ID   COA3_BOVIN              Reviewed;         106 AA.
AC   Q3T0E3;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Cytochrome c oxidase assembly factor 3 homolog, mitochondrial;
DE   AltName: Full=Coiled-coil domain-containing protein 56;
GN   Name=COA3; Synonyms=CCDC56;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Core component of the MITRAC (mitochondrial translation
CC       regulation assembly intermediate of cytochrome c oxidase complex)
CC       complex, that regulates cytochrome c oxidase assembly. MITRAC complexes
CC       regulate both translation of mitochondrial encoded components and
CC       assembly of nuclear-encoded components imported in mitochondrion.
CC       Required for efficient translation of MT-CO1 and mitochondrial
CC       respiratory chain complex IV assembly. {ECO:0000250|UniProtKB:Q9Y2R0}.
CC   -!- SUBUNIT: Along with COX14, core component of the MITRAC (mitochondrial
CC       translation regulation assembly intermediate of cytochrome c oxidase
CC       complex) complex. Interacts with MT-CO1/COX1, SMIM20, SURF1 and TIMM21.
CC       {ECO:0000250|UniProtKB:Q9Y2R0}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COA3 family. {ECO:0000305}.
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DR   EMBL; BC102431; AAI02432.1; -; mRNA.
DR   RefSeq; NP_001029855.1; NM_001034683.1.
DR   AlphaFoldDB; Q3T0E3; -.
DR   SMR; Q3T0E3; -.
DR   STRING; 9913.ENSBTAP00000026525; -.
DR   PaxDb; Q3T0E3; -.
DR   PRIDE; Q3T0E3; -.
DR   Ensembl; ENSBTAT00000026525; ENSBTAP00000026525; ENSBTAG00000019911.
DR   GeneID; 539832; -.
DR   KEGG; bta:539832; -.
DR   CTD; 28958; -.
DR   VEuPathDB; HostDB:ENSBTAG00000019911; -.
DR   VGNC; VGNC:27543; COA3.
DR   eggNOG; KOG4782; Eukaryota.
DR   GeneTree; ENSGT00390000016262; -.
DR   HOGENOM; CLU_167761_0_1_1; -.
DR   InParanoid; Q3T0E3; -.
DR   OMA; MHFIRQV; -.
DR   OrthoDB; 1515241at2759; -.
DR   TreeFam; TF314703; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000019911; Expressed in pons and 105 other tissues.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; ISS:UniProtKB.
DR   GO; GO:0070131; P:positive regulation of mitochondrial translation; ISS:UniProtKB.
DR   InterPro; IPR041752; Coa3.
DR   InterPro; IPR018628; Coa3_cc.
DR   PANTHER; PTHR15642; PTHR15642; 1.
DR   Pfam; PF09813; Coiled-coil_56; 1.
PE   3: Inferred from homology;
KW   Acetylation; Coiled coil; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y2R0"
FT   CHAIN           2..106
FT                   /note="Cytochrome c oxidase assembly factor 3 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000239437"
FT   TOPO_DOM        2..57
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..106
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          78..104
FT                   /evidence="ECO:0000255"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y2R0"
SQ   SEQUENCE   106 AA;  11707 MW;  66F1C6E863FC5400 CRC64;
     MATPGPGDPV DAKSGKAPLA QRIDPTREKL TPAQLQFMRQ AQLAQWQKTL PQRRTRNIVT
     GLGIGALVLA IYGYTFYSVS QERFLDELED EAKAARARAL ERASGH