKI